In 1989 Michael Bishop and Harold Varmus were awarded the Nobel Prize for their discovery that normal genes under certain conditions can cause cancer. In this book, Bishop tells us how he and Varmus made their momentous discovery. More than a lively account of the making of a brilliant scientist, How to Win the Nobel Prize is also a broader narrative combining two major and intertwined strands of medical history: the long and ongoing struggles to control infectious diseases and to find and attack the causes of cancer.

Alongside his own story, that of a youthful humanist evolving into an ambivalent medical student, an accidental microbiologist, and finally a world-class researcher, Bishop gives us a fast-paced and engrossing tale of the microbe hunters. It is a narrative enlivened by vivid anecdotes about our deadliest microbial enemies--the Black Death, cholera, syphilis, tuberculosis, malaria, smallpox, HIV--and by biographical sketches of the scientists who led the fight against these scourges.

Bishop then provides an introduction for nonscientists to the molecular underpinnings of cancer and concludes with an analysis of many of today's most important science-related controversies--ranging from stem cell research to the attack on evolution to scientific misconduct. How to Win the Nobel Prize affords us the pleasure of hearing about science from a brilliant practitioner who is a humanist at heart. Bishop's perspective will be valued by anyone interested in biomedical research and in the past, present, and future of the battle against cancer.

Four years in the making, this entirely revised edition of a classic text provides a lucid and erudite review of the state of psychiatry today. Since the publication of the last edition in 1988, remarkable advances have been made in laboratory and clinical psychiatric research; the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) has been published; managed care has radically altered the provision of all medical care; and the profession of psychiatry has come to a sophisticated new understanding of the interplay between psychiatric knowledge and issues in the larger society.

All these changes are reflected in the new text. Of particular interest are the masterful and lucid reviews of current knowledge in the neurobiology of mental disorders, in the section on brain and behavior. The section on psychopathology clarifies newly emerging diagnostic categories and offers new insight into addictions, anxiety disorders, and disorders of cognition.

Like its predecessors, The Harvard Guide To Psychiatry focuses throughout on the relationship between the physician and the patient. Its unspoken motto is that the art of psychiatry is as important as the science. For this recognition of what is relevant clinically as well as technically, this book will be an essential reference and support for both the new and the experienced psychiatrist.

This new edition includes up-to-date discussions of:DSM-IVManaged careImprovements in neuroimagingThe increased use of psychoactive drugsRecent advances in molecular biologyResearch on the biology of schizophrenia, depression, anxiety, and addictive disorders

Over the course of several centuries, Western masculinity has successfully established itself as the voice of reason, knowledge, and sanity—the basis for patriarchal rule—in the face of massive testimony to the contrary. Hysterical Men boldly challenges this triumphant vision of the stable and secure male by examining the central role played by modern science and medicine in constructing and sustaining it.

Mark Micale reveals the hidden side of this vision, that is, the innumerable cases of disturbed and deranged men who passed under the eyes of male medical and scientific elites from the seventeenth century onward. Since ancient times, physicians and philosophers had closely observed and extravagantly theorized female weakness, emotionality, and madness. What these male experts failed to see—or saw but did not acknowledge—was masculine nervous and mental illness among all classes and in diverse guises. While cultural and literary intellectuals pioneered new languages of male emotional distress, European science was invested in cultivating and protecting the image of male, middle-class detachment, objectivity, and rationality despite rampant counter-evidence in the clinic, in the laboratory, and on battlefields.

The reasons for suppressing male neurosis from the official discourses of science and medicine as well as from popular view range from the personal and psychological to the professional and the political. They make for a history full of profound silences, omissions, and amnesias. Now, however, under the greatly altered circumstances of today’s gender revolution, Micale’s work allows this story to be heard.

The phenomenon of voluntary self-starvation—whether by political hunger strikers or lone anorexics—is a puzzle of engrossing power, suggesting a message more resonant and radical than any uttered aloud. In this fascinating phenomenology, Maud Ellmann teases out this message, its genesis, expression, and significance. How, she asks, has the act of eating become the metaphor for compliance, starvation the language of protest? How does the rejection of food become the rejection of intolerable social constraints—or of actual imprisonment? What is achieved at the culmination of such a protest—at the moment of death? Ellmann brilliantly unravels the answers; they lie, she shows, in the inverse relationship between bodily hunger and verbal expression, especially the written word.

Ellmann explores Yeats's idea of hunger as the food of poetry, Dickinson's belief that by abjuring food one could subsist as a god, and the dramatic messages of our century of starvers from Mahatma Ghandi to Jane Fonda. Central to her discussion is a striking comparison between the Irish Hunger Strike of 1981 and the plot of Richardson's Clarissa, in which a young woman starves to death in penance for—or, perhaps, revenge against—her rape. Both cases exhibit an extreme abundance of written words in the face of diminishing flesh.

The Hunger Artists plumbs this vampirical feeding of words on flesh, revealing strange and undeniable affinities between the labor of starvation and the birth of letters, diaries, poems, books. Ellmann works in the spirit of Kafka, who, emaciating his prose, slimmed the weighty nineteenth-century novel into compelling short tales; her prose is crisp, her message clear. She takes the bodily metaphors to their literal conclusion, to the death beds of Clarissa Harlowe and Bobby Sands, and thereby allows those bodies and those metaphors to speak to us anew.

Dr. Kaplan, winner of $100,000 Kettering Prize for cancer research, has now updated and enlarged his authoritative reference, once again drawing heavily upon the uniquely comprehensive and coherent Stanford data garnered over a twenty-year period. This edition incorporates discussion of the newer radionuclides, computed tomography and ultrasound, as well as such recent developments as the transmissibility controversy.

Major sections have been added on cell culture, surface marker characterization, and cytogenetics. The material on cell-mediated immunity has been doubled, and an entirely new chapter has been included on chemotherapy, offering an analysis of evidence bearing on the selection of optimal treatment.

Punctuated with remarkable case studies, this book explores extraordinary encounters between hermaphrodites--people born with "ambiguous" sexual anatomy--and the medical and scientific professionals who grappled with them. Alice Dreger focuses on events in France and Britain in the late nineteenth century, a moment of great tension for questions of sex roles. While feminists, homosexuals, and anthropological explorers openly questioned the natures and purposes of the two sexes, anatomical hermaphrodites suggested a deeper question: just how many human sexes are there? Ultimately hermaphrodites led doctors and scientists to another surprisingly difficult question: what is sex, really?

Hermaphrodites and the Medical Invention of Sex takes us inside the doctors' chambers to see how and why medical and scientific men constructed sex, gender, and sexuality as they did, and especially how the material conformation of hermaphroditic bodies--when combined with social exigencies--forced peculiar constructions. Throughout the book Dreger indicates how this history can help us to understand present-day conceptualizations of sex, gender, and sexuality. This leads to an epilogue, where the author discusses and questions the protocols employed today in the treatment of intersexuals (people born hermaphroditic). Given the history she has recounted, should these protocols be reconsidered and revised?

A meticulously researched account of a fascinating problem in the history of medicine, this book will compel the attention of historians, physicians, medical ethicists, intersexuals themselves, and anyone interested in the meanings and foundations of sexual identity.

From the health risks of sexual activity to those of pregnancy, abortion, and childbirth, reproduction constitutes enormous risks to a woman’s health. Ill-health conditions related to sex and reproduction account for 25 percent of the global disease burden in adult women. In sub-Saharan Africa, they account for over 40 percent. The catastrophic effects of reproductive ill-health, however, are not limited to women; for infants and adult men, they inflict 25 percent and 1 percent respectively of the global burden.

This volume offers comprehensive data and detailed discussions of the epidemiologies of three sexually transmitted diseases, HIV, and five specific maternal conditions, as well as those of congenital anomalies and perinatal conditions. Projections of the HIV epidemic are provided: by 2020 HIV is projected to double to 2.5 percent of the global disease burden.

Health Dimensions of Sex and Reproduction will serve as a comprehensive reference for epidemiologists, public health specialists, practitioners and advocates of STD and HIV prevention, and reproductive and neonatal health.

How did menopause change from being a natural (and often welcome) end to a woman's childbearing years to a deficiency disease in need of medical and pharmacological intervention? As she traces the medicalization of menopause over the last 100 years, historian Judith Houck challenges some widely held assumptions. Physicians hardly foisted hormones on reluctant female patients; rather, physicians themselves were often reluctant to claim menopause as a medical problem and resisted the widespread use of hormone therapy for what was, after all, a normal transition in a woman's lifespan. Houck argues that the medical and popular understandings of menopause at any given time depended on both pharmacological options and cultural ideas and anxieties of the moment. As women delayed marriage and motherhood and entered the workforce in greater numbers, the medical understanding, cultural meaning, and experience of menopause changed. By examining the history of menopause over the course of the twentieth century, Houck shows how the experience and representation of menopause has been profoundly influenced by biomedical developments and by changing roles for women and the changing definition of womanhood.

If not for a horse, would Alexander have been the Great? William, the Conqueror? Richard, the Lionhearted? If not for their awesome mounts, would the Spaniards have had their way with the New World? Would Paul Revere have spread the word? Would the West have been won?

It is hard to comprehend how far horse power has carried us, difficult to imagine, in our era of mechanical wizardry and speed, what role the horse has played in shaping human history. This is the challenge Juliet Clutton-Brock takes up in her book, a splendid blend of natural and social history that recounts the horse's story as it has figured in—and transfigured—our own.

By drawing on biological, archaeological, and historical evidence, Clutton-Brock describes the wild horse and the wild ass, from their widespread distribution at the end of the last Ice Age to their near extinction today. She shows how these beasts, once hunted for meat, were drafted for work and domesticated as humans began to grasp the possibilities of riding horseback. This discovery, with the speed, distance, and power it offered, transformed the course of history. This elegant tale of the horse and donkey, wonderfully written and handsomely illustrated, revives the true meaning of "horse power."

Historians have long assumed that new industrial machines and power sources eliminated work animals from nineteenth-century America, yet a bird’s-eye view of nineteenth-century society would show millions of horses supplying the energy necessary for industrial development. Horses were ubiquitous in cities and on farms, providing power for transportation, construction, manufacturing, and agriculture. On Civil War battlefields, thousands of horses labored and died for the Union and the Confederacy hauling wagons and mechanized weaponry.

The innovations that brought machinery to the forefront of American society made horses the prime movers of these machines for most of the nineteenth century. Mechanization actually increased the need for horsepower by expanding the range of tasks requiring it. Indeed, the single most significant energy transition of the antebellum era may have been the dramatic expansion in the use of living, breathing horses as a power technology in the development of industrial America.

Ann Greene argues for recognition of horses’ critical contribution to the history of American energy and the rise of American industrial power, and a new understanding of the reasons for their replacement as prime movers. Rather than a result of “inevitable” technological change, it was Americans’ social and political choices about power consumption that sealed this animal’s fate. The rise and fall of the workhorse was defined by the kinds of choices that Americans made and would continue to make—choices that emphasized individual mobility and autonomy, and assumed, above all, abundant energy resources.

Love Canal. We hear these words and quickly recoil, remembering a community poisoned by toxic waste. Twenty years after the incident, Allan Mazur reexamines the circumstances that made this upstate New York neighborhood synonymous with ecological catastrophe and triggered federal "Superfund" legislation to clean up the nation's thousands of hazardous waste sites.

But is there only one true story of Love Canal? Borrowing the multi-viewpoint technique of the classic Japanese film Rashomon, Mazur's book reveals that there are many--often conflicting versions of what occurred at Love Canal. Hooker Chemical Company, which deposited the toxic wastes, explains why it subsequently donated the dump as the site for a new school. Lois Gibbs, whose son attended the school, tells of organizing the community to fight both the chemical threat and the uncaring state bureaucracy. Then there is the story of David Axelrod, New York's embattled commissioner of health, at odds with the homeowners over their assessment of the hazards and the proper extent of the state's response. We also hear from Michael Brown, the young reporter who developed the story in the Niagara Gazette and eventually brought the problem of toxic waste to national attention.

If A Hazardous Inquiry succeeded only in making us understand why one version of the events at Love Canal gained precedence over all others, it would be invaluable to policy makers, journalists, scientists, environmentalists, lawyers, and to citizens caught up in technical controversies that get played out (for better or worse) in the public arena. But the book moves beyond that to evaluate and reconcile the conflicting accounts of Love Canal, giving us a fuller, if more complex, picture than ever before. Through gripping personal tales, A Hazardous Inquiry tells how politics and journalism and epidemiology sometimes mesh, but often clash, when confronting a potential community disaster.

This volume analyzes the politics of hazardous waste siting and explores promising new strategies for siting facilities. Existing approaches to waste siting facilities have almost entirely failed, across all industrialized countries, largely because of community or NIMBY (Not in My Backyard) opposition. This volume examines a new strategy, voluntary choice siting—a process requiring mutual decisions negotiated between facility developers and the host communities. This bottom-up approach preserves democratic rights, recognizes the importance of public perceptions, and addresses issues of equity.

In this collection, an interdisciplinary group of experts probes recent examples of waste facilities siting in the United States, Canada, Germany, and Japan. Both the successes and the failures presented offer practical insights into the siting process. The book includes an introductory review of the literature on facility siting and the NIMBY phenomenon as well as instructive essays on the use of voluntary processes in facilities siting.

This book will be of value to policymakers, industry, and environmental groups, as well as to those working in environmental studies and engineering, political science, public health, geography, planning, and business economics.

• Authored by a multi-national group of antenna experts of international standing.
• Presents the principles and applications of antenna design, with emphasis upon key developments in the last 15 years.
• Fundamental background theory and analytical techniques explained in detail where appropriate.
• Includes extensive design data and numerous examples of practical application.
• Deals with a very wide range of antenna types, operating from very low frequencies to millimetre waves.
• New measurement techniques described in detail.
• Covers associated topics such as radomes, array signal processing and coaxial components.
• Includes design data for antennas for satellite and terrestrial communications, radar, mobile communications and broadcasting.

• Authored by a multi-national group of antenna experts of international standing.
• Presents the principles and applications of antenna design, with emphasis upon key developments in the last 15 years.
• Fundamental background theory and analytical techniques explained in detail where appropriate.
• Includes extensive design data and numerous examples of practical application.
• Deals with a very wide range of antenna types, operating from very low frequencies to millimetre waves.
• New measurement techniques described in detail.
• Covers associated topics such as radomes, array signal processing and coaxial components.
• Includes design data for antennas for satellite and terrestrial communications, radar, mobile communications and broadcasting.