With Biotechnology and Society, Hallam Stevens offers an up-to-date primer to help us understand the interactions of biotechnology and society and the debates, controversies, fears, and hopes that have shaped how we think about bodies, organisms, and life in the twenty-first century. Stevens addresses such topics as genetically modified foods, cloning, and stem cells; genetic testing and the potential for discrimination; fears of (and, in some cases, hopes for) designer babies; personal genomics; biosecurity; and biotech art. Taken as a whole, the book presents a clear, authoritative picture of the relationship between biotechnology and society today, and how our conceptions (and misconceptions) of it could shape future developments. It is an essential volume for students and scholars working with biotechnology, while still being accessible to the general reader interested in the truth behind breathless media accounts about biotech’s promise and perils.

What might the cinema tell us about how and why the prospect of cloning disturbs our most profound ideas about gender, sexuality, difference, and the body? In The Cinematic Life of the Gene, the pioneering feminist film theorist Jackie Stacey argues that as a cultural technology of imitation, cinema is uniquely situated to help us theorize “the genetic imaginary,” the constellation of fantasies that genetic engineering provokes. Since the mid-1990s there has been remarkable innovation in genetic engineering and a proliferation of films structured by anxieties about the changing meanings of biological and cultural reproduction. Bringing analyses of several of these films into dialogue with contemporary cultural theory, Stacey demonstrates how the cinema animates the tropes and enacts the fears at the heart of our genetic imaginary. She engages with film theory; queer theories of desire, embodiment, and kinship; psychoanalytic theories of subject formation; and debates about the reproducibility of the image and the shift from analog to digital technologies.

Stacey examines the body-horror movies Alien: Resurrection and Species in light of Jean Baudrillard’s apocalyptic proclamations about cloning and “the hell of the same,” and she considers the art-house thrillers Gattaca and Code 46 in relation to ideas about imitation, including feminist theories of masquerade, postcolonial conceptualizations of mimicry, and queer notions of impersonation. Turning to Teknolust and Genetic Admiration, independent films by feminist directors, she extends Walter Benjamin’s theory of aura to draw an analogy between the replication of biological information and the reproducibility of the art object. Stacey suggests new ways to think about those who are not what they appear to be, the problem of determining identity in a world of artificiality, and the loss of singularity amid unchecked replication.

It was only around 1800 that heredity began to enter debates among physicians, breeders, and naturalists. Soon thereafter it evolved into one of the most fundamental concepts of biology. Here Staffan Müller-Wille and Hans-Jörg Rheinberger offer a succinct cultural history of the scientific concept of heredity. They outline the dramatic changes the idea has undergone since the early modern period and describe the political and technological developments that brought about these changes.

Müller-Wille and Rheinberger begin with an account of premodern theories of generation, showing that these were concerned with the procreation of individuals rather than with hereditary transmission. The authors reveal that when hereditarian thinking first emerged, it did so in a variety of cultural domains, such as politics and law, medicine, natural history, breeding, and anthropology. Müller-Wille and Rheinberger then track theories of heredity from the late nineteenth century—when leading biologists considered it in light of growing societal concerns with race and eugenics—through the rise of classical and molecular genetics in the twentieth century, to today, as researchers apply sophisticated information technologies to understand heredity. What readers come to see from this exquisite history is why it took such a long time for heredity to become a prominent concept in the life sciences and why it gained such overwhelming importance in those sciences and the broader culture over the last two centuries.

While the creation of Dolly the sheep, the world's most famous clone, triggered an enormous amount of discussion about human cloning, in Dolly Mixtures the anthropologist Sarah Franklin looks beyond that much-rehearsed controversy to some of the other reasons why the iconic animal's birth and death were significant. Building on the work of historians and anthropologists, Franklin reveals Dolly as the embodiment of agricultural, scientific, social, and commercial histories which are, in turn, bound up with national and imperial aspirations. Dolly was the offspring of a long tradition of animal domestication, as well as the more recent histories of capital accumulation through selective breeding, and enhanced national competitiveness through the control of biocapital. Franklin traces Dolly's connections to Britain's centuries-old sheep and wool markets (which were vital to the nation's industrial revolution) and to Britain's export of animals to its colonies—particularly Australia—to expand markets and produce wealth. Moving forward in time, she explains the celebrity sheep's links to the embryonic cell lines and global bioscientific innovation of the late twentieth century and early twenty-first.

Franklin combines wide-ranging sources—from historical accounts of sheep-breeding, to scientific representations of cloning by nuclear transfer, to popular media reports of Dolly's creation and birth—as she draws on gender and kinship theory as well as postcolonial and science studies. She argues that there is an urgent need for more nuanced responses to the complex intersections between the social and the biological, intersections which are literally reshaping reproduction and genealogy. In Dolly Mixtures, Franklin uses the renowned sheep as an opportunity to begin developing a critical language to identify and evaluate the reproductive possibilities that post-Dolly biology now faces, and to look back at some of the important historical formations that enabled and prefigured Dollys creation.

Devised in the 1940s by the biologist C. H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the late 1960s but returned at the beginning of the twenty-first century with the advent of big-data genomic research because of its utility among scientists across the life sciences to think more creatively about and to discuss genetics. In Epigenetic Landscapes Susan Merrill Squier follows the model’s cultural trail, from its first visualization by the artist John Piper to its use beyond science. Squier examines three cases in which the metaphor has been imaginatively deployed to illustrate complex systems that link scientific and cultural practices: graphic medicine, landscape architecture, and bioArt. Challenging reductive understandings of epigenetics, Squier boldly reclaims the broader significance of the epigenetic landscape as a figure at the nexus of art, design, and science.

"Wright's views about population genetics and evolution are so fundamental and so comprehensive that every serious student must examine these books firsthand. . . . Publication of this treatise is a major event in evolutionary biology."-Daniel L. Hartl, BioScience

"Wright's views about population genetics and evolution are so fundamental and so comprehensive that every serious student must examine these books firsthand. . . . Publication of this treatise is a major event in evolutionary biology."-Daniel L. Hartl, BioScience

"Wright's views about population genetics and evolution are so fundamental and so comprehensive that every serious student must examine these books firsthand. . . . Publication of this treatise is a major event in evolutionary biology."-Daniel L. Hartl, BioScience

In recent decades, Susan Oyama and her colleagues in the burgeoning field of developmental systems theory have rejected the determinism inherent in the nature/nurture debate, arguing that behavior cannot be reduced to distinct biological or environmental causes. In Evolution’s Eye Oyama elaborates on her pioneering work on developmental systems by spelling out that work’s implications for the fields of evolutionary theory, developmental and social psychology, feminism, and epistemology. Her approach profoundly alters our understanding of the biological processes of development and evolution and the interrelationships between them.
While acknowledging that, in an uncertain world, it is easy to “blame it on the genes,” Oyama claims that the renewed trend toward genetic determinism colors the way we think about everything from human evolution to sexual orientation and personal responsibility. She presents instead a view that focuses on how a wide variety of developmental factors interact in the multileveled developmental systems that give rise to organisms. Shifting attention away from genes and the environment as causes for behavior, she convincingly shows the benefits that come from thinking about life processes in terms of developmental systems that produce, sustain, and change living beings over both developmental and evolutionary time.
Providing a genuine alternative to genetic and environmental determinism, as well as to unsuccessful compromises with which others have tried to replace them, Evolution’s Eye will fascinate students and scholars who work in the fields of evolution, psychology, human biology, and philosophy of science. Feminists and others who seek a more complex view of human nature will find her work especially congenial.

In 1993, an American biotechnology company and a French genetics lab developed a collaborative research plan to search for diabetes genes. But just as the project was to begin, the French government called it to a halt, barring the laboratory from sharing something never previously thought of as a commodity unto itself: French DNA.

Few concepts played a more important role in twentieth-century life sciences than that of the gene. Yet at this moment, the field of genetics is undergoing radical conceptual transformation, and some scientists are questioning the very usefulness of the concept of the gene, arguing instead for more systemic perspectives.
 
The time could not be better, therefore, for Hans-Jörg Rheinberger and Staffan Müller-Wille's magisterial history of the concept of the gene. Though the gene has long been the central organizing theme of biology, both conceptually and as an object of study, Rheinberger and Müller-Wille conclude that we have never even had a universally accepted, stable definition of it. Rather, the concept has been in continual flux—a state that, they contend, is typical of historically important and productive scientific concepts. It is that very openness to change and manipulation, the authors argue, that made it so useful: its very mutability enabled it to be useful while the technologies and approaches used to study and theorize about it changed dramatically.
 

In light of scientific advances such as genomics, predictive diagnostics, genetically engineered agriculture, nuclear transfer cloning, and the manipulation of stem cells, the idea that genes carry predetermined molecular programs or blueprints is pervasive. Yet new scientific discoveries—such as rna transcripts of single genes that can lead to the production of different compounds from the same pieces of dna—challenge the concept of the gene alone as the dominant factor in biological development. Increasingly aware of the tension between certain empirical results and interpretations of those results based on the orthodox view of genetic determinism, a growing number of scientists urge a rethinking of what a gene is and how it works. In this collection, a group of internationally renowned scientists present some prominent alternative approaches to understanding the role of dna in the construction and function of biological organisms.

Contributors discuss alternatives to the programmatic view of dna, including the developmental systems approach, methodical culturalism, the molecular process concept of the gene, the hermeneutic theory of description, and process structuralist biology. None of the approaches cast doubt on the notion that dna is tremendously important to biological life on earth; rather, contributors examine different ideas of how dna should be represented, evaluated, and explained. Just as ideas about genetic codes have reached far beyond the realm of science, the reconceptualizations of genetic theory in this volume have broad implications for ethics, philosophy, and the social sciences.

Contributors. Thomas Bürglin, Brian C. Goodwin, James Griesemer, Paul Griffiths, Jesper Hoffmeyer, Evelyn Fox Keller, Gerd B. Müller, Eva M. Neumann-Held, Stuart A. Newman, Susan Oyama, Christoph Rehmann-Sutter, Sahotra Sarkar, Jackie Leach Scully, Gerry Webster, Ulrich Wolf

A classic study of dog behavior gathered into one volume, this is the single most important and comprehensive reference work on the behavior of dogs ever complied.

Scott and Fuller’s classic study of dog behavior gathers into one volume the authoritative information that came from their twenty years of research at the Jackson Laboratory. Central to their book is the role heredity plays in the development of behavior. Giving puppies an environment designed on the principles of a well-run school, Scott and Fuller tested five breeds representing the major dog groups and carried out a Mendelian experiment with two of the most different breeds: the basenji and the cocker spaniel.
 
They found that heredity affects almost every trait tested; that sex affects aggressiveness and the dominance order, but not trainability and problem-solving; that emotional traits profoundly influence performance; that, although breeds differ widely in emotional and motivational characteristics, none shows distinct superiority in problem solving; and that detailed statistical analyses indicate a highly complex pathway between primary gene action and its final effect on behavior.
 
Included is important information on:
 
• rearing methods
• the origin and history of dog breeds
• basic behavior patterns
• the physiological and behavioral development of puppies

Pulitzer Prize-winning author Louis Menand begins this wide-ranging volume with an essay that extols diversity and warns of the dangers of modifying the human genome. Nora Groce reviews the ways that societies have defined disability and creates an interpretive framework for discussing the relationship between culture and disability.

     In essays devoted to historical perspective, Brian H. Greenwald comments upon the real “toll” taken by A. G. Bell’s insistence upon oralism, while Joseph J. Murray weighs the nineteenth-century debate over whether deaf-deaf marriages should be encouraged. John S. Schuchman’s chilling account of deafness and eugenics in the Nazi era adds wrenching reinforcement to the impetus to include disabled people in genetics debates.

     Mark Willis offers an intensely personal reflection on the complexities of genetic alteration, addressing both his heart condition and his blindness in surprisingly different ways. Anna Middleton extends Willis’s concepts in her discussion of couples currently considering the use of genetic knowledge and technology to select for or against a gene that causes deafness.

     In the part on the science of genetics, Orit Dagan, Karen B. Avraham, Kathleen S. Arnos, and Arti Pandya clarify the choices presented by genetic engineering, and geneticist Walter E. Nance emphasizes the importance of science in offering individuals knowledge from which they can fashion their own decisions. In the concluding section, Christopher Krentz raises moral questions about the ever-continuing search for human perfection, and Michael Bérubé argues that disability should be considered democratically to ensure full participation of disabled people in all decisions that might affect them.

For much of the twentieth century scientists sought to explain objects and processes by reducing them to their components—nuclei into protons and neutrons, proteins into amino acids, and so on—but over the past forty years there has been a marked turn toward explaining phenomena by building them up rather than breaking them down. This collection reflects on the history and significance of this turn toward “growing explanations” from the bottom up. The essays show how this strategy—based on a widespread appreciation for complexity even in apparently simple processes and on the capacity of computers to simulate such complexity—has played out in a broad array of sciences. They describe how scientists are reordering knowledge to emphasize growth, change, and contingency and, in so doing, are revealing even phenomena long considered elementary—like particles and genes—as emergent properties of dynamic processes.

Written by leading historians and philosophers of science, these essays examine the range of subjects, people, and goals involved in changing the character of scientific analysis over the last several decades. They highlight the alternatives that fields as diverse as string theory, fuzzy logic, artificial life, and immunology bring to the forms of explanation that have traditionally defined scientific modernity. A number of the essays deal with the mathematical and physical sciences, addressing concerns with hybridity and the materials of the everyday world. Other essays focus on the life sciences, where questions such as “What is life?” and “What is an organism?” are undergoing radical re-evaluation. Together these essays mark the contours of an ongoing revolution in scientific explanation.

Contributors. David Aubin, Amy Dahan Dalmedico, Richard Doyle, Claus Emmeche, Peter Galison, Stefan Helmreich, Ann Johnson, Evelyn Fox Keller, Ilana Löwy, Claude Rosental, Alfred Tauber

What makes us alive? Is it our DNA? Our genetics? Is it our atomic composition that gives us life? Somehow, all of this feels radically dissonant from our everyday experience. In Life Beyond Molecules and Genes, experimental biologist Stephen Rothman makes the bold case that it is, in fact, our adaptive abilities, hewn by evolution, that make us alive. In making this point, he reveals a hidden harmony between science and life as we live it.

 

People have searched for the fountain of youth everywhere from Bimini to St. Augustine. But for a steadfast group of scientists, the secret to a long life lies elsewhere: in the lowly lab worm. By suppressing the function of just a few key genes, these scientists were able to lengthen worms’ lifespans up to tenfold, while also controlling the onset of many of the physical problems that beset old age. As the global population ages, the potential impact of this discovery on society is vast—as is the potential for profit.

With The Longevity Seekers, science writer Ted Anton takes readers inside this tale that began with worms and branched out to snare innovative minds from California to Crete, investments from big biotech, and endorsements from TV personalities like Oprah and Dr. Oz. Some of the research was remarkable, such as the discovery of an enzyme in humans that stops cells from aging. And some, like an oft-cited study touting the compound resveratrol, found in red wine—proved highly controversial, igniting a science war over truth, credit, and potential profit. As the pace of discovery accelerated, so too did powerful personal rivalries and public fascination, driven by the hope that a longer, healthier life was right around the corner. Anton has spent years interviewing and working with the scientists at the frontier of longevity science, and this book offers a behind-the-scenes look at the state-of-the-art research and the impact it might have on global public health, society, and even our friends and family.

With spectacular science and an unforgettable cast of characters, The Longevity Seekers has all the elements of a great story and sheds light on discoveriesthat could fundamentally reshape human life.

 

The common fruit fly, Drosophila, has long been one of the most productive of all laboratory animals. From 1910 to 1940, the center of Drosophila culture in America was the school of Thomas Hunt Morgan and his students Alfred Sturtevant and Calvin Bridges. They first created "standard" flies through inbreeding and by organizing a network for exchanging stocks of flies that spread their practices around the world.

In Lords of the Fly, Robert E. Kohler argues that fly laboratories are a special kind of ecological niche in which the wild fruit fly is transformed into an artificial animal with a distinctive natural history. He shows that the fly was essentially a laboratory tool whose startling productivity opened many new lines of genetic research. Kohler also explores the moral economy of the "Drosophilists": the rules for regulating access to research tools, allocating credit for achievements, and transferring authority from one generation of scientists to the next.

By closely examining the Drosophilists' culture and customs, Kohler reveals essential features of how experimental scientists do their work.

Making PCR is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time—the polymerase chain reaction. Transforming the practice and potential of molecular biology, PCR extends scientists' ability to identify and manipulate genetic materials and accurately reproduces millions of copies of a given segment in a short period of time. It makes abundant what was once scarce—the genetic material required for experimentation.

Making PCR explores the culture of biotechnology as it emerged at Certus Corporation during the 1980s and focuses on its distinctive configuration of scientific, technical, social, economic, political, and legal elements, each of which had its own separate trajectory over the preceding decade. The book contains interviews with the remarkable cast of characters who made PCR, including Kary Mullin, the maverick who received the Nobel prize for "discovering" it, as well as the team of young scientists and the company's business leaders.

This book shows how a contingently assembled practice emerged, composed of distinctive subjects, the site where they worked, and the object they invented.

"Paul Rabinow paints a . . . picture of the process of discovery in Making PCR: A Story of Biotechnology [and] teases out every possible detail. . . . Makes for an intriguing read that raises many questions about our understanding of the twisting process of discovery itself."—David Bradley, New Scientist

"Rabinow's book belongs to a burgeoning genre: ethnographic studies of what scientists actually do in the lab. . . . A bold move."—Daniel Zalewski, Lingua Franca

"[Making PCR is] exotic territory, biomedical research, explored. . . . Rabinow describes a dance: the immigration and repatriation of scientists to and from the academic and business worlds."—Nancy Maull, New York Times Book Review

In genetics laboratories in Latin America, scientists have been mapping the genomes of local populations, seeking to locate the genetic basis of complex diseases and to trace population histories. As part of their work, geneticists often calculate the European, African, and Amerindian genetic ancestry of populations. Some researchers explicitly connect their findings to questions of national identity and racial and ethnic difference, bringing their research to bear on issues of politics and identity.

Drawing on ethnographic research in Brazil, Colombia, and Mexico, the contributors to Mestizo Genomics explore how the concepts of race, ethnicity, nation, and gender enter into and are affected by genomic research. In Latin America, national identities are often based on ideas about mestizaje (race mixture), rather than racial division. Since mestizaje is said to involve relations between European men and indigenous or African women, gender is a key factor in Latin American genomics and in the analyses in this book. Also important are links between contemporary genomics and recent moves toward official multiculturalism in Brazil, Colombia, and Mexico. One of the first studies of its kind, Mestizo Genomics sheds new light on the interrelations between "race," identity, and genomics in Latin America.

Contributors. Adriana Díaz del Castillo H., Roosbelinda Cárdenas, Vivette García Deister, Verlan Valle Gaspar Neto, Michael Kent, Carlos López Beltrán, María Fernanda Olarte Sierra, Eduardo Restrepo, Mariana Rios Sandoval, Ernesto Schwartz-Marín, Ricardo Ventura Santos, Peter Wade

The promise of genetic engineering in the early 1970s to profoundly reshape the living world activated a variety of social interests in its future promotion and control. With public safety, gene patents, and the future of genetic research at stake, a wide range of interest groups competed for control over this powerful new technology.

In this comparative study of the development of regulatory policy for genetic engineering in the United States and the United Kingdom, Susan Wright analyzes government responses to the struggles among corporations, scientists, universities, trade unions, and public interest groups over regulating this new field. Drawing on archival materials, government records, and interviews with industry executives, politicians, scientists, trade unionists, and others on both sides of the Atlantic, Molecular Politics provides a comprehensive account of a crucial set of policy decisions and explores their implications for the political economy of science.

By combining methods from political science and the history of science, Wright advances a provocative interpretation of the evolution of genetic engineering policy and makes a major contribution to science and public policy studies.

Inbreeding, the mating of close kin, and outbreeding, the mating of distant relatives or unrelated organisms, have long been important subjects to evolutionary biologists. Inbreeding reduces genetic diversity in a population, increasing the likelihood that genetic defects will become widespread and deprive a population of the diversity it may need to cope with its environment. Most plants and animals have evolved behavioral and morphological mechanisms to avoid inbreeding. However, today many endangered species exist only in small, very isolated populations where inbreeding is unavoidable, so it has become a concern for conservationists. In this volume, twenty-six experts in evolution, behavior, and genetics examine the causes and consequences of inbreeding.

The authors ask whether inbreeding is as problematic as biologists have thought, under what ecological conditions inbreeding occurs, and whether organisms that inbreed have mechanisms to dampen the anticipated problems of reduced genetic variation. The studies, including theoretical and empirical work on wild and captive populations, demonstrate that many plants and animals inbreed to a greater extent than biologists have thought, with variable effects on individual fitness. Graduate students and researchers in evolutionary biology, animal behavior, ecology, and conservation biology will welcome this wide-ranging collection.

Ordinary Genomes is an ethnography of genomics, a global scientific enterprise, as it is understood and practiced in the Netherlands. Karen-Sue Taussig’s analysis of the Dutch case illustrates how scientific knowledge and culture are entwined: Genetics may transform society, but society also transforms genetics. Taussig traces the experiences of Dutch people as they encounter genetics in research labs, clinics, the media, and everyday life. Through vivid descriptions of specific diagnostic processes, she illuminates the open and evolving nature of genetic categories, the ways that abnormal genetic diagnoses are normalized, and the ways that race, ethnicity, gender, and religion inform diagnoses. Taussig contends that in the Netherlands ideas about genetics are shaped by the desire for ordinariness and the commitment to tolerance, two highly-valued yet sometimes contradictory Dutch social ideals, as well as by Dutch history and concerns about immigration and European unification. She argues that the Dutch enable a social ideal of tolerance by demarcating and containing difference so as to minimize its social threat. It is within this particular construction of tolerance that the Dutch manage the meaning of genetic difference.

Technology evolves at a dazzling speed, and nowhere more so than in the field of genetic engineering, where the possibility of directly changing the genes of one's children is quickly becoming a reality. The public is rightly concerned, but interestingly, they have not had much to say about the implications of recent advancements in human genetics.

Playing God? asks why and explores the social forces that have led to the thinning out of public debate over human genetic engineering. John H. Evans contends that the problem lies in the structure of the debate itself. Disputes over human genetic engineering concern the means for achieving assumed ends, rather than being a healthy discussion about the ends themselves. According to Evans, this change in focus occurred as the jurisdiction over the debate shifted from scientists to bioethicists, a change which itself was caused by the rise of the bureaucratic state as the authority in such matters. The implications of this timely study are twofold. Evans not only explores how decisions about the ethics of human genetic engineering are made, but also shows how the structure of the debate has led to the technological choices we now face.

How has DNA come to be seen as a cosmic truth, representative of all life, potential for all cures, repository for all identity, and end to all stories? In The Poetics of DNA, Judith Roof examines the rise of this powerful symbol and the implications of its ascendancy for the ways we think—about ourselves, about one another, and about the universe.

Descriptions of DNA, Roof argues, have distorted ideas and transformed nucleic acid into the answer to all questions of life. This hyperbolized notion of DNA, inevitably confused or conflated with the “gene,” has become a vector through which older ways of thinking can merge with the new, advancing long-discredited and insidious ideas about such things as eugenics and racial selection and influencing contemporary debates, particularly the popular press obsession with the “gay gene.” Through metaphors of DNA, she contends, racist and homophobic ideology is masked as progressive science.

Grappling with twentieth-century intellectual movements as well as contemporary societal anxieties, The Poetics of DNA reveals how descriptions of DNA and genes typify a larger set of epistemological battles that play out not only through the assumptions associated with DNA but also through less evident methods of magical thinking, reductionism, and pseudoscience.

For the first time, Roof exposes the ideology and cultural consequences of DNA and gene metaphors to uncover how, ultimately, they are paradigms used to recreate prejudices.

Judith Roof is professor of English and film studies at Michigan State University. She is the author of several books, including All about Thelma and Eve: Sidekicks and Third Wheels.

One of this century's leading evolutionary biologists, Motoo Kimura revolutionized the field with his random drift theory of molecular evolution—the neutral theory—and his groundbreaking theoretical work in population genetics. This volume collects 57 of Kimura's most important papers and covers forty years of his diverse and original contributions to our understanding of how genetic variation affects evolutionary change.

Kimura's neutral theory, first presented in 1968, challenged the notion that natural selection was the sole directive force in evolution. Arguing that mutations and random drift account for variations at the level of DNA and amino acids, Kimura advanced a theory of evolutionary change that was strongly challenged at first and that eventually earned the respect and interest of evolutionary biologists throughout the world. This volume includes the seminal papers on the neutral theory, as well as many others that cover such topics as population structure, variable selection intensity, the genetics of quantitative characters, inbreeding systems, and reversibility of changes by random drift.

Background essays by Naoyuki Takahata examine Kimura's work in relation to its effects and recent developments in each area.

Now that we have sequenced the human genome, what does it mean? In The Postgenomic Condition, Jenny Reardon critically examines the decade after the Human Genome Project, and the fundamental questions about meaning, value and justice this landmark achievement left in its wake.

Drawing on more than a decade of research—in molecular biology labs, commercial startups, governmental agencies, and civic spaces—Reardon demonstrates how the extensive efforts to transform genomics from high tech informatics practiced by a few to meaningful knowledge beneficial to all exposed the limits of long-cherished liberal modes of knowing and governing life. Those in the American South challenged the value of being included in genomics when no hospital served their community.  Ethicists and lawyers charged with overseeing Scottish DNA and data questioned how to develop a system of ownership for these resources when their capacity to create things of value—new personalized treatments—remained largely unrealized. Molecular biologists who pioneered genomics asked whether their practices of thinking could survive the deluge of data produced by the growing power of sequencing machines. While the media is filled with grand visions of precision medicine, The Postgenomic Condition shares these actual challenges of the scientists, entrepreneurs, policy makers, bioethicists, lawyers, and patient advocates who sought to leverage liberal democratic practices to render genomic data a new source of meaning and value for interpreting and caring for life. It brings into rich empirical focus the resulting hard on-the-ground questions about how to know and live on a depleted but data-rich, interconnected yet fractured planet, where technoscience garners significant resources, but deeper questions of knowledge and justice urgently demand attention.

Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences.

Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens

Quantitative genetics—the statistical study of the inheritance of traits within a population—has become an important tool for studying the evolution of behavior in the last decade. Quantitative Genetic Studies of Behavioral Evolution examines the theory and methods of quantitative genetics and presents case studies that illustrate the many ways in which the methods can be applied.

Christine R. B. Boake brings together current theoretical and empirical studies to show how quantitative genetics can illuminate topics as diverse as sexual selection, migration, sociality, and aggressive behavior. Nearly half of the chapters focus on conceptual issues, ranging from quantitative genetic models to the complementary roles of quantitative genetic and optimality approaches in evolutionary studies. Other chapters illustrate how to use the techniques by providing surveys of research fields, such as the evolution of mating behavior, sexual selection, migration, and size-dependent behavioral variation. The balance of the volume offers case studies of territoriality in fruit flies, cannibalism in flour beetles, mate-attractive traits in crickets, locomotor behavior and physiology in the garter snake, and cold adaptation in the house mouse. Taken together, these studies document both the benefits and pitfalls of quantitative genetics.

This book shows the advanced student and scholar of behavioral evolution and genetics the many powerful uses of quantitative genetics in behavioral research.

Human genomes are 99.9 percent identical—with one prominent exception. Instead of a matching pair of X chromosomes, men carry a single X, coupled with a tiny chromosome called the Y. Tracking the emergence of a new and distinctive way of thinking about sex represented by the unalterable, simple, and visually compelling binary of the X and Y chromosomes, Sex Itself examines the interaction between cultural gender norms and genetic theories of sex from the beginning of the twentieth century to the present, postgenomic age.

           

Using methods from history, philosophy, and gender studies of science, Sarah S. Richardson uncovers how gender has helped to shape the research practices, questions asked, theories and models, and descriptive language used in sex chromosome research. From the earliest theories of chromosomal sex determination, to the mid-century hypothesis of the aggressive XYY supermale, to the debate about Y chromosome degeneration, to the recent claim that male and female genomes are more different than those of humans and chimpanzees, Richardson shows how cultural gender conceptions influence the genetic science of sex. 

           

Richardson shows how sexual science of the past continues to resonate, in ways both subtle and explicit, in contemporary research on the genetics of sex and gender. With the completion of the Human Genome Project, genes and chromosomes are moving to the center of the biology of sex. Sex Itself offers a compelling argument for the importance of ongoing critical dialogue on how cultural conceptions of gender operate within the science of sex.

Rudolf Raff is recognized as a pioneer in evolutionary developmental biology. In their 1983 book, Embryos, Genes, and Evolution, Raff and co-author Thomas Kaufman proposed a synthesis of developmental and evolutionary biology. In The Shape of Life, Raff analyzes the rise of this new experimental discipline and lays out new research questions, hypotheses, and approaches to guide its development.

Raff uses the evolution of animal body plans to exemplify the interplay between developmental mechanisms and evolutionary patterns. Animal body plans emerged half a billion years ago. Evolution within these body plans during this span of time has resulted in the tremendous diversity of living animal forms.

Raff argues for an integrated approach to the study of the intertwined roles of development and evolution involving phylogenetic, comparative, and functional biology. This new synthesis will interest not only scientists working in these areas, but also paleontologists, zoologists, morphologists, molecular biologists, and geneticists.

In this detailed historical and sociological study of the development of scientific ideas, Jonathan Harwood argues that there is no such thing as a unitary scientific method driven by an internal logic. Rather, there are national styles of science that are defined by different values, norms, assumptions, research traditions, and funding patterns.

The first book-length treatment of genetics in Germany, Styles of Scientific Thought demonstrates the influence of culture on science by comparing the American with the German scientific traditions. Harwood examines the structure of academic and research institutions, the educational backgrounds of geneticists, and cultural traditions, among many factors, to explain why the American approach was much more narrowly focussed than the German.

This tremendously rich book fills a gap between histories of the physical sciences in the Weimar Republic and other works on the humanities and the arts during the intellectually innovative 1920s, and it will interest European historians, as well as sociologists and philosophers of science.

Darwin’s nineteenth-century writings laid the foundations for modern studies of evolution, and theoretical developments in the mid-twentieth century fostered the Modern Synthesis. Since that time, a great deal of new biological knowledge has been generated, including details of the genetic code, lateral gene transfer, and developmental constraints. Our improved understanding of these and many other phenomena have been working their way into evolutionary theory, changing it and improving its correspondence with evolution in nature. And while the study of evolution is thriving both as a basic science to understand the world and in its applications in agriculture, medicine, and public health, the broad scope of evolution—operating across genes, whole organisms, clades, and ecosystems—presents a significant challenge for researchers seeking to integrate abundant new data and content into a general theory of evolution.

This book gives us that framework and synthesis for the twenty-first century. The Theory of Evolution presents a series of chapters by experts seeking this integration by addressing the current state of affairs across numerous fields within evolutionary biology, ranging from biogeography to multilevel selection, speciation, and macroevolutionary theory. By presenting current syntheses of evolution’s theoretical foundations and their growth in light of new datasets and analyses, this collection will enhance future research and understanding.