In 1985 the media announced a new therapy for cancer. It was expensive, labor-intensive, and toxic--but, they said, it worked. How it worked is the story Ilana Löwy tells in Between Bench and Bedside, a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Her book offers a remarkable insider's view of the culture of clinical experimentation in oncology--and of how this culture affects the development of new treatments for cancer.

Löwy, a historian of science who trained as an immunologist, makes the life of the laboratory and the hospital comprehensible and immediate. Before immersing us in the clinical drama, she fills in the history behind the action--a background of chemotherapy and radiation, controlled clinical trials, and the long line of immunological approaches that finally led to interleukin-2. The story then shifts to the introduction of interleukin-2 in a cancer ward. Löwy conveys the clinical investigation as a complex, multilayered phenomenon that defies the stereotypes of modern biomedicine. In this picture, the miracle-makers and arrogant, self-centered professionals of myth give way to moving images of real people negotiating the tensions between institutional and professional constraints, the search for a scientific breakthrough, and the obligation to alleviate the suffering of a patient. The result is a rare firsthand look at the multiple factors that shape real-life clinical experiments and the institutional tangle and emotional muddle that surround such trials--an invaluable view at a time when medicine is undergoing such great and confusing changes.

In a newly enlarged edition of this eye-opening book, David T. Courtwright offers an original interpretation of a puzzling chapter in American social and medical history: the dramatic change in the pattern of opiate addiction--from respectable upper-class matrons to lower-class urban males, often with a criminal record. Challenging the prevailing view that the shift resulted from harsh new laws, Courtwright shows that the crucial role was played by the medical rather than the legal profession.

Dark Paradise tells the story not only from the standpoint of legal and medical sources, but also from the perspective of addicts themselves. With the addition of a new introduction and two new chapters on heroin addiction and treatment since 1940, Courtwright has updated this compelling work of social history for the present crisis of the Drug War.

Franz Rosenzweig, one of the century’s great Jewish thinkers, wrote his gem of a book in 1921 as a more accessible précis of his famous Star of Redemption. An elegant introduction to Rosenzweig’s “new thinking,” Understanding the Sick and the Healthy was written for a lay audience and takes the form of an ironic narrative about convalescence. With superb simplicity and beauty, it puts forth an important critique of the nineteenth-century German Idealist philosophical tradition and expresses a powerful vision of Jewish religion. Harvard’s Hilary Putnam provides a new introduction to this classic work for a contemporary audience.

“Today, more than three-quarters of a century after it was written, the critique of philosophy in this book is what makes it of such great interest. Critique of philosophy has been a central theme of twentieth-century philosophy, and many philosophers have attacked some of the targets that Rosenzweig attacked in his little book. Yet this early attack by a profound religious thinker is far more powerful and far more interesting than most.”—From the new Introduction by Hilary Putnam