Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.

Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.

By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

Honorable Mention, Ramirez Family Award for Most Significant Scholarly Book, Texas Institute of Letters, 2019

Jim Wright made his mark on virtually every major public policy issue in the later twentieth century—energy, education, taxes, transportation, environmental protection, civil rights, criminal justice, and foreign relations, among them. He played a significant role in peace initiatives in Central America and in the Camp David Accords, and he was the first American politician to speak live on Soviet television. A Democrat representing Texas’s twelfth district (Fort Worth), Wright served in the US House of Representatives from the Eisenhower administration to the presidency of George H. W. Bush, including twelve years (1977–1989) as majority leader and speaker. His long congressional ascension and sudden fall in a highly partisan ethics scandal spearheaded by Newt Gingrich mirrored the evolution of Congress as an institution.

Speaker Jim Wright traces the congressman’s long life and career in a highly readable narrative grounded in extensive interviews with Wright and access to his personal diaries. A skilled connector who bridged the conservative and liberal wings of the Democratic party while forging alliances with Republicans to pass legislation, Wright ultimately fell victim to a new era of political infighting, as well as to his own hubris and mistakes. J. Brooks Flippen shows how Wright’s career shaped the political culture of Congress, from its internal rules and power structure to its growing partisanship, even as those new dynamics eventually contributed to his political demise. To understand Jim Wright in all his complexity is to understand the story of modern American politics.

An anonymous minstrel in thirteenth-century France composed this gripping account of historical events in his time. Crusaders and Muslim forces battle for control of the Holy Land, while power struggles rage between and among religious authorities and their conflicting secular counterparts, pope and German emperor, the kings of England and the kings of France. Meanwhile, the kings cannot count on their independent-minded barons to support or even tolerate the royal ambitions. Although politics (and the collapse of a royal marriage) frame the narrative, the logistics of war are also in play: competing military machinery and the challenges of transporting troops and matariel. Inevitably, the civilian population suffers. The minstrel was a professional story-teller, and his livelihood likely depended on his ability to captivate an audience. Beyond would-be objective reporting, the minstrel dramatizes events through dialogue, while he delves into the motives and intentions of important figures, and imparts traditional moral guidance. We follow the deeds of many prominent women and witness striking episodes in the lives of Eleanor of Aquitaine, Richard the Lionhearted, Blanche of Castile, Frederick the Great, Saladin, and others. These tales survive in several manuscripts, suggesting that they enjoyed significant success and popularity in their day. Samuel N. Rosenberg produced this first scholarly translation of the Old French tales into English. References that might have been obvious to the minstrel’s original audience are explained for the modern reader in the indispensable annotations of medieval historian Randall Todd Pippenger. The introduction by eminent medievalist William Chester Jordan places the minstrel’s work in historical context and discusses the surviving manuscript sources.

In this new volume, two lawyers debate which kind of automobile insurance is the best, no-fault or tort liability. This book presents in one place all the legal, political, historical, and financial arguments about the two types of auto insurance.

Under the fault system currently used by thirty-seven states, tort law provides that the party at fault in the accident pays the full damages of accident victims. Jerry J. Phillips favors this system, arguing that it allows for fair compensation to the injured and deters drivers from dangerous behavior on the road.

Stephen Chippendale counters this claim with the argument that tort-law based insurance combines high cost and low benefits, and that those who truly profit from it are the lawyers representing injured clients, while their claims clog up the court system. A better solution, he proposes, would be "Auto Choice," a plan under which consumers would choose whether or not they wished to be eligible for damages from pain and suffering.

With civility and respect, these two legal scholars present thoughtful and thorough arguments on both sides of the debate, giving readers a balanced view of an issue that affects nearly every American. It will be of particular value to those in the fields of law, policy, and insurance.

Poems that acknowledge the existential anxieties of our age while continuing to celebrate the beauty and musicality of language. 
 
In Would We Still Be, James Henry Knippen crafts the anxieties that emanate from human existence—grief, fear, hopelessness, uncertainty—into poetic reflections that express a deep reverence for the musicality and incantational capacity of language. Like a moon or a wren, two of the book’s obsessions, these haunting poems call us to consider beauty’s connection to the transitory. Among the ghosts that wander these pages—those of loved ones, those we are, and those we will become—Knippen asks if image is enough, if sound is enough, if faith is enough. In doing so, these poems seek out the soul’s communion with voice, encouraging us to sing our fate.