Taking as his point of departure Norbert Weiner’s statement that information is basic to understanding materialism in our era, Ronald Schleifer shows how discoveries of modern physics have altered conceptions of matter and energy and the ways in which both information theory and the study of literature can enrich these conceptions. Expanding the reductive notion of “the material” as simply matter and energy, he formulates a new, more inclusive idea of materialism.
Schleifer’s project attempts to bridge the divisions between the humanities and the sciences and to create a nonreductive materialism for the information age. He presents a materialistic account of human bodily experience by delving into language and literature that powerfully represents our faces, voices, hands, and pain. For example, he examines the material resources of poetic “literariness” as it is revealed in the condition of Tourette’s syndrome. Schleifer also investigates gestures of the hand in the formation of sociality, and he studies pain as both a physiological and phenomenological experience.
This ambitious work explores physiological analyses, evolutionary explanations, and semiotic descriptions of materialism to reveal how aspects of physical existence discover meaning in experience.
Geneticists and biochemists, particularly, have realized the special potentialities of antibodies as biologically labeled proteins that help to throw light on the process whereby genetic information carried in the chromosomes is eventually manifested in the synthesis of the proteins needed for the functioning of the organism. There are in addition many specialized applications of immunology in the other biological sciences.
F. M. Burnet describes with characteristic vividness the kinds of problems with which immunology is concerned today and the methods by which it seeks answers to them. Although he gives particular emphasis to the clonal-selection theory of immunity, of which he is the originator, he frankly says that “because it is so inherently simple, it is probably wrong.” He explains other theories of immunity as well. He discusses both nonmedical and medical applications of immunology and devotes several chapters to allergic disease and autoimmune disease. He concludes with some personal speculations into the deeper problems of biology—for instance, a somatic mutation theory of aging, in which immunology may be expected eventually to be of service.
In 1913, the Peter Bent Brigham Hospital in Boston admitted its first patient, Mary Agnes Turner, who suffered from varicose veins in her legs. The surgical treatment she received, under ether anesthesia, was the most advanced available at the time. At the same hospital fifty years later, Nicholas Tilney—then a second-year resident—assisted in the repair of a large aortic aneurysm. The cutting-edge diagnostic tools he used to evaluate the patient’s condition would soon be eclipsed by yet more sophisticated apparatus, including minimally invasive approaches and state-of-the-art imaging technology, which Tilney would draw on in pioneering organ transplant surgery and becoming one of its most distinguished practitioners.
In Invasion of the Body, Tilney tells the story of modern surgery and the revolutions that have transformed the field: anesthesia, prevention of infection, professional standards of competency, pharmaceutical advances, and the present turmoil in medical education and health care reform. Tilney uses as his stage the famous Boston teaching hospital where he completed his residency and went on to practice (now called Brigham and Women's). His cast of characters includes clinicians, support staff, trainees, patients, families, and various applied scientists who push the revolutions forward.
While lauding the innovations that have brought surgeons' capabilities to heights undreamed of even a few decades ago, Tilney also previews a challenging future, as new capacities to prolong life and restore health run headlong into unsustainable costs. The authoritative voice he brings to the ancient tradition of surgical invasion will be welcomed by patients, practitioners, and policymakers alike.
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