Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer’s occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body’s tissues. His theory ties cancer’s progression, or lack thereof, to evolved strategies to maximize reproductive success.

Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes—but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells’ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species’ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells.

DeGregori’s perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues’ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

This synthesis of thirty-five years of intensive investigation comes at a particularly propitious moment. Since the Second World War, cell biology and molecular biology have worked separately in probing the central question of cancer research--how do cells divide?--biology focusing on cell behavior in isolation and as part of tissues and organs, molecular biology concentrating on individual biochemical steps, especially as controlled by genes. But now a new alliance is being forged in the continuing effort to conquer cancer. New discoveries point to the value of an interdisciplinary approach, and for the first time scientists from both camps are struggling to catch up on one another's literature.

Baserga's work provides the unifying background for this cross-fertilization of ideas. It begins with the growth of cell populations and how cells interact with each other. The second section goes within the cell to consider the effect of drugs, the use of temperature-sensitive mutants of the cell cycle, and the use of cell fusion to understand how cells divide. The third section turns to the molecular genetics of cell proliferation, the growth factors, and the genes and gene products that regulate cell division.

Drawing on more than five hundred classic and recent references, the book is comprehensive yet refreshingly readable. It will provide a congenial and sophisticated introduction for students as well as working scientists.

Whether classified as regulators of inflammation, metabolism, or other physiological functions, a distinctive set of molecules enables the human body to convey information from one cell to another. An in-depth primer on the molecular mediators that coordinate complex bodily processes, Body Messages provides fresh insight into how biologists first identified this special class of molecules and the consequences of their discovery for modern medicine.

Focusing on proteins that regulate inflammation and metabolism—including the cytokines and adipokines at the core of her own research—Giamila Fantuzzi examines the role body messages play in the physiology of health as well as in the pathology of various illnesses. Readers are introduced to different ways of conceptualizing biomedical research and to the advantages and pitfalls associated with identifying molecules beginning with function or structure. By bringing together areas of research usually studied separately, Fantuzzi stresses the importance of investigating the body as a whole and affirms the futility of trying to separate basic from clinical research. Drawing on firsthand interviews with researchers who made major contributions to the field, Body Messages illustrates that the paths leading to scientific discovery are rarely direct, nor are they always the only routes available.

An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

Rather than treat cancer by aggressively trying to eliminate all cancerous cells—with harmful side effects for patients—CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells—the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation.

To date, researchers have not agreed on the defining feature of CSCs—their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell’s relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

Psychoanalyst, political theorist, pioneer of body therapies, prophet of the sexual revolution—all fitting titles, but Wilhelm Reich has never been recognized as a serious laboratory scientist, despite his experimentation with bioelectricity and unicellular organisms. Wilhelm Reich, Biologist is an eye-opening reappraisal of one of twentieth-century science’s most controversial figures—perhaps the only writer whose scientific works were burned by both the Nazis and the U.S. government. Refuting allegations of “pseudoscience” that have long dogged Reich’s research, James Strick argues that Reich’s lab experiments in the mid-1930s represented the cutting edge of light microscopy and time-lapse micro-cinematography and deserve to be taken seriously as legitimate scientific contributions.

Trained in medicine and a student of Sigmund Freud, Reich took to the laboratory to determine if Freud’s concept of libido was quantitatively measurable. His electrophysiological experiments led to his “discovery” of microscopic vesicles (he called them “bions”), which Reich hypothesized were instrumental in originating life from nonliving matter. Studying Reich’s laboratory notes from recently opened archives, Strick presents a detailed account of the bion experiments, tracing how Reich eventually concluded he had discovered an unknown type of biological radiation he called “orgone.” The bion experiments were foundational to Reich’s theory of cancer and later investigations of orgone energy.

Reich’s experimental findings and interpretations were considered discredited, but not because of shoddy lab technique, as has often been claimed. Scientific opposition to Reich’s experiments, Strick contends, grew out of resistance to his unorthodox sexual theories and his Marxist political leanings.