Cloning was first published in 1985. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.
Cloning has become in recent years a subject of widespread speculation: the word is a source of fear and wonder, the concept a jumping-off point for the fantasies of cartoonists, film producers, and novelists. With this book, cell biologist Robert Gilmore McKinnell provides the first clear scientific explanation of the procedure for general readers.
Cloning is best defined as the asexual reproduction of genetic duplicates. The word clone derives from the Greek word for a twig or a slip, and the first "cloners" were in fact horticulturalists. Early attempts to clone animals culminated in 1952 when biologists reported that they had produced frogs by transplanting genetic material from an embryonic body cell into an egg from which the nucleus had been removed.
In this account, McKinnell traces the historical background of cloning and describes in detail the modern procedure used in the cloning of frogs—the highest animal thus far cloned. He emphasizes that the purpose of cloning is not to produce numerous frogs—or people—but rather to serve as a tool in biological research—to achieve greater understanding of cancer and aging, immunobiology and the differentiation of cells.
McKinnell also deals with questions about potential mammalian clones and examines the social, ethical, and biological problems we face in our considerations about human cloning. He concludes that human clones are not necessary for research purposes and that the diversity achieved with sexual reproduction is far more desirable than the sameness of cloned creatures.
Ever since Dolly, the Scottish lamb, tottered on wobbly legs into our consciousness-followed swiftly by other animals: first, mice; then pigs that may provide human transplants, and even an ordinary house cat-thoughts have flown to the cloning of human beings. Legislators rushed to propose a ban on a technique that remains highly hypothetical, although some independent researchers have announced their determination to pursue the possibilities. Political scientist and well-known expert on reproductive issues, Andrea L. Bonnicksen examines the political reaction to this new-born science and the efforts to construct cloning policy. She also looks at issues that relate to stem cell research, its even newer sibling, and poses a key question:
How does the response to Dolly guide us as we manage innovative reproductive technologies in the future?
Various legislative endeavors and the efforts by the Food and Drug Administration (FDA) to oversee cloning, as well as policy models related to federal funding, individual state laws, and programs abroad, inform Bonnicksen's identification of four types of cloning policy. She analyzes in depth the roles of diverse interest groups as each struggle to become the dominant voice in the decision-making process. With skill and insight, she clears the mists from a complicated topic, and addresses the legal, political, and ethical arguments that are not likely to disappear from the national conversation or debates any time soon.
Franklin combines wide-ranging sources—from historical accounts of sheep-breeding, to scientific representations of cloning by nuclear transfer, to popular media reports of Dolly's creation and birth—as she draws on gender and kinship theory as well as postcolonial and science studies. She argues that there is an urgent need for more nuanced responses to the complex intersections between the social and the biological, intersections which are literally reshaping reproduction and genealogy. In Dolly Mixtures, Franklin uses the renowned sheep as an opportunity to begin developing a critical language to identify and evaluate the reproductive possibilities that post-Dolly biology now faces, and to look back at some of the important historical formations that enabled and prefigured Dollys creation.
Long before scientists at the Roslin Institute in Scotland cloned Dolly the sheep in 1996, American embryologist and aspiring cancer researcher Robert Briggs successfully developed the technique of nuclear transplantation using frogs in 1952. Although the history of cloning is often associated with contemporary ethical controversies, Forgotten Clones revisits the influential work of scientists like Briggs, Thomas King, and Marie DiBerardino, before the possibility of human cloning and its ethical implications first registered as a concern in public consciousness, and when many thought the very idea of cloning was experimentally impossible. By focusing instead on new laboratory techniques and practices and their place in Anglo-American science and society in the mid-twentieth century, Nathan Crowe demonstrates how embryos constructed in the lab were only later reconstructed as ethical problems in the 1960s and 1970s with the emergence of what was then referred to as the Biological Revolution. His book illuminates the importance of the early history of cloning for the biosciences and their institutional, disciplinary, and intellectual contexts, as well as providing new insights into the changing cultural perceptions of the biological sciences after Second World War.
Saving lives versus taking lives: These are the stark terms in which the public regards human embryo research--a battleground of extremes, a war between science and ethics. Such a simplistic dichotomy, encouraged by vociferous opponents of abortion and proponents of medical research, is precisely what Jane Maienschein seeks to counter with this book. Whose View of Life? brings the current debates into sharper focus by examining developments in stem cell research, cloning, and embryology in historical and philosophical context and by exploring legal, social, and ethical issues at the heart of what has become a political controversy.
Drawing on her experience as a researcher, teacher, and congressional fellow, Jane Maienschein provides historical and contemporary analysis to aid understanding of the scientific and social forces that got us where we are today. For example, she explains the long-established traditions behind conflicting views of how life begins--at conception or gradually, in the course of development. She prepares us to engage a major question of our day: How are we, as a 21st-century democratic society, to navigate a course that is at the same time respectful of the range of competing views of life, built on the strongest possible basis of scientific knowledge, and still able to respond to the momentous opportunities and challenges presented to us by modern biology? Maienschein's multidisciplinary perspective will provide a starting point for further attempts to answer this question.
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