Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.

Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.

By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

With the publication in 1996 of The Harvard Guide to Women's Health, women seeking answers to questions about their health had access to the combined expertise of physicians from three of the world's most prestigious medical institutions: Harvard Medical School, Massachusetts General Hospital, and Brigham and Women's Hospital. With complete information on women's health concerns, physical and behavioral, this A to Z reference quickly became a definitive resource, praised especially for its coverage of topics not previously considered under the umbrella of women's health. The New Harvard Guide to Women's Health reunites the authors to bring a valued health reference up to date for a new generation--and for those women who have come to rely on the Harvard Guide and are now wondering what to do about their health as they enter a new stage of life, asking questions like the following: I've been on hormone replacement therapy. Should I stop? How?
Could this rash be lupus?
I've been on the Pill. What is my risk for stroke?
Fat is bad, fat is good: What should I believe? And what's left to eat?
When does ordinary worry become chronic anxiety?
What screening tests do I need now?
In addition to revised recommendations reflecting the current medical thinking on menopause and hormone replacement therapy, the New Harvard Guide includes updated recommendations about cardiac health and heart disease--the #1 killer of women in the United States
entries reflecting recent advances in the understanding and treatment of autoimmune diseases
better coverage of health concerns throughout a woman's life span, from her first period to menopause and beyond, with a new entry on perimenopause
expanded nutritional recommendations, including a unique chart of the U.S. government's Daily Reference Intakes for micronutrients, broken down for teens and women whose needs may differ because they are pregnant, breastfeeding, or postmenopausal
updated information on over-the-counter medications, prescription drugs, procedures, screenings, and diagnostic tests