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August Weismann
Development, Heredity, and Evolution
Frederick B. Churchill
Harvard University Press, 2015

The evolutionist Ernst Mayr considered August Weismann “one of the great biologists of all time.” Yet the man who formulated the germ plasm theory—that inheritance is transmitted solely through the nuclei of the egg and sperm cells—has not received an in-depth historical examination. August Weismann reintroduces readers to a towering figure in the life sciences. In this first full-length biography, Frederick Churchill situates Weismann in the swirling intellectual currents of his era and demonstrates how his work paved the way for the modern synthesis of genetics and evolution in the twentieth century.

In 1859 Darwin’s tantalizing new idea stirred up a great deal of activity and turmoil in the scientific world, to a large extent because the underlying biological mechanisms of evolution through natural selection had not yet been worked out. Weismann’s achievement was to unite natural history, embryology, and cell biology under the capacious dome of evolutionary theory. In his major work on the germ plasm (1892), which established the material basis of heredity in the “germ cells,” Weismann delivered a crushing blow to Lamarck’s concept of the inheritance of acquired traits.

In this deeply researched biography, Churchill explains the development of Weismann’s pioneering work based on cytology and embryology and opens up an expanded history of biology from 1859 to 1914. August Weismann is sure to become the definitive account of an extraordinary life and career.

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A Cultural History of Heredity
Staffan Müller-Wille and Hans-Jörg Rheinberger
University of Chicago Press, 2012

It was only around 1800 that heredity began to enter debates among physicians, breeders, and naturalists. Soon thereafter it evolved into one of the most fundamental concepts of biology. Here Staffan Müller-Wille and Hans-Jörg Rheinberger offer a succinct cultural history of the scientific concept of heredity. They outline the dramatic changes the idea has undergone since the early modern period and describe the political and technological developments that brought about these changes.

Müller-Wille and Rheinberger begin with an account of premodern theories of generation, showing that these were concerned with the procreation of individuals rather than with hereditary transmission. The authors reveal that when hereditarian thinking first emerged, it did so in a variety of cultural domains, such as politics and law, medicine, natural history, breeding, and anthropology. Müller-Wille and Rheinberger then track theories of heredity from the late nineteenth century—when leading biologists considered it in light of growing societal concerns with race and eugenics—through the rise of classical and molecular genetics in the twentieth century, to today, as researchers apply sophisticated information technologies to understand heredity. What readers come to see from this exquisite history is why it took such a long time for heredity to become a prominent concept in the life sciences and why it gained such overwhelming importance in those sciences and the broader culture over the last two centuries.

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A Guinea Pig’s History of Biology
Jim Endersby
Harvard University Press, 2007

"Endless forms most beautiful and most wonderful have been, and are being, evolved," Darwin famously concluded The Origin of Species, and for confirmation we look to...the guinea pig? How this curious creature and others as humble (and as fast-breeding) have helped unlock the mystery of inheritance is the unlikely story Jim Endersby tells in this book.

Biology today promises everything from better foods or cures for common diseases to the alarming prospect of redesigning life itself. Looking at the organisms that have made all this possible gives us a new way of understanding how we got here--and perhaps of thinking about where we're going. Instead of a history of which great scientists had which great ideas, this story of passionflowers and hawkweeds, of zebra fish and viruses, offers a bird's (or rodent's) eye view of the work that makes science possible.

Mixing the celebrities of genetics, like the fruit fly, with forgotten players such as the evening primrose, the book follows the unfolding history of biological inheritance from Aristotle's search for the "universal, absolute truth of fishiness" to the apparently absurd speculations of eighteenth-century natural philosophers to the spectacular findings of our day--which may prove to be the absurdities of tomorrow.

The result is a quirky, enlightening, and thoroughly engaging perspective on the history of heredity and genetics, tracing the slow, uncertain path--complete with entertaining diversions and dead ends--that led us from the ancient world's understanding of inheritance to modern genetics.

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Heredity and Hope
The Case for Genetic Screening
Ruth Schwartz Cowan
Harvard University Press, 2008

The secrets locked in our genes are being revealed, and we find ourselves both enthused and frightened about what that portends. We look forward to curing disease and alleviating suffering—for our children as well as for ourselves—but we also worry about delving too deeply into the double helix. Abuses perpetrated by eugenicists—from involuntary sterilization to murder—continue to taint our feelings about genetic screening.

Yet, as Ruth Schwartz Cowan reveals, modern genetic screening has been practiced since 1960, benefiting millions of women and children all over the world. She persuasively argues that new forms of screening—prenatal, newborn, and carrier testing—are both morally right and politically acceptable. Medical genetics, built on the desire of parents and physicians to reduce suffering and increase personal freedom, not on the desire to “improve the human race,” is in fact an entirely different enterprise from eugenics.

Cowan’s narrative moves from an account of the interwoven histories of genetics and eugenics in the first half of the twentieth century, to the development of new forms of genetic screening after mid-century. It includes illuminating chapters on the often misunderstood testing programs for sickle cell anemia, and on the world’s only mandated premarital screening programs, both of them on the island of Cyprus.

Neither minimizing the difficulty of the choices that modern genetics has created for us nor fearing them, Cowan bravely and compassionately argues that we can improve the quality of our own lives and the lives of our children by using the modern science and technology of genetic screening responsibly.

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Heredity, Environment, and Personality
A Study of 850 Sets of Twins
By John C. Loehlin and Robert C. Nichols
University of Texas Press, 1976

This volume reports on a study of 850 pairs of twins who were tested to determine the influence of heredity and environment on individual differences in personality, ability, and interests. It presents the background, research design, and procedures of the study, a complete tabulation of the test results, and the authors’ extensive analysis of their findings. Based on one of the largest studies of twin behavior conducted in the twentieth century, the book challenges a number of traditional beliefs about genetic and environmental contributions to personality development.

The subjects were chosen from participants in the National Merit Scholarship Qualifying Test of 1962 and were mailed a battery of personality and interest questionnaires. In addition, parents of the twins were sent questionnaires asking about the twins’ early experiences. A similar sample of nontwin students who had taken the merit exam provided a comparison group. The questions investigated included how twins are similar to or different from nontwins, how identical twins are similar to or different from fraternal twins, how the personalities and interests of twins reflect genetic factors, how the personalities and interests of twins reflect early environmental factors, and what implications these questions have for the general issue of how heredity and environment influence the development of psychological characteristics. In attempting to answer these questions, the authors shed light on the importance of both genes and environment and form the basis for different approaches in behavior genetic research.

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Hormones, Heredity, and Race
Spectacular Failure in Interwar Vienna
Cheryl A. Logan
Rutgers University Press, 2013
Early in the twentieth century, arguments about “nature” and “nurture” pitted a rigid genetic determinism against the idea that genes were flexible and open to environmental change. This book tells the story of three Viennese biologists—Paul Kammerer, Julius Tandler, and Eugen Steinach—who sought to show how the environment could shape heredity through the impact of hormones. It also explores the dynamic of failure through both scientific and social lenses. During World War I, the three men were well respected scientists; by 1934, one was dead by his own hand, another was in exile, and the third was subject to ridicule.

Paul Kammerer had spent years gathering  zoological evidence on whether environmental change could alter heredity, using his research as the scientific foundation for a new kind of eugenics—one that challenged the racism growing in mainstream eugenics. By 1918, he drew on the pioneering research of two colleagues who studied how secretions shaped sexual attributes to argue that hormones could alter genes. After 1920, Julius Tandler employed a similar concept to restore the health and well-being of Vienna's war-weary citizens. Both men rejected the rigidly acting genes of the new genetics and instead crafted a biology of flexible heredity to justify eugenic reforms that respected human rights. But the interplay of science and personality with the social and political rise of fascism and with antisemitism undermined their ideas, leading to their spectacular failure.
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Mixed Messages
Cultural and Genetic Inheritance in the Constitution of Human Society
Robert A. Paul
University of Chicago Press, 2015
As social and symbolic animals—animals with language and systems of signs—humans are informed by two different kinds of heritage, one biological, the other cultural. Scholars have tended to study our genetic and symbolic lineages separately, but in recent years some have begun to explore them together, offering a “dual inheritance theory.” In this book, Robert A. Paul offers an entirely new and original consideration of our dual inheritance to date, going deep inside an extensive ethnographic record to outline a fascinating relationship between our genetic codes and symbolic systems.
           
Examining a wide array of cultures, Paul reveals how the inherent tensions between these two modes of transmission generate many of the features of human society, such as marriage rules, initiation rituals, gender asymmetry, and sexual symbolism. Exploring differences in the requirements, range, and agendas of genetic and symbolic reproduction, he shows that a properly conceived dual inheritance model does a better job of accounting for the distinctive character of actual human societies than either evolutionary or socio-cultural construction theories can do alone. Ultimately this book offers a powerful call for a synthesis of the traditions inspired by Darwin, Durkheim, and Freud—one that is critically necessary if we are to advance our understanding of human social life.
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