A daily glass of wine prolongs life—yet alcohol can cause life-threatening cancer. Some say raising the minimum wage will decrease inequality while others say it increases unemployment. Scientists once confidently claimed that hormone replacement therapy reduced the risk of heart disease but now they equally confidently claim it raises that risk. What should we make of this endless barrage of conflicting claims?
Observation and Experiment is an introduction to causal inference by one of the field’s leading scholars. An award-winning professor at Wharton, Paul Rosenbaum explains key concepts and methods through lively examples that make abstract principles accessible. He draws his examples from clinical medicine, economics, public health, epidemiology, clinical psychology, and psychiatry to explain how randomized control trials are conceived and designed, how they differ from observational studies, and what techniques are available to mitigate their bias.
“Carefully and precisely written…reflecting superb statistical understanding, all communicated with the skill of a master teacher.”
—Stephen M. Stigler, author of The Seven Pillars of Statistical Wisdom
“An excellent introduction…Well-written and thoughtful…from one of causal inference’s noted experts.”
—Journal of the American Statistical Association
“Rosenbaum is a gifted expositor…an outstanding introduction to the topic for anyone who is interested in understanding the basic ideas and approaches to causal inference.”
—Psychometrika
“A very valuable contribution…Highly recommended.”
—International Statistical Review
We live in an age of obsession. Not only are we hopelessly devoted to our work, strangely addicted to our favorite television shows, and desperately impassioned about our cars, we admire obsession in others: we demand that lovers be infatuated with one another in films, we respond to the passion of single-minded musicians, we cheer on driven athletes. To be obsessive is to be American; to be obsessive is to be modern.
But obsession is not only a phenomenon of modern existence: it is a medical category—both a pathology and a goal. Behind this paradox lies a fascinating history, which Lennard J. Davis tells in Obsession. Beginning with the roots of the disease in demonic possession and its secular successors, Davis traces the evolution of obsessive behavior from a social and religious fact of life into a medical and psychiatric problem. From obsessive aspects of professional specialization to obsessive compulsive disorder and nymphomania, no variety of obsession eludes Davis’s graceful analysis.
Responding to the growing need for tried-and-trusted solutions to the reproductive health care issues confronting millions of women worldwide, Obstetrics and Gynecology in Low-Resource Settings provides practical guidelines for ensuring the delivery of quality OB/GYN care to women in resource-poor countries. Including contributions from leading clinicians and researchers in the field, this welcome overview fills an important gap in existing medical literature on women’s health care and will be an invaluable resource for doctors, clinicians, and medical students at all stages of their careers who work in the global health arena.
The reproductive health risks that all women face are greatly exacerbated when health care facilities are inadequate, equipment and medications are in short supply, and well-trained medical staff are few and far away. Often in these settings, the sole doctor or medical professional on hand has expertise in some areas of women’s reproductive care but needs a refresher course in others.
This informative guide features hands-on, step-by-step instruction for the most pertinent OB/GYN conditions—both acute and chronic—that health care workers in the field confront. The authors examine a wide range of topics, including: strategies to reduce maternal mortality and stillbirths; infectious and sexually transmitted diseases, including malaria and HIV; cervical cancer; contraception; prenatal, delivery, and newborn care; and complications arising from gender-based violence and female genital cutting. Published in a convenient format with a durable binding, this reference will be an essential companion to health care providers throughout the world.
Psychoanalysis, entering its second century, is a vital yet divided discipline. A confusing array of mutually contradictory theories compete for the loyalty of clinicians and for the attention of all those interested in understanding human experience.
In the classic Object Relations in Psychoanalytic Theory, Jay Greenberg and his coauthor Stephen Mitchell brought clarity to the confusion surrounding psychoanalytic disputes. They defined two competing models: the drive model, which addresses the private dimensions of experience; and the relational model, which reveals the relentlessly social aspect of our lives. Oedipus and Beyond builds on Greenberg’s earlier contribution. Beginning with a brilliant critique of the conceptual framework of psychoanalysis, he provides fresh insight into Freud’s theory, demonstrating how attempts to resolve some of its shortcomings have generated their own theoretical and clinical dilemmas. In the process he illuminates the roles of the Oedipus complex, the drives, the unconscious, and psychic structure in shaping the sensibilities of alternative psychoanalytic approaches.
Greenberg does not attempt to synthesize the two models, because he believes that diversity is essential if psychoanalysis is to remain strong. Instead, he proposes a compelling and practical clinical theory in which Freud’s insistence on the importance of inner motivation, psychic conflict, and personal agency effectively informs a relational emphasis on the fundamental influence of social living.
The book concludes with some apt illustrations of how the “representational model” can enrich clinical work. Greenberg rethinks the process of making the unconscious conscious, and arrives at new approaches to the analyst’s neutrality, to transference analysis, and to countertransference. The result reflects the author’s profound insight into the structure of psychoanalytic theory and his mastery of the contributions of diverse psychoanalytic schools. Perhaps most important, Greenberg’s argument never loses touch with his clinical experience; ultimately, this is the deeply personal statement of a skilled practitioner.
In the early twentieth century lead had many domestic uses: in solder for cans, as a gasoline additive to prevent “knocking” in engines, in water pipes, and, most prominently, in interior paint prized for its durability and ability to hold color. Far from being the toxic hazard we recognize today, lead was a valuable commodity. However, by the end of the century, lead had largely disappeared from our environment as physicians discovered the threat it posed to children’s health and mental development.
Old Paint documents the history of lead-paint poisoning in the United States and the evolving responses of public health officials and the lead-paint industry to this hazard up to 1980, by which time lead had been banned from gasoline and paint. Peter C. English traces lead poisoning from a rare, but acute problem confined to a small group of children to the discovery by the end of the 1940s of the dangers of the crumbling lead-painted interiors of inner-city dwellings. He draws on a wide range of primary materials not only to illuminate our understanding of how this health hazard changed over time, but also to explore how diseases are constructed and evolve.
A Roman layman’s account of medicine in his time.
A. Cornelius Celsus was author, probably during the reign of the Roman Emperor Tiberius (AD 14–37), of a general encyclopedia of agriculture, medicine, military arts, rhetoric, philosophy, and jurisprudence, in that order of subjects. Of all this great work there survives only the eight books on medicine (De Medicina).
In Book I, after an excellent survey of Greek schools (Dogmatic, Methodic, Empiric) of medicine come sensible dietetics that will always be applicable. Book II deals with prognosis, diagnosis of symptoms (which he stresses strongly), and general therapeutics. Book III addresses internal ailments, fevers, and general diseases. Book IV treats local bodily diseases. Next come two pharmacological books, Book V on treatment by drugs of general diseases, and Book VI on local diseases. Books VII and VIII deal with surgery; these books contain accounts of many operations, including amputation.
Celsus was not a professional doctor of medicine or a surgeon, but a practical layman whose On Medicine, written in a clear and neat style for lay readers, is partly a result of his medical treatment of his household (slaves included), and partly a presentation of information gained from many Greek authorities. From no other source can we learn so much of the condition of medical science up to his own time.
The Loeb Classical Library edition of Celsus is in three volumes.
A Roman layman’s account of medicine in his time.
A. Cornelius Celsus was author, probably during the reign of the Roman Emperor Tiberius (AD 14–37), of a general encyclopedia of agriculture, medicine, military arts, rhetoric, philosophy, and jurisprudence, in that order of subjects. Of all this great work there survives only the eight books on medicine (De Medicina).
In Book I, after an excellent survey of Greek schools (Dogmatic, Methodic, Empiric) of medicine come sensible dietetics that will always be applicable. Book II deals with prognosis, diagnosis of symptoms (which he stresses strongly), and general therapeutics. Book III addresses internal ailments, fevers, and general diseases. Book IV treats local bodily diseases. Next come two pharmacological books, Book V on treatment by drugs of general diseases, and Book VI on local diseases. Books VII and VIII deal with surgery; these books contain accounts of many operations, including amputation.
Celsus was not a professional doctor of medicine or a surgeon, but a practical layman whose On Medicine, written in a clear and neat style for lay readers, is partly a result of his medical treatment of his household (slaves included), and partly a presentation of information gained from many Greek authorities. From no other source can we learn so much of the condition of medical science up to his own time.
The Loeb Classical Library edition of Celsus is in three volumes.
A Roman layman’s account of medicine in his time.
A. Cornelius Celsus was author, probably during the reign of the Roman Emperor Tiberius (AD 14–37), of a general encyclopedia of agriculture, medicine, military arts, rhetoric, philosophy, and jurisprudence, in that order of subjects. Of all this great work there survives only the eight books on medicine (De Medicina).
In Book I, after an excellent survey of Greek schools (Dogmatic, Methodic, Empiric) of medicine come sensible dietetics that will always be applicable. Book II deals with prognosis, diagnosis of symptoms (which he stresses strongly), and general therapeutics. Book III addresses internal ailments, fevers, and general diseases. Book IV treats local bodily diseases. Next come two pharmacological books, Book V on treatment by drugs of general diseases, and Book VI on local diseases. Books VII and VIII deal with surgery; these books contain accounts of many operations, including amputation.
Celsus was not a professional doctor of medicine or a surgeon, but a practical layman whose On Medicine, written in a clear and neat style for lay readers, is partly a result of his medical treatment of his household (slaves included), and partly a presentation of information gained from many Greek authorities. From no other source can we learn so much of the condition of medical science up to his own time.
The Loeb Classical Library edition of Celsus is in three volumes.
Antiquity’s most prolific and influential medical writer and practitioner.
Galen of Pergamum (129–?199/216), physician to the court of the emperor Marcus Aurelius, was a philosopher, scientist, medical historian, theoretician, and practitioner who wrote forcefully and prolifically on an astonishing range of subjects and whose impact on later eras rivaled that of Aristotle. Galen synthesized the entirety of Greek medicine as a basis for his own doctrines and practice, which comprehensively embraced theory, practical knowledge, experiment, logic, and a deep understanding of human life and society.
This volume presents three works of the greatest importance to Galen’s theory and practice of medicine. On Temperaments sets out Galen’s concept of the combination (krasis) of the four elemental qualities (hot, cold, wet, and dry), which is fundamental to his account of the structure and function of the human body and of animal and plant bodies generally, and is in turn essential to his theory of medical practice. The two related works, On Non-Uniform Distemperment and The Soul’s Traits Depend on Bodily Temperament, deal with specific aspects of dyskrasia, which is a disturbance in the combination of these qualities. Appended are two related short treatises, On the Best Constitution of Our Body and On Good Bodily State.
Antiquity’s most prolific and influential medical writer and practitioner.
Galen of Pergamum (129–?199/216), physician to the court of the emperor Marcus Aurelius, was a philosopher, scientist, and medical historian, a theoretician and practitioner, who wrote forcefully and prolifically on an astonishing range of subjects and whose impact on later eras rivaled that of Aristotle. Galen synthesized the entirety of Greek medicine as a basis for his own doctrines and practice, which comprehensively embraced theory, practical knowledge, experiment, logic, and a deep understanding of human life and society.
In the three classic works in this volume, On the Constitution of the Art of Medicine, The Art of Medicine, and A Method of Medicine to Glaucon, Galen covers fundamental aspects of his practice in a lucid and engaging style designed to appeal to a broad audience.
Antiquity’s most prolific and influential medical writer and practitioner.
If the work of Hippocrates is taken as representing the foundation upon which the edifice of historical Greek medicine was raised, then the work of Galen, who lived some six hundred years later, may be looked upon as the summit of the same edifice.
He was born in Pergamum AD 129, and both there and in other academic centers of the Aegean pursued his medical studies before being appointed physician to the Pergamene gladiators in 157. Becoming dissatisfied with this type of practice he emigrated to Rome, where he soon won acknowledgement as the foremost medical authority of his time and where, with one brief interruption, he remained until his death in 199.
Galen’s merit is to have crystallized or brought into focus all the best work of the Greek medical schools which had preceded his own time. It is essentially in the form of Galenism that Greek medicine was transmitted to after ages.
Peripatetic works on the human body and soul.
Aristotle, great Greek philosopher, researcher, reasoner, and writer, born at Stagirus in 384 BC, was the son of a physician. He studied under Plato at Athens and taught there (367–347); subsequently he spent three years at the court of a former pupil in Asia Minor. After some time at Mitylene, in 343–342 he was appointed by King Philip of Macedon to be tutor of his teen-aged son Alexander. After Philip’s death in 336, Aristotle became head of his own school (of “Peripatetics”), the Lyceum at Athens. Because of anti-Macedonian feeling there after Alexander’s death in 323, he withdrew to Chalcis in Euboea, where he died in 322.
Nearly all the works Aristotle prepared for publication are lost; the priceless ones extant are lecture-materials, notes, and memoranda (some are spurious). They can be categorized as follows:
I Practical: Nicomachean Ethics; Great Ethics (Magna Moralia); Eudemian Ethics; Politics; Economics (on the good of the family); On Virtues and Vices.
II Logical: Categories; Analytics (Prior and Posterior); Interpretation; Refutations used by Sophists; Topica.
III Physical: Twenty-six works (some suspect) including astronomy, generation and destruction, the senses, memory, sleep, dreams, life, facts about animals, etc.
IV Metaphysics: on being as being.
V Art: Rhetoric and Poetics.
VI Other works including the Constitution of Athens; more works also of doubtful authorship.
VII Fragments of various works such as dialogues on philosophy and literature; and of treatises on rhetoric, politics, and metaphysics.
The Loeb Classical Library® edition of Aristotle is in twenty-three volumes.
A shotgun misfires inside the American Fur Company store in Northern Michigan, and Alexis St. Martin's death appears imminent. It's 1822, and, as the leaders of Mackinac Island examine St. Martin's shot-riddled torso, they decide not to incur a single expense on behalf of the indentured fur trapper. They even go so far as to dismiss the attention of U.S. Army Assistant Surgeon William Beaumont, the frontier fort's only doctor.
Beaumont ignores the orders and saves the young man's life. What neither the doctor nor his patient understands—yet—is that even as Beaumont's care of St. Martin continues for decades, the motives and merits of his attention are far from clear. In fact, for what he does to his patient, Beaumont will eventually stand trial and be judged.
Rooted deeply in historic fact, Open Wound artfully fictionalizes the complex, lifelong relationship between Beaumont and his illiterate French Canadian patient. The young trapper's injury never completely heals, leaving a hole into his stomach that the curious doctor uses as a window to understand the mysteries of digestion. Eager to rise up from his humble origins and self-conscious that his medical training occurred as an apprentice to a rural physician rather than at an elite university, Beaumont seizes the opportunity to experiment upon his patient's stomach in order to write a book that he hopes will establish his legitimacy and secure his prosperity. As Jason Karlawish portrays him, Beaumont, always growing hungrier for more wealth and more prestige, personifies the best and worst aspects of American ambition and power.
Nearly 120,000 people are in need of healthy organs in the United States. Every ten minutes a new name is added to the list, while on average twenty people die each day waiting for an organ to become available. Worse, our traditional reliance on cadaveric organ donation is becoming increasingly insufficient, and in recent years there has been a decline in the number of living donors as well as in the percentage of living donors relative to overall kidney donors. Some transplant surgeons and policy advocates have responded to this shortage by arguing for the legalization of the sale of organs among living donors. Andrew Flescher objects to this approach by going beyond concerns traditionally cited about social justice, commodification, and patient safety, and moving squarely onto the terrain of discussing what motivates major and costly acts of human selflessness.
What is the most efficacious means of attracting prospective living kidney donors? Flescher, drawing on literature in the fields of moral psychology and economics, as well as on scores of interviews with living donors, suggests that inculcating a sense of altruism and civic duty is a more effective means of increasing donor participation than the resort to financial incentives. He encourages individuals to spend time with patients on dialysis in order to become acquainted with their plight and, as an alternative to lump-sum payments, consider innovative solutions that positively impact living donor participation that do not undermine the spirit of the National Organ Transplant Act of 1984. This book not only re-examines the important debate over whether to allow the sale of organs; it is also the first volume in the field to take a close look at alternative solutions to the organ shortage crisis.
The replacement of a diseased organ by a healthy one is a medical dream that has become a reality for thousands of men and women, boys and girls. Once considered experimental and highly risky, human tissue and organ transplantation is today's successful therapy for disorders affecting the heart, liver, kidney, pancreas, eyes, ears, and bone marrow. Combining the most advanced techniques in surgery, immunology, infectious diseases, cardiology, nephrology, psychiatry, and nursing, organ transplantation is at the forefront of medical science.
Despite the advances in transplantation, the literature available to a potential transplant recipient is scant. This book, written by members of the world-renowned transplant team at the Massachusetts General Hospital in collaboration with a veteran medical journalist, is expressly created for patients and their families, the lay public, and allied health personnel. With an unparalleled sweep, the authors present a history of human organ transplantation, a review of transplant immunology and antirejection drugs, a survey of the national donor organ network, a characterization of the hospital transplant team, and the process of harvesting donor organs. They also discuss the realities of surgery and recovery; potential complications, and hints for transplant recipients and their families on how to cope with the stresses of illness, the wait for a donor organ, and the transplant operation itself.
In providing a clear picture of what to expect from an organ transplant, the authors include case studies of patients' experiences before and following transplantation, and they depict how patients and their families interact with the hospital's medical team. As a result, this book offers a sympathetic and unsensationalized guide for the more than 20,000 patients each day who await an organ transplant-and for those who are intimately involved with the patient's successful recovery.
For thousands of years, horror of the dead, superstition, and oppressive decrees prevented our ancestors from looking inside the human body; in ancient civilizations, diagnostics were based on imagination and theory, with only limited observation. So people developed suppositions about health and disease without knowing how the liver, heart, brain, and blood vessels looked or functioned. In tracing the history of medical imaging, Doby and Alker establish that it was not until the Renaissance and the detailed drawings of human anatomy by da Vinci and Vesalius that successful internal imaging of the human body was born.
At the turn of the nineteenth century, Roentgen’s discovery of the X-ray provided the first miraculous look into the living body. From that instant, medical imaging developed at an ever-increasing pace, evolving to more recent discoveries in nuclear medicine, CT scanning, and ultrasound and magnetic resonance imaging.
As Doby and Alker note, we can expect our efforts to be understood in the future only if we examine past events with an appreciation of the difficulties and challenges that faced our predecessors. Despite almost unbelievable advances in current medical technology, we must still rely on our own resources and common sense as human beings in understanding what technology can and cannot do for us.
A comprehensive set of appendixes pictorially depicting the history of imaging round out the volume.Nearly a century has passed since Freud's theories unleashed a revolution in our understanding of the human psyche. Yet, as Arnold Modell firmly points out, we still do not possess a theory that explains how psychoanalysis works. Other Times, Other Realities provides brilliant insight into this perplexing problem and lays the foundation for a comprehensive theory of psychoanalytic treatment. Modell's careful consideration of Freudian theory, the interpretations of contemporary ego psychology, and the contribution of object theory discloses the changing significance of the fundamental elements of the therapeutic process.
In Other Times, Other Realities, readers will discover an illuminating synthesis of concepts underlying the various interpretations of the psychoanalytic process.
Our Marvelous Bodies offers a unique perspective on the structure, function, and care of the major systems of the human body. Unlike other texts that use a strictly scientific approach, physiologist Gary F. Merrill relays medical facts alongside personal stories that help students relate to and apply the information.
Readers learn the basics of feedback control systems, homeostasis, and physiological gradients. These principles apply to an understanding of the body’s functioning under optimal, healthy conditions, and they provide insight into states of acute and chronic illness. Separate chapters are devoted to each of the body’s systems in detail: nervous, endocrine, cardiovascular, respiratory, renal, gastrointestinal, musculoskeletal, reproductive, and immune. Through a series of real-life examples, the book also shows the importance of maintaining careful medical records for health care professionals, scientists, and patients alike.
A Behavioral Scientist Notable Book of the Year
A Guardian “Best Book about Ideas” of the Year
No one likes to be bored. Two leading psychologists explain what causes boredom and how to listen to what it is telling you, so you can live a more engaged life.
We avoid boredom at all costs. It makes us feel restless and agitated. Desperate for something to do, we play games on our phones, retie our shoes, or even count ceiling tiles. And if we escape it this time, eventually it will strike again. But what if we listened to boredom instead of banishing it?
Psychologists James Danckert and John Eastwood contend that boredom isn’t bad for us. It’s just that we do a bad job of heeding its guidance. When we’re bored, our minds are telling us that whatever we are doing isn’t working—we’re failing to satisfy our basic psychological need to be engaged and effective. Too many of us respond poorly. We become prone to accidents, risky activities, loneliness, and ennui, and we waste ever more time on technological distractions. But, Danckert and Eastwood argue, we can let boredom have the opposite effect, motivating the change we need. The latest research suggests that an adaptive approach to boredom will help us avoid its troubling effects and, through its reminder to become aware and involved, might lead us to live fuller lives.
Out of My Skull combines scientific findings with everyday observations to explain an experience we’d like to ignore, but from which we have a lot to learn. Boredom evolved to help us. It’s time we gave it a chance.
An award-winning genetic researcher who helped contain the Ebola outbreak and a prize-winning journalist reveal what it will take to prevent the next pandemic from spiraling out of control.
As we saw with our response to Ebola and Zika—and are seeing now with the disastrous early handling of the coronavirus COVID-19 outbreak—a lack of preparedness, delays in action, and large-scale system-wide problems with the distribution of critical medical resources can result in lost lives.
Outbreak Culture examines each phase of the 2014 Ebola outbreak in West Africa—one of the largest and deadliest epidemics to date—and identifies factors that prevented key information from reaching physicians. Drawing insights from clinical workers, data collectors, organizational experts, and public health researchers, Pardis Sabeti and Lara Salahi expose a fractured system that failed to gather and share knowledge of the virus and ensure timely containment. The authors describe how much more could have been done by global medical and political organizations to safeguard the well-being of caregivers, patients, and communities affected by this devastating outbreak and they outline changes that are urgently needed to ensure a more effective coordinated response to the next epidemic.
Secrecy, competition, and poor coordination plague nearly every major public health crisis—and we are seeing their deadly consequences play out again. A work of fearless integrity and unassailable authority, Outbreak Culture seeks to change the culture of responders.
A Choice Outstanding Academic Title of the Year
“A critical, poignant postmortem of the epidemic.”
—Washington Post
“Forceful and instructive…Sabeti and Salahi uncover competition, sabotage, fear, blame, and disorganization bordering on chaos, features that are seen in just about any lethal epidemic.”
—Paul Farmer, cofounder of Partners in Health
“The central theme of the book…is that common threads of dysfunction run through responses to epidemics…The power of Outbreak Culture is its universality.”
—Nature
“Sabeti and Salahi present a wealth of evidence supporting the imperative that outbreak response must operate in a coordinated, real-time manner.”
—Science
As we saw with the Ebola outbreak—and the disastrous early handling of the COVID-19 coronavirus pandemic—a lack of preparedness, delays, and system-wide problems with the distribution of critical medical supplies can have deadly consequences. Yet after every outbreak, the systems put in place to coordinate emergency responses are generally dismantled.
One of America’s top biomedical researchers, Dr. Pardis Sabeti, and her Pulitzer Prize–winning collaborator, Lara Salahi, argue that these problems are built into the ecosystem of our emergency responses. With an understanding of the path of disease and insight into political psychology, they show how secrecy, competition, and poor coordination plague nearly every major public health crisis and reveal how much more could be done to safeguard the well-being of caregivers, patients, and vulnerable communities. A work of fearless integrity and unassailable authority, Outbreak Culture seeks to ensure that we make some urgently needed changes before the next pandemic.
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