A SCHOLARLY BOOK REPOSITORY
With Adaptation in Metapopulations, Michael J. Wade explores a key component of this new understanding of evolution: interaction. Synthesizing decades of work in the lab and in the field in a book both empirically grounded and underpinned by a strong conceptual framework, Wade looks at the role of interaction across scales from gene selection to selection at the level of individuals, kin, and groups. In so doing, he integrates molecular and organismal biology to reveal the true complexities of evolutionary dynamics from genes to metapopulations.
Examining the racial underpinnings of food, microbial medicine, and disgust in America
American Disgust shows how perceptions of disgust and fears of contamination are rooted in the country’s history of colonialism and racism. Drawing on colonial, corporate, and medical archives, Matthew J. Wolf-Meyer argues that microbial medicine is closely entwined with changing cultural experiences of digestion, excrement, and disgust that are inextricably tied to the creation of whiteness.
Ranging from nineteenth-century colonial encounters with Native people to John Harvey Kellogg’s ideas around civilization and bowel movements to mid-twentieth-century diet and parenting advice books, Wolf-Meyer analyzes how embedded racist histories of digestion and disgust permeate contemporary debates around fecal microbial transplants and other bacteriotherapeutic treatments for gastrointestinal disease.
At its core, American Disgust wrestles with how changing cultural notions of digestion—what goes into the body and what comes out of it—create and impose racial categories motivated by feelings of disgust rooted in American settler-colonial racism. It shows how disgust is a changing, yet fundamental, aspect of American subjectivity and that engaging with it—personally, politically, and theoretically—opens up possibilities for conceptualizing health at the individual, societal, and planetary levels.
The Arts of the Microbial World explores the significance of fermentation phenomena, both as life processes and as technologies, in Japanese scientific culture. Victoria Lee’s careful study documents how Japanese scientists and skilled workers sought to use the microbe’s natural processes to create new products, from soy-sauce mold starters to MSG, vitamins to statins. In traditional brewing houses as well as in the food, fine chemical, and pharmaceutical industries across Japan, they showcased their ability to deal with the enormous sensitivity and variety of the microbial world.
Charting developments in fermentation science from the turn of the twentieth century, when Japan was an industrializing country on the periphery of the world economy, to 1980 when it had emerged as a global technological and economic power, Lee highlights the role of indigenous techniques in modern science as it took shape in Japan. In doing so, she reveals how knowledge of microbes lay at the heart of some of Japan’s most prominent technological breakthroughs in the global economy.
At a moment when twenty-first-century developments in the fields of antibiotic resistance, the microbiome, and green chemistry suggest that the traditional eradication-based approach to the microbial world is unsustainable, twentieth-century Japanese microbiology provides a new, broader vantage for understanding and managing microbial interactions with society.
In the years since the 9/11 attacks—and the subsequent lethal anthrax letters—the United States has spent billions of dollars on measures to defend the population against the threat of biological weapons. But as Lynn C. Klotz and Edward J. Sylvester argue forcefully in Breeding Bio Insecurity, all that money and effort hasn’t made us any safer—in fact, it has made us more vulnerable.
Breeding Bio Insecurity reveals the mistakes made to this point and lays out the necessary steps to set us on the path toward true biosecurity. The fundamental problem with the current approach, according to the authors, is the danger caused by the sheer size and secrecy of our biodefense effort. Thousands of scientists spread throughout hundreds of locations are now working with lethal bioweapons agents—but their inability to make their work public causes suspicion among our enemies and allies alike, even as the enormous number of laboratories greatly multiplies the inherent risk of deadly accidents or theft. Meanwhile, vital public health needs go unmet because of this new biodefense focus. True biosecurity, the authors argue, will require a multipronged effort based in an understanding of the complexity of the issue, guided by scientific ethics, and watched over by a vigilant citizenry attentive to the difference between fear mongering and true analysis of risk.
An impassioned warning that never loses sight of political and scientific reality, Breeding Bio Insecurity is a crucial first step toward meeting the evolving threats of the twenty-first century.
Microorganisms, such as bacteria, are important determinants of health at the individual, ecosystem, and global levels. And yet many aspects of modern life, from the overuse of antibiotics to chemical spills and climate change, can have devastating, lasting impacts on the communities formed by microorganisms. Drawing on the latest scientific research and real-life examples such as attempts to reengineer these communities through microbial transplantation, the construction of synthetic communities of microorganisms, and the use of probiotics, this book explores how and why communities of microorganisms respond to disturbance, and what might lead to failure. It also unpacks related and interwoven philosophical questions: What is an organism? Can a community evolve by natural selection? How can we make sense of function and purpose in the natural world? How should we think about regeneration as a phenomenon that occurs at multiple biological scales? Provocative and nuanced, this primer offers an accessible conceptual and theoretical understanding of regeneration and evolution at the community level that will be essential across disciplines including philosophy of biology, conservation biology, microbiomics, medicine, evolutionary biology, and ecology.
A Contagious Cause is the first book to trace the century-long hunt for a human cancer virus in America, an effort whose scale exceeded that of the Human Genome Project. The government’s campaign merged the worlds of molecular biology, public health, and military planning in the name of translating laboratory discoveries into useful medical therapies. However, its expansion into biomedical research sparked fierce conflict. Many biologists dismissed the suggestion that research should be planned and the idea of curing cancer by a vaccine or any other means as unrealistic, if not dangerous. Although the American hunt was ultimately fruitless, this effort nonetheless profoundly shaped our understanding of life at its most fundamental levels. A Contagious Cause links laboratory and legislature as has rarely been done before, creating a new chapter in the histories of science and American politics.
The threat of biological weapons has never attracted as much public attention as in the past five years. Current concerns largely relate to the threat of weapons acquisition and use by rogue states or by terrorists. But the threat has deeper roots—it has been evident for fifty years that biological agents could be used to cause mass casualties and large-scale economic damage. Yet there has been little historical analysis of such weapons over the past half-century.
Deadly Cultures sets out to fill this gap by analyzing the historical developments since 1945 and addressing three central issues: Why have states continued or begun programs for acquiring biological weapons? Why have states terminated biological weapons programs? How have states demonstrated that they have truly terminated their biological weapons programs?
We now live in a world in which the basic knowledge needed to develop biological weapons is more widely available than ever before. Deadly Cultures provides the lessons from history that we urgently need in order to strengthen the long-standing prohibition of biological weapons.
Foundations of Macroecology charts the evolutionary trajectory of these concepts—from the species-area relationship and the latitudinal gradient of species richness to the relationship between body size and metabolic rate—through forty-six landmark papers originally published between 1920 and 1998. Divided into two parts—“Macroecology before Macroecology” and “Dimensions of Macroecology”—the collection also takes the long view, with each paper accompanied by an original commentary from a contemporary expert in the field that places it in a broader context and explains its foundational role. Providing a solid, coherent assessment of the history, current state, and potential future of the field, Foundations of Macroecology will be an essential text for students and teachers of ecology alike.
In Frederick Novy and the Development of Bacteriology in Medicine, medical historian, medical researcher, and clinician Powel H. Kazanjian uses Novy’s archived letters, laboratory notebooks, lecture notes, and published works to examine medical research and educational activities at the University of Michigan and other key medical schools during a formative period in modern medical science.
This volume was, at the time of publication, the largest and most comprehensive book on the subject of cytology, a branch of zoology which had grown considerably in the years before 1924. It was written by the foremost cytologists in the United States, including Robert Chambers, Edwin G. Conklin, Edmund V. Cowdry, Merle H. Jacobs, Ernest E. Just, Margaret R. Lewis, Warren H. Lewis, Frank R. Lillie, Ralph S. Lillie, Clarence E. McClung, Albert P. Mathews, Thomas H. Morgan, and Edmund B. Wilson.
A fascinating ethnography of microbes that opens up new spaces for anthropological inquiry
The trillions of microbes in and on our bodies are determined by not only biology but also our social connections. Gut Anthro tells the fascinating story of how a sociocultural anthropologist developed a collaborative “anthropology of microbes” with a human microbial ecologist to address global health crises across disciplines. It asks: what would it mean for anthropology to act with science? Based partly at a preeminent U.S. lab studying the human microbiome, the Center for Genome Sciences at Washington University, and partly at a field site in Bangladesh studying infant malnutrition, it examines how microbes travel between human guts in the “field” and in microbiome laboratories, influencing definitions of health and disease, and how the microbiome can change our views on evolution, agency, and life.
As lab scientists studied the interrelationships between gut microbes and malnutrition in resource-poor countries, Amber Benezra explored ways to reconcile the scale and speed differences between the lab, the intimate biosocial practices of Bangladeshi mothers and their children, and the looming structural violence of poverty. In vital ways, Gut Anthro is about what it means to collaborate—with mothers, local field researchers in Bangladesh, massive philanthropic global health organizations, with the microbiome scientists, and, of course, with microbes. It follows microbes through various enactments in scientific research—microbes as kin, as data, and as race. Revealing how racial categories are used in microbiome research, Benezra argues that microbial differences need transdisciplinary collaboration to address racial health disparities without reifying race as a straightforward biological or social designation.
Gut Anthro is a tour de force of science studies and medical anthropology as well as an intensely personal and deeply theoretical accounting of what it means to do anthropology today.
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Black background overlaid with a pink organic path suggestive of a human digestive system. Title appears within the guts as if being processed.
The mystery of inheritance has captivated thinkers since antiquity, and the unlocking of this mystery—the development of classical genetics—is one of humanity’s greatest achievements. This great scientific and human drama is the story told fully and for the first time in this book.
Acclaimed science writer James Schwartz presents the history of genetics through the eyes of a dozen or so central players, beginning with Charles Darwin and ending with Nobel laureate Hermann J. Muller. In tracing the emerging idea of the gene, Schwartz deconstructs many often-told stories that were meant to reflect glory on the participants and finds that the “official” version of discovery often hides a far more complex and illuminating narrative. The discovery of the structure of DNA and the more recent advances in genome science represent the culmination of one hundred years of concentrated inquiry into the nature of the gene. Schwartz’s multifaceted training as a mathematician, geneticist, and writer enables him to provide a remarkably lucid account of the development of the central ideas about heredity, and at the same time bring to life the brilliant and often eccentric individuals who shaped these ideas.
In the spirit of the late Stephen Jay Gould, this book offers a thoroughly engaging story about one of the oldest and most controversial fields of scientific inquiry. It offers readers the background they need to understand the latest findings in genetics and those still to come in the search for the genetic basis of complex diseases and traits.
Written in accessible language and complemented by a glossary for easy reference, this book investigates the full scope of cellular history. Assuming only a basic knowledge of cell biology, Harold examines such pivotal subjects as the relationship between cells and genes; the central role of bioenergetics in the origin of life; the status of the universal tree of life with its three stems and viral outliers; and the controversies surrounding the last universal common ancestor. He also delves deeply into the evolution of cellular organization, the origin of complex cells, and the incorporation of symbiotic organelles, and considers the fossil evidence for the earliest life on earth. In Search of Cell History shows us just how far we have come in understanding cell evolution—and the evolution of life in general—and how far we still have to go.
Since Darwin, people have speculated about the evolutionary relationships among dissimilar species, including our connections to the diverse life forms known as microbes. In the 1970s biologists discovered a way to establish these kinships. This new era of exploration began with Linus Pauling’s finding that every protein in every cell contains a huge reservoir of evolutionary history. His discovery opened a research path that has changed the way biologists and others think about the living world. In Kin John L. Ingraham tells the story of these remarkable breakthroughs. His original, accessible history explains how we came to understand our microbe inheritance and the relatedness of all organisms on Earth.
Among the most revolutionary scientific achievements was Carl Woese’s discovery that a large group of organisms previously lumped together with bacteria were in fact a totally distinct form of life, now called the archaea. But the crowning accomplishment has been to construct the Tree of Life—an evolutionary project Darwin dreamed about over a century ago. Today, we know that the Tree’s three main stems are dominated by microbes. The nonmicrobes—plants and animals, including humans—constitute only a small upper branch in one stem.
Knowing the Tree’s structure has given biologists the ability to characterize the complex array of microbial populations that live in us and on us, and investigate how they contribute to health and disease. This knowledge also moves us closer to answering the tantalizing question of how the Tree of Life began, over 3.5 billion years ago.
Microbes create medicines, filter waste water, and clean pollution. They give cheese funky flavors, wines complex aromas, and bread a nutty crumb. Life at the Edge of Sight is a stunning visual exploration of the inhabitants of an invisible world, from the pioneering findings of a seventeenth-century visionary to magnificent close-ups of the inner workings and cooperative communities of Earth’s most prolific organisms.
Using cutting-edge imaging technologies, Scott Chimileski and Roberto Kolter lead readers through breakthroughs and unresolved questions scientists hope microbes will answer soon. They explain how microbial studies have clarified the origins of life on Earth, guided thinking about possible life on other planets, unlocked evolutionary mechanisms, and helped explain the functioning of complex ecosystems. Microbes have been harnessed to increase crop yields and promote human health.
But equally impressive, Life at the Edge of Sight opens a beautiful new frontier for readers to explore through words and images. We learn that there is more microbial biodiversity on a single frond of duckweed floating in a Delft canal than the diversity of plants and animals that biologists find in tropical rainforests. Colonies with millions of microbes can produce an array of pigments that put an artist’s palette to shame. The microbial world is ancient and ever-changing, buried in fossils and driven by cellular reactions operating in quadrillionths of a second. All other organisms have evolved within this universe of microbes, yielding intricate beneficial symbioses. With two experts as guides, the invisible microbial world awaits in plain sight.
Focusing on the tobacco mosaic virus (TMV) research conducted in Nobel laureate Wendell Stanley's lab, Creager argues that TMV served as a model system for virology and molecular biology, much as the fruit fly and laboratory mouse have for genetics and cancer research. She examines how the experimental techniques and instruments Stanley and his colleagues developed for studying TMV were generalized not just to other labs working on TMV, but also to research on other diseases such as poliomyelitis and influenza and to studies of genes and cell organelles. The great success of research on TMV also helped justify increased spending on biomedical research in the postwar years (partly through the National Foundation for Infantile Paralysis's March of Dimes)—a funding priority that has continued to this day.
Kermit the Frog famously said that it isn’t easy being green, and in Living at Micro Scale David Dusenbery shows that it isn’t easy being small—existing at the size of, say, a rotifer, a tiny multicellular animal just at the boundary between the visible and the microscopic. “Imagine,” he writes, “stepping off a curb and waiting a week for your foot to hit the ground.” At that scale, we would be small enough to swim inside the letter O in the word “rotifer.” What are the physical consequences of life at this scale? How do such organisms move, identify prey and predators and (if they’re so inclined) mates, signal to one another, and orient themselves?
In clear and engaging prose, Dusenbery uses straightforward physics to demonstrate the constraints on the size, shape, and behavior of tiny organisms. While recounting the historical development of the basic concepts, he unearths a corner of microbiology rich in history, and full of lessons about how science does or does not progress. Marshalling findings from different fields to show why tiny organisms have some of the properties they are found to have, Dusenbery shows a science that doesn’t always move triumphantly forward, and is dependent to a great extent on accident and contingency.
Though nothing in the natural world would be quite the same without them, microbes go mostly unnoticed. They are the tiny, mighty force behind the pop in Champagne and the holes in Swiss cheese, the granite walls of Yosemite and the white cliffs of Dover, the workings of snowmaking machines, Botox, and gunpowder; and yet we tend to regard them as peripheral, disease-causing, food-spoiling troublemakers. In this book renowned microbiologist John Ingraham rescues these supremely important and ubiquitous microorganisms from their unwonted obscurity by showing us how we can, in fact, see them—and appreciate their vast and varied role in nature and our lives.
Though we might not be able to see microbes firsthand, the consequences of their activities are readily apparent to our unaided senses. March of the Microbes shows us how to examine, study, and appreciate microbes in the manner of a birdwatcher, by making sightings of microbial activities and thereby identifying particular microbes as well as understanding what they do and how they do it. The sightings are as different as a smelly rock cod, a bottle of Chateau d’Yquem, a moment in the Salem witch trials, and white clouds over the ocean. Together they summarize the impact of microbes on our planet, its atmosphere, geology, weather, and other organisms including ourselves, to whom they dole out fatal illnesses and vital nutrients alike.
In the end, Ingraham leaves us marveling at the power and persistence of microbes on our planet and gives credence to Louis Pasteur’s famous assertion that “microbes will have the last word.”
In Microbes from Hell, one of the world’s leading experts on archaea and hyperthermophiles, or organisms that have evolved to flourish in extreme temperatures, offers a colorful, engaging account of this taxonomic upheaval. Blending tales of his own search for thermophiles with discussions of both the physiological challenges thermophiles face and the unique adaptations they have evolved to live in high-temperature environments, Forterre illuminates our developing understanding of the relationship between archaea and the rest of Earth’s organisms. From biotech applications to the latest discoveries in thermophile research, from microbiomes to the communities of organisms that dwell on deep-sea vents, Forterre’s exploration of life-forms that seem to thrive at the mouth of hell provides a glimpse into the early days of Earth, offering deep insight into what life may have looked like in the extreme environments of our planet’s dawn.
Why the global health project to avert emerging microbes continually fails
In 1989, a group of U.S. government scientists met to discuss some surprising findings: new diseases were appearing around the world, and viruses that they thought long vanquished were resurfacing. Their appearance heralded a future perpetually threatened by unforeseeable biological risks, sparking a new concept of disease: the “emerging microbe.” With the Cold War nearing its end, American scientists and security experts turned to confront this new “enemy,” redirecting national security against its risky horizons. In order to be fought, emerging microbes first needed to be made perceptible; but how could something immaterial, unknowable, and ever mutating be coaxed into visibility, knowability, and operability?
Microbial Resolution charts the U.S.-led war on the emerging microbe to show how their uncertain futures were transformed into objects of global science and security. Moving beyond familiar accounts that link scientific knowledge production to optical practices of visualizing the invisible, Gloria Chan-Sook Kim develops a theory of “microbial resolution” to analyze the complex problematic that arises when dealing with these entities: what can be seen when there is nothing to see? Through a syncretic analysis of data mining, animal-tracking technologies, media networks, computer-modeled futures, and global ecologies and infrastructures, she shows how a visual impasse—the impossibility of seeing microbial futures—forms the basis for new modes of perceiving, knowing, and governing in the present.
Timely and thought provoking, Microbial Resolution opens up the rich paradoxes, irreconcilabilities, and failures inherent in this project and demonstrates how these tensions profoundly animate twenty-first-century epistemologies, aesthetics, affects, and ecologies.
For three centuries, concepts of the state have been animated by one of the most powerful metaphors in politics: the body politic, a claustrophobic and bounded image of sovereignty. Climate change, neoliberalism, mass migration, and other aspects of the late Anthropocene have increasingly revealed the limitations of this metaphor. Just as the human body is not whole and separate from other bodies—comprising microbes, bacteria, water, and radioactive isotopes—Stefanie R. Fishel argues that the body politic of the state exists in dense entanglement with other communities and forms of life.
Drawing on insights from continental philosophy, science and technology studies, and international relations theory, this path-breaking book critiques the concept of the body politic on the grounds of its very materiality. Fishel both redefines and extends the metaphor of the body politic and its role in understanding an increasingly posthuman, globalized world politics. By conceiving of bodies and states as lively vessels, living harmoniously with multiplicity and the biosphere, she argues that a radical shift in metaphors can challenge a politics based on fear to open new forms of global political practice and community.
Reframing the concept of the body politic to accommodate greater levels of complexity, Fishel suggests, will result in new configurations for the political and social organization necessary to build a world in which the planet’s inhabitants do not merely live but actively thrive.
The geochemical processes that take place in water bodies do not stem entirely from the activity of bacteria, but are also determined by the biological activity of higher plants and animals. The Microflora of Lakes and Its Geochemical Activity, the first English translation of the work of S. I. Kuznetsov, renowned Soviet microbiologist, is a detailed description of these processes.
The Microflora of Lakes opens with a complete outline of the ecology and physical and chemical properties of water bodies and a discussion of the entire complex of hydrobionts, since these factors exert tremendous influence on the microbial population. The work then focuses on the principles of the morphology and physiology of the living cell, background knowledge essential to the understanding of the role of microorganisms in the chemical cycle. Having laid the groundwork for the discussion, Kuznetsov follows with chapters on the distribution of bacteria and transformations of organic matter in lakes. He then examines the role of bacteria in the oxygen regime, and the cycles of organic matter, nitrogen, sulfur, iron, manganese and phosphorus. The last chapter describes the role of microorganisms in sediments of calcium carbonate waters.
The Microflora of Lakes and Its Geochemical Activity provides a wealth of information on the microbial limnology of fresh-water lakes throughout the world, particularly in the Soviet Union. As a summary of the geochemical activities as related to the geographic, geological, and physical relationships of fresh-water lakes, it is a monumental study.
The Microflora of Lakes was translated for the National Science Foundation, Washington, D.C., by the Israel Program for Scientific Translations in Jerusalem.
Fortunately, scientists are finding new solutions that work with, rather than against, nature. Emily Monosson explores science’s most innovative strategies, from high-tech gene editing to the ancient practice of fecal transplants. There are viruses that infect and bust apart bacteria; vaccines engineered to better provoke our natural defenses; and insect pheromones that throw crop-destroying moths into a misguided sexual frenzy. Some technologies will ultimately fizzle; others may hold the key to abundant food and unprecedented health. Each represents a growing understanding of how to employ ecology for our own protection.
Monosson gives readers a peek into the fascinating and hopeful world of natural defenses. Her book is full of optimism, not simply for particular cures, but for a sustainable approach to human welfare that will benefit generations to come.
What can one man accomplish, even a great man and brilliant scientist? Although every town in France has a street named for Louis Pasteur, was he alone able to stop people from spitting, persuade them to dig drains, influence them to undergo vaccination? Pasteur’s success depended upon a whole network of forces, including the public hygiene movement, the medical profession (both military physicians and private practitioners), and colonial interests. It is the operation of these forces, in combination with the talent of Pasteur, that Bruno Latour sets before us as a prime example of science in action.
Latour argues that the triumph of the biologist and his methodology must be understood within the particular historical convergence of competing social forces and conflicting interests. Yet Pasteur was not the only scientist working on the relationships of microbes and disease. How was he able to galvanize the other forces to support his own research? Latour shows Pasteur’s efforts to win over the French public—the farmers, industrialists, politicians, and much of the scientific establishment.
Instead of reducing science to a given social environment, Latour tries to show the simultaneous building of a society and its scientific facts. The first section of the book, which retells the story of Pasteur, is a vivid description of an approach to science whose theoretical implications go far beyond a particular case study. In the second part of the book, “Irreductions,” Latour sets out his notion of the dynamics of conflict and interaction, of the “relation of forces.” Latour’s method of analysis cuts across and through the boundaries of the established disciplines of sociology, history, and the philosophy of science, to reveal how it is possible not to make the distinction between reason and force. Instead of leading to sociological reductionism, this method leads to an unexpected irreductionism.
This fully revised edition of Phylogeny and Evolution of the Angiosperms provides an up-to-date, comprehensive overview of the evolution of and relationships among these vital plants. Incorporating molecular phylogenetics with morphological, chemical, developmental, and paleobotanical data, as well as presenting a more detailed account of early angiosperm fossils and important fossil information for each evolutionary branch of the angiosperms, the new edition integrates fossil evidence into a robust phylogenetic framework. Featuring a wealth of new color images, this highly synthetic work further reevaluates long-held evolutionary hypotheses related to flowering plants and will be an essential reference for botanists, plant systematists, and evolutionary biologists alike.
In Planet of Microbes, Ted Anton takes readers through the most recent discoveries about microbes, revealing their unexpected potential to reshape the future of the planet. For years, we knew little about these invisible invaders, considering them as little more than our enemies in our fight against infectious disease. But the more we learn about microbes, the more it’s become clear that our very lives depend on them. They may also hold the answers to some of science’s most pressing problems, including how to combat a warming planet, clean up the environment, and help the body fight off a wide variety of diseases. Anton has spent years interviewing and working with the determined scientists who hope to harness the work of microbes, and he breaks down the science while also sharing incredible behind-the-scenes stories of the research taking place everywhere from microbreweries to Mars.
The world’s tiniest organisms were here more than three billion years before us. We live in their world, and Planet of Microbes at last gives these unsung heroes the recognition they deserve.
For years, scientists have been warning us that a pandemic was all but inevitable. Now it's here, and the rest of us have a lot to learn.
Fortunately, science writer Carl Zimmer is here to guide us. In this compact volume, he tells the story of how the smallest living things known to science can bring an entire planet of people to a halt--and what we can learn from how we've defeated them in the past.
Planet of Viruses covers such threats as Ebola, MERS, and chikungunya virus; tells about recent scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and shares new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and, for all its honesty about the threats, as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a world we all need to better understand.
Fortunately, science writer Carl Zimmer is here to guide us. In this compact volume, he tells the story of how the smallest living things known to science can bring an entire planet of people to a halt--and what we can learn from how we've defeated them in the past.
Planet of Viruses covers such threats as Ebola, MERS, and chikungunya virus; tells about recent scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and shares new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and, for all its honesty about the threats, as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a world we all need to better understand.
In recent years, issues of infection prevention and control, patient safety, and quality-of-care have become increasingly prominent in healthcare facilities. Practical Healthcare Epidemiology takes a practical, hands-on approach to these issues, addressing all aspects of infection surveillance and prevention in clear, straightforward terms. This fully revised third edition brings together the expertise of more than fifty leaders in healthcare epidemiology who provide clear, sound guidance on infection prevention and control for the full range of patients in all types of healthcare facilities, including those in settings with limited resources. A powerful resource for practitioners in any branch of medicine or public health who are involved in infection prevention and control, whether they are experienced in healthcare epidemiology or new to the field.
“A handy desk reference and an up-to-date primer for trainees and experts alike” —The Journal of the American Medical Association
“An essential for anyone in the field.”—Thomas R. Talbot, Chief Hospital Epidemiologist, Vanderbilt University Medical Center
Assesses a promising new approach to restoring the health of our bodies and our planet
Most of us are familiar with probiotics added to milk or yogurt to improve gastrointestinal health. In fact, the term refers to any intervention in which life is used to manage life—from the microscopic, like consuming fermented food to improve gut health, to macro approaches such as biological pest control and natural flood management. In this ambitious and original work, Jamie Lorimer offers a sweeping overview of diverse probiotic approaches and an insightful critique of their promise and limitations.
During our current epoch—the Anthropocene—human activity has been the dominant influence on climate and the environment, leading to the loss of ecological abundance, diversity, and functionality. Lorimer describes cases in which scientists and managers are working with biological processes to improve human, environmental, and even planetary health, pursuing strategies that stand in contrast to the “antibiotic approach”: Big Pharma, extreme hygiene, and industrial agriculture. The Probiotic Planet focuses on two forms of “rewilding” occurring on vastly different scales. The first is the use of keystone species like wolves and beavers as part of landscape restoration. The second is the introduction of hookworms into human hosts to treat autoimmune disorders. In both cases, the goal is to improve environmental health, whether the environment being managed is planetary or human. Lorimer argues that, all too often, such interventions are viewed in isolation, and he calls for a rethinking of artificial barriers between science and policy. He also describes the stark and unequal geographies of the use of probiotic approaches and examines why these patterns exist.
The author’s preface provides a thoughtful discussion of the COVID-19 pandemic as it relates to the probiotic approach. Informed by deep engagement with microbiology, immunology, ecology, and conservation biology as well as food, agriculture, and waste management, The Probiotic Planet offers nothing less than a new paradigm for collaboration between the policy realm and the natural sciences.
As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change–related threats confronting humanity.
Even without deadly global catastrophes on the scale of the 1918 Spanish Influenza pandemic, emerging diseases cost humanity more than a trillion dollars per year in treatment and lost productivity. But while time is short, the danger is great, and we are largely unprepared, the Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can “anticipate to mitigate” emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.
Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Resistance develops because the bacteria that antibiotics target can evolve ways to defend themselves against these drugs. When antibiotics fail, there is very little else to prevent an infection from spreading.
Unnecessary use of antibiotics in both humans and animals accelerates the evolution of drug-resistant bacteria, with potentially catastrophic personal and global consequences. Our best defenses against infectious disease could cease to work, surgical procedures would become deadly, and we might return to a world where even small cuts are life-threatening. The problem of drug resistance already kills over one million people across the world every year and has huge economic costs. Without action, this problem will become significantly worse.
Following from their work on the Review on Antimicrobial Resistance, William Hall, Anthony McDonnell, and Jim O’Neill outline the major systematic failures that have led to this growing crisis. They also provide a set of solutions to tackle these global issues that governments, industry, and public health specialists can adopt. In addition to personal behavioral modifications, such as better handwashing regimens, Superbugs argues for mounting an offense against this threat through agricultural policy changes, an industrial research stimulus, and other broad-scale economic and social incentives.
More than eighty years ago, before we knew much about the structure of cells, Russian botanist Boris Kozo-Polyansky brilliantly outlined the concept of symbiogenesis, the symbiotic origin of cells with nuclei. It was a half-century later, only when experimental approaches that Kozo-Polyansky lacked were applied to his hypotheses, that scientists began to accept his view that symbiogenesis could be united with Darwin's concept of natural selection to explain the evolution of life. After decades of neglect, ridicule, and intellectual abuse, Kozo-Polyansky's ideas are now endorsed by virtually all biologists.
Kozo-Polyansky's seminal work is presented here for the first time in an outstanding annotated translation, updated with commentaries, references, and modern micrographs of symbiotic phenomena.
DNA profiling—commonly known as DNA fingerprinting—is often heralded as unassailable criminal evidence, a veritable “truth machine” that can overturn convictions based on eyewitness testimony, confessions, and other forms of forensic evidence. But DNA evidence is far from infallible. Truth Machine traces the controversial history of DNA fingerprinting by looking at court cases in the United States and United Kingdom beginning in the mid-1980s, when the practice was invented, and continuing until the present. Ultimately, Truth Machine presents compelling evidence of the obstacles and opportunities at the intersection of science, technology, sociology, and law.
The robotic rovers Spirit and Opportunity made headlines as they scraped their way across the Martian landscape, searching for signs of life. But while our eyes have been turned toward the skies, teeming beneath us and largely unexplored lies what Science magazine recently called the true "final frontier." A growing array of scientists is exploring life in soils and sediments, uncovering a living world literally alien to our own senses--and yet one whose integrity turns out to be crucial to life above ground.
Yvonne Baskin takes the reader from the polar desert of Antarctica to the coastal rain forests of Canada, from the rangelands of Yellowstone National Park to the vanishing wetlands of the Mississippi River basin, from Dutch pastures to English sounds, and beyond. She introduces exotic creatures--from bacteria and fungi to microscopic nematode worms, springtails, and mud shrimp--and shows us what scientists are learning about their contribution to sustaining a green and healthy world above ground. She also explores the alarming ways in which air pollution, trawl fishing, timber cutting, introductions of invasive species, wetland destruction, and the like threaten this underground diversity and how their loss, in turn, affects our own well being.
Two-thirds of the world's biological diversity exists in soils and underwater sediments, and yet most of us remain unaware of these tiny multitudes that run the planet beneath the scenes. In Under Ground, Baskin reveals the startling ways in which that life, whether in our own back yards, in fields and forests, or in the furthest reaches of the Earth, is more numerous, significant, and fascinating than we once imagined.
In punishment for his stealing fire, the Greek gods chained Prometheus to a rock, where every day an eagle plucked out his liver, and every night the liver regenerated. While Prometheus may be a figure of myth, scholars today ask whether ancient Greeks knew that the human liver does, in fact, have a special capacity to regenerate. Some organs and tissues can regenerate, while others cannot, and some organisms can regenerate more fully and more easily than others. Cut an earthworm in half, and two wiggly worms may confront you. Cut off the head of a hydra, and it may grow a new head. Cut off a human arm, and the human will be missing an arm. Why the differences? What are the limits of regeneration, and how, when, and why does it occur?
In this book, historians and philosophers of science Jane Maienschein and Kate MacCord explore biological regeneration, delving into a topic of increasing interest in light of regenerative medicine, new tools in developmental and neurobiology, and the urgent need to understand and repair damage to ecosystems brought on by climate change. Looking across scales, from germ, nerve, and stem cells to individual organisms and complex systems, this short and accessible introduction poses a range of deep and provocative questions: What conditions allow some damaged microbiomes to regenerate where others do not? Why are forests following a fire said to regenerate sometimes but not always? And in the face of climate change in the era called the Anthropocene, can the planet regenerate to become healthy again, or will the global ecosystem collapse?
Psychoanalyst, political theorist, pioneer of body therapies, prophet of the sexual revolution—all fitting titles, but Wilhelm Reich has never been recognized as a serious laboratory scientist, despite his experimentation with bioelectricity and unicellular organisms. Wilhelm Reich, Biologist is an eye-opening reappraisal of one of twentieth-century science’s most controversial figures—perhaps the only writer whose scientific works were burned by both the Nazis and the U.S. government. Refuting allegations of “pseudoscience” that have long dogged Reich’s research, James Strick argues that Reich’s lab experiments in the mid-1930s represented the cutting edge of light microscopy and time-lapse micro-cinematography and deserve to be taken seriously as legitimate scientific contributions.
Trained in medicine and a student of Sigmund Freud, Reich took to the laboratory to determine if Freud’s concept of libido was quantitatively measurable. His electrophysiological experiments led to his “discovery” of microscopic vesicles (he called them “bions”), which Reich hypothesized were instrumental in originating life from nonliving matter. Studying Reich’s laboratory notes from recently opened archives, Strick presents a detailed account of the bion experiments, tracing how Reich eventually concluded he had discovered an unknown type of biological radiation he called “orgone.” The bion experiments were foundational to Reich’s theory of cancer and later investigations of orgone energy.
Reich’s experimental findings and interpretations were considered discredited, but not because of shoddy lab technique, as has often been claimed. Scientific opposition to Reich’s experiments, Strick contends, grew out of resistance to his unorthodox sexual theories and his Marxist political leanings.
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