Throughout his remarkable career, Donald Pfaff has demonstrated that by choosing problems and methods with care, biologists can study the molecular mechanisms of brains more complex than those of fruit flies, snails, roundworms, and other invertebrates. His half century in the lab, starting with his discovery of hormone receptors in the brains of mammals and leading to the first detailed account of a neural circuit for mammalian behavior, puts him in a unique position to survey the origins and development of behavioral neurobiology and the current state of research. How the Vertebrate Brain Regulates Behavior offers a close-up, conversational perspective on scientific struggles and successes throughout a fifty-year quest to understand how behavior is regulated in a complex organism.

In graduate school, when Pfaff expressed a desire to study behavioral regulation, his advisor suggested focusing on hormones. Pfaff’s investigation into the hormonal basis of female sexual behavior in laboratory rats led him to a comprehensive appreciation of how hormone-dependent neurons work through neural circuits to produce discrete behaviors among all vertebrates. This breakthrough, along with other researchers’ findings, established a link between molecular biology and neuroscience that opened up a fruitful new field of inquiry.

Pfaff’s approach is to focus on one solvable problem and explore it from many angles. He begins with a single observed behavior and traces its regulation through a series of biological mechanisms—from hormones to genes to neural circuits. Pfaff’s relentless pursuit of his goals continues to inspire neuroscientists today.

If we are to understand the brain, we must understand how the individual molecules and cells of the nervous system function and ultimately contribute to our behavior. Molecular and Cellular Physiology of Neurons provides a comprehensive and up-to-date account of what we now know—and what we want to know and can reasonably expect to discover in the near future—about the functioning of the brain at the level of molecules and cells.

Molecular and Cellular Physiology of Neurons takes readers from the fundamentals to the most sophisticated concepts and latest discoveries: from membrane potentials to recent experiments on voltage-gated ion channels, from descriptions of receptors, G proteins, effector molecules, and second messengers to an account of our current understanding of long-term potentiation.

In each chapter Fain discusses individual experiments that have made crucial contributions to our knowledge and that illustrate the techniques and approaches that have formed our present view of nerve cell function. Extensive illustrations add to this vivid account of not only what we know about cellular and molecular neurophysiology but how we know it.