With the recent Sokal hoax--the publication of a prominent physicist's pseudo-article in a leading journal of cultural studies--the status of science moved sharply from debate to dispute. Is science objective, a disinterested reflection of reality, as Karl Popper and his followers believed? Or is it subjective, a social construction, as Thomas Kuhn and his students maintained? Into the fray comes Mystery of Mysteries, an enlightening inquiry into the nature of science, using evolutionary theory as a case study.

Michael Ruse begins with such colorful luminaries as Erasmus Darwin (grandfather of Charles) and Julian Huxley (brother of novelist Aldous and grandson of T. H. Huxley, "Darwin's bulldog" ) and ends with the work of the English game theorist Geoffrey Parker--a microevolutionist who made his mark studying the mating strategies of dung flies--and the American paleontologist Jack Sepkoski, whose computer-generated models reconstruct mass extinctions and other macro events in life's history. Along the way Ruse considers two great popularizers of evolution, Richard Dawkins and Stephen Jay Gould, as well as two leaders in the field of evolutionary studies, Richard Lewontin and Edward O. Wilson, paying close attention to these figures' cultural commitments: Gould's transplanted Germanic idealism, Dawkins's male-dominated Oxbridge circle, Lewontin's Jewish background, and Wilson's southern childhood. Ruse explicates the role of metaphor and metavalues in evolutionary thought and draws significant conclusions about the cultural impregnation of science. Identifying strengths and weaknesses on both sides of the "science wars," he demonstrates that a resolution of the objective and subjective debate is nonetheless possible.

This is a historical review of the development of our knowledge of the clinical picture, etiology, pathogenesis, and prevention of rheumatic fever and rheumatic heart disease over the past four centuries. Benedict Massell examines the major contributions of both clinicians and investigators to our current understanding of rheumatic fever as a separate disease form.

Elucidating many facts about this dread disease, Massell examines the frequent epidemics in training camps during World War II, discusses our growing understanding of the pathogenesis and mechanisms by which streptococcal infections cause the disease, and shows the important progress made in prevention through the use of penicillin and other antibiotics. He includes a discussion of the many problems which can hinder our understanding and control of this disease, as well as recent promising developments in the clarification of the molecular structure of the streptococcal protein and the possible application of this information to the development of a safe and effective vaccine for the prevention of streptococcal infection.