front cover of Chasing the Red Queen
Chasing the Red Queen
The Evolutionary Race Between Agricultural Pests and Poisons
Andy Dyer
Island Press, 2015
In the race to feed the world’s seven billion people, we are at a standstill. Over the past century, we have developed increasingly potent and sophisticated pesticides, yet in 2014, the average percentage of U.S. crops lost to agricultural pests was no less than in 1944. To use a metaphor the field of evolutionary biology borrowed from Alice in Wonderland, farmers must run ever faster to stay in the same place—i.e., produce the same yields.

With Chasing the Red Queen, Andy Dyer offers the first book to apply the Red Queen Hypothesis to agriculture. He illustrates that when selection pressure increases, species evolve in response, creating a never-ending, perpetually-escalating competition between predator (us) and prey (bugs and weeds). The result is farmers are caught in a vicious cycle of chemical dependence, stuck using increasingly dangerous and expensive toxics to beat back progressively resistant pests.

To break the cycle, we must learn the science behind it. Dyer examines one of the world’s most pressing problems as a biological case study. He presents key concepts, from Darwin’s principles of natural selection to genetic variation and adaptive phenotypes. Understanding the fundamentals of ecology and biology is the first step to “playing the Red Queen,” and escaping her unwinnable race. The book’s novel frame will help students, researchers, and policy-makers alike apply that knowledge to the critical task of achieving food security.
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front cover of Modern Poisons
Modern Poisons
A Brief Introduction to Contemporary Toxicology
Alan S. Kolok
Island Press, 2014
Traditional toxicology textbooks tend to be doorstops: tomes filled with important but seemingly abstract chemistry and biology. Meanwhile, magazine and journal articles introduce students to timely topics such as BPA and endocrine disruption or the carcinogenic effects of pesticides, but don’t provide the fundamentals needed to understand the science of toxicity. Written by a longtime professor of toxicology, Modern Poisons bridges this gap.

This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts of the field such as the dose-response relationship and the concept, first introduced by Ambroise Paré in the sixteenth century, that a chemical’s particular action depends on its inherent chemical nature. The author goes on to show exactly how chemicals enter the body and elicit their toxic effect, as well as the body’s methods of defense.

With the fundamentals established, Kolok digs into advances in toxicology, tracing the field’s development from World War II to the present day. The book examines both technical discoveries and their impacts on public policy. Highlights include studies of endocrine-disrupting chemicals in toiletries and prescriptions, the emerging science on prions, and our growing understanding of epigenetics.

Readers learn not only how toxic exposure affects people and wildlife, but about the long-term social and environmental consequences of our chemicals. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of—and curiosity about—this fast-changing field.
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front cover of Phytomedicines, Herbal Drugs, and Poisons
Phytomedicines, Herbal Drugs, and Poisons
Edited by Ben-Erik van Wyk and Michael Wink
University of Chicago Press, 2015
Plants have been used to treat disease throughout human history. On a clay slab that dates back approximately five thousand years, the Sumerians recorded medicinal recipes that made use of hundreds of plants, including poppy, henbane, and mandrake. During the Middle Ages, monks commonly grew and prescribed plants such as sage, anise, and mint in their monasteries. And as the market for herbal remedies and natural medicine grows, we continue to search the globe for plants and plant compounds to combat our various ailments.
           
In Phytomedicines, Herbal Drugs, and Poisons, Ben-Erik van Wyk offers a richly illustrated, scientific guide to medicinal and poisonous plants, including those used for their mind-altering effects. Van Wyk covers approximately 350 species—from Aloe vera and Ephedra sinica to Cannabis sativa and Coffea arabica—detailing their botanical, geographical, pharmacological, and toxicological data as well as the chemical structures of the active compounds in each. Readers learn, for example, that Acacia senegal, or gum acacia, is used primarily in Sudan and Ethiopia as a topical ointment to protect the skin and mucosa from bacterial and fungal infections, and that Aconitum napellus, more commonly known as aconite, is used in cough syrups but can be psychedelic when smoked or absorbed through the skin. 
               
With 350 full-color photographs featuring the plants and some of their derivative products, Phytomedicines, Herbal Drugs, and Poisons will be an invaluable reference not only for those in the health care field but also for those growing their own medicinal herb gardens, as well as anyone who needs a quick answer to whether a plant is a panacea or a poison.
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front cover of The Poison Trials
The Poison Trials
Wonder Drugs, Experiment, and the Battle for Authority in Renaissance Science
Alisha Rankin
University of Chicago Press, 2021
In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story.

At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend.

The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.
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