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44 books match the query 'Biotechnology'

cover of A Primer for Computational Biology

A Primer for Computational Biology

Shawn T. O'Neil

Oregon State University Press, 2017

A Primer for Computational Biology aims to provide life scientists and students the skills necessary for research in a data-rich world. The text covers accessing and using remote servers via the command-line, writing programs and pipelines for data analysis, and provides useful vocabulary for interdisciplinary work. The book is broken into three parts:

  1. Introduction to Unix/Linux: The command-line is the “natural environment” of scientific computing, and this part covers a wide range of topics, including logging in, working with files and directories, installing programs and writing scripts, and the powerful “pipe” operator for file and data manipulation.
  2. Programming in Python: Python is both a premier language for learning and a common choice in scientific software development. This part covers the basic concepts in programming (data types, if-statements and loops, functions) via examples of DNA-sequence analysis. This part also covers more complex subjects in software development such as objects and classes, modules, and APIs.
  3. Programming in R: The R language specializes in statistical data analysis, and is also quite useful for visualizing large datasets. This third part covers the basics of R as a programming language (data types, if-statements, functions, loops and when to use them) as well as techniques for large-scale, multi-test analyses. Other topics include S3 classes and data visualization with ggplot2.
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cover of Asian Biotech: Ethics and Communities of Fate

Asian Biotech

Ethics and Communities of Fate

Aihwa Ong and Nancy N. Chen, eds.

Duke University Press, 2010

Providing the first overview of Asia’s emerging biosciences landscape, this timely and important collection brings together ethnographic case studies on biotech endeavors such as genetically modified foods in China, clinical trials in India, blood collection in Singapore and China, and stem-cell research in Singapore, South Korea, and Taiwan. While biotech policies and projects vary by country, the contributors identify a significant trend toward state entrepreneurialism in biotechnology, and they highlight the ways that political thinking and ethical reasoning are converging around the biosciences. As ascendant nations in a region of postcolonial emergence, with an “uncanny surplus” in population and pandemics, Asian countries treat their populations as sources of opportunity and risk. Biotech enterprises are allied to efforts to overcome past humiliations and restore national identity and political ambition, and they are legitimized as solutions to national anxieties about food supplies, diseases, epidemics, and unknown biological crises in the future. Biotechnological responses to perceived risks stir deep feelings about shared fate, and they crystallize new ethical configurations, often re-inscribing traditional beliefs about ethnicity, nation, and race. As many of the essays in this collection illustrate, state involvement in biotech initiatives is driving the emergence of “biosovereignty,” an increasing pressure for state control over biological resources, commercial health products, corporate behavior, and genetic based-identities. Asian Biotech offers much-needed analysis of the interplay among biotechnologies, economic growth, biosecurity, and ethical practices in Asia.

Contributors
Vincanne Adams
Nancy N. Chen
Stefan Ecks
Kathleen Erwin
Phuoc V. Le
Jennifer Liu
Aihwa Ong
Margaret Sleeboom-Faulkner
Kaushik Sunder Rajan
Wen-Ching Sung
Charis Thompson
Ara Wilson

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cover of Bio-Imperialism: Disease, Terror, and the Construction of National Fragility

Bio-Imperialism

Disease, Terror, and the Construction of National Fragility

Gwen Shuni D'Arcangelis

Rutgers University Press, 2021

Bio-Imperialism focuses on an understudied dimension of the war on terror: the fight against bioterrorism. This component of the war enlisted the biosciences and public health fields to build up the U.S. biodefense industry and U.S. global disease control. The book argues that U.S. imperial ambitions drove these shifts in focus, aided by gendered and racialized discourses on terrorism, disease, and science. These narratives helped rationalize American research expansion into dangerous germs and bioweapons in the name of biodefense and bolstered the U.S. rationale for increased interference in the disease control decisions of Global South nations. Bio-Imperialism is a sobering look at how the war on terror impacted the world in ways that we are only just starting to grapple with.
 
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cover of Biocapital: The Constitution of Postgenomic Life

Biocapital

The Constitution of Postgenomic Life

Kaushik Sunder Rajan

Duke University Press, 2006

Biocapital is a major theoretical contribution to science studies and political economy. Grounding his analysis in a multi-sited ethnography of genomic research and drug development marketplaces in the United States and India, Kaushik Sunder Rajan argues that contemporary biotechnologies such as genomics can only be understood in relation to the economic markets within which they emerge. Sunder Rajan conducted fieldwork in biotechnology labs and in small start-up companies in the United States (mostly in the San Francisco Bay area) and India (mainly in New Delhi, Hyderabad, and Bombay) over a five-year period spanning 1999 to 2004. He draws on his research with scientists, entrepreneurs, venture capitalists, and policymakers to compare drug development in the two countries, examining the practices and goals of research, the financing mechanisms, the relevant government regulations, and the hype and marketing surrounding promising new technologies. In the process, he illuminates the global flow of ideas, information, capital, and people connected to biotech initiatives.

Sunder Rajan’s ethnography informs his theoretically sophisticated inquiry into how the contemporary world is shaped by the marriage of biotechnology and market forces, by what he calls technoscientific capitalism. Bringing Marxian theories of value into conversation with Foucaultian notions of biopolitics, he traces how the life sciences came to be significant producers of both economic and epistemic value in the late twentieth century and early twenty-first.

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cover of Biomedia

Biomedia

Eugene Thacker

University of Minnesota Press, 2004

The merging of computer science and molecular biology, genetic codes and computer codes

As biotechnology defines the new millennium, genetic codes and computer codes increasingly merge—life understood as data, flesh rendered programmable. Where this trend will take us, and what it might mean, is what concerns Eugene Thacker in this timely book, a penetrating look into the intersection of molecular biology and computer science in our day and its likely ramifications for the future.

Integrating approaches from science and media studies, Biomedia is a critical analysis of research fields that explore relationships between biologies and technologies, between genetic and computer “codes.” In doing so, the book looks beyond the familiar examples of cloning, genetic engineering, and gene therapy—fields based on the centrality of DNA or genes—to emerging fields in which “life” is often understood as “information.” Focusing especially on interactions between genetic and computer codes, or between “life” and “information,” Thacker shows how each kind of “body” produced—from biochip to DNA computer—demonstrates how molecular biology and computer science are interwoven to provide unique means of understanding and controlling living matter.Throughout, Thacker provides in-depth accounts of theoretical issues implicit in biotechnical artifacts—issues that arise in the fields of bioinformatics, proteomics, systems biology, and biocomputing. Research in biotechnology, Biomedia suggests, flouts our assumptions about the division between biological and technological systems. New ways of thinking about this division are needed if we are to understand the cultural, social, and philosophical dimensions of such research, and this book marks a significant advance in the coming intellectual revolution.
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cover of Biomedicalization: Technoscience, Health, and Illness in the U.S.

Biomedicalization

Technoscience, Health, and Illness in the U.S.

Adele E. Clarke, Laura Mamo, Jennifer Ruth Fosket, Jennifer R. Fishman, and Janet K. Shim, eds.

Duke University Press, 2010

The rise of Western scientific medicine fully established the medical sector of the U.S. political economy by the end of the Second World War, the first “social transformation of American medicine.” Then, in an ongoing process called medicalization, the jurisdiction of medicine began expanding, redefining certain areas once deemed moral, social, or legal problems (such as alcoholism, drug addiction, and obesity) as medical problems. The editors of this important collection argue that since the mid-1980s, dramatic, and especially technoscientific, changes in the constitution, organization, and practices of contemporary biomedicine have coalesced into biomedicalization, the second major transformation of American medicine. This volume offers in-depth analyses and case studies along with the groundbreaking essay in which the editors first elaborated their theory of biomedicalization.

Contributors. Natalie Boero, Adele E. Clarke, Jennifer R. Fishman, Jennifer Ruth Fosket, Kelly Joyce, Jonathan Kahn, Laura Mamo, Jackie Orr, Elianne Riska, Janet K. Shim, Sara Shostak

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cover of Biophysical Models and Applications in Ecosystem Analysis

Biophysical Models and Applications in Ecosystem Analysis

Chen, Jiquan

Michigan State University Press, 2021

The past five decades have witnessed a rapid growth of computer models for simulating ecosystem functions and dynamics. This has been fueled by the availability of remote sensing data, computation capability, and cross-disciplinary knowledge. These models contain many submodules for simulating different processes and forcing mechanisms, albeit it has become challenging to truly understand the details due to their complexity. Most ecosystem models, fortunately, are rooted in a few core biophysical foundations, such as the widely recognized Farquhar model, Ball-Berry-Leuning and Medlyn family models, Penman-Monteith equation, Priestley-Taylor model, and Michaelis-Menten kinetics. After an introduction of biophysical essentials, four chapters present the core algorithms and their behaviors in modeling ecosystem production, respiration, evapotranspiration, and global warming potentials. Each chapter is composed of a brief introduction of the literature, in which model algorithms, their assumptions, and performances are described in detail. Spreadsheet (or Python codes) templates are included in each chapter for modeling exercises with different input parameters as online materials, which include datasets, parameter estimation, and real-world applications (e.g., calculations of global warming potentials). Users can also apply their own datasets. The materials included in this volume serve as effective tools for users to understand model behaviors and uses with specified conditions and in situ applications. 
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cover of Biotechnology and Society: An Introduction

Biotechnology and Society

An Introduction

Hallam Stevens

University of Chicago Press, 2016

With Biotechnology and Society, Hallam Stevens offers an up-to-date primer to help us understand the interactions of biotechnology and society and the debates, controversies, fears, and hopes that have shaped how we think about bodies, organisms, and life in the twenty-first century. Stevens addresses such topics as genetically modified foods, cloning, and stem cells; genetic testing and the potential for discrimination; fears of (and, in some cases, hopes for) designer babies; personal genomics; biosecurity; and biotech art. Taken as a whole, the book presents a clear, authoritative picture of the relationship between biotechnology and society today, and how our conceptions (and misconceptions) of it could shape future developments. It is an essential volume for students and scholars working with biotechnology, while still being accessible to the general reader interested in the truth behind breathless media accounts about biotech’s promise and perils.
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cover of Brutes or Angels: Human Possibility in the Age of Biotechnology

Brutes or Angels

Human Possibility in the Age of Biotechnology

James T. Bradley

University of Alabama Press, 2013

A guide to the rapidly progressing Age of Biotechnology, Brutes or Angels provides basic information on a wide array of new technologies in the life sciences, along with the ethical issues raised by each

With stem cell research, Dolly the cloned sheep, in vitro fertilization, age retardation, and pharmaceutical mind enhancement, humankind is now faced with decisions that it has never before had to consider. The thoughtfulness, or lack of it, that we bring to those decisions will largely determine the future character of the living world.
 
Brutes or Angels will facilitate informed choice making about the personal use of biotechnologies and the formulation of public policies governing their development and use. Ten biotechnologies that impact humans are considered: stem cell research, embryo selection, human genomics, gene therapies, human reproductive cloning, age retardation, cognition enhancement, the engineering of nonhuman organisms, nanobiology, and synthetic biology.
 
With deft and assured use of metaphors, analogies, diagrams, and photographs, James T. Bradley introduces important biological principles and the basic procedures used in biotechnology. Various ethical issues--personhood, personal identity, privacy, ethnic discrimination, distributive justice, authenticity and human nature, and the significance of mortality in the human life cycle--are presented in a clear and unbiased manner. Personal reflection and group dialogue are encouraged by questions at the end of each chapter, making this book not only a general guide to better informed and nuanced thinking on these complex and challenging topics but also an appropriate text for bioethics courses in university science departments and for adult education classes.
 
Standing at the beginning of the twenty-first century, with burgeoning abilities to enhance and even create life in ways unimaginable just a few decades ago, humans have an awesome responsibility to themselves and other species. Brutes or Angels invites us to engage each other in meaningful dialogue by listening, gathering information, formulating thoughtful views, and remaining open to new knowledge and ethical argumentation.
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cover of Corporate Crops: Biotechnology, Agriculture, and the Struggle for Control

Corporate Crops

Biotechnology, Agriculture, and the Struggle for Control

By Gabriela Pechlaner

University of Texas Press, 2012

Biotechnology crop production area increased from 1.7 million hectares to 148 million hectares worldwide between 1996 to 2010. While genetically modified food is a contentious issue, the debates are usually limited to health and environmental concerns, ignoring the broader questions of social control that arise when food production methods become corporate-owned intellectual property. Drawing on legal documents and dozens of interviews with farmers and other stakeholders, Corporate Crops covers four case studies based around litigation between biotechnology corporations and farmers. Pechlaner investigates the extent to which the proprietary aspects of biotechnologies—from patents on seeds to a plethora of new rules and contractual obligations associated with the technologies—are reorganizing crop production.

The lawsuits include patent infringement litigation launched by Monsanto against a Saskatchewan canola farmer who, in turn, claimed his crops had been involuntarily contaminated by the company’s GM technology; a class action application by two Saskatchewan organic canola farmers launched against Monsanto and Aventis (later Bayer) for the loss of their organic market due to contamination with GMOs; and two cases in Mississippi in which Monsanto sued farmers for saving seeds containing its patented GM technology. Pechlaner argues that well-funded corporate lawyers have a decided advantage over independent farmers in the courts and in creating new forms of power and control in agricultural production. Corporate Crops demonstrates the effects of this intersection between the courts and the fields where profits, not just a food supply, are reaped.

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cover of Cultivating Knowledge: Biotechnology, Sustainability, and the Human Cost of Cotton Capitalism in India

Cultivating Knowledge

Biotechnology, Sustainability, and the Human Cost of Cotton Capitalism in India

Andrew Flachs

University of Arizona Press, 2019

A single seed is more than just the promise of a plant. In rural south India, seeds represent diverging paths toward a sustainable livelihood. Development programs and global agribusiness promote genetically modified seeds and organic certification as a path toward more sustainable cotton production, but these solutions mask a complex web of economic, social, political, and ecological issues that may have consequences as dire as death.

In Cultivating Knowledge anthropologist Andrew Flachs shows how rural farmers come to plant genetically modified or certified organic cotton, sometimes during moments of agrarian crisis. Interweaving ethnographic detail, discussions of ecological knowledge, and deep history, Flachs uncovers the unintended consequences of new technologies, which offer great benefits to some—but at others’ expense. Flachs shows that farmers do not make simple cost-benefit analyses when evaluating new technologies and options. Their evaluation of development is a complex and shifting calculation of social meaning, performance, economics, and personal aspiration. Only by understanding this complicated nexus can we begin to understand sustainable agriculture.

By comparing the experiences of farmers engaged with these mutually exclusive visions for the future of agriculture, Cultivating Knowledge investigates the human responses to global agrarian change. It illuminates the local impact of global changes: the slow, persistent dangers of pesticides, inequalities in rural life, the aspirations of people who grow fibers sent around the world, the place of ecological knowledge in modern agriculture, and even the complex threat of suicide. It all begins with a seed.

 
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cover of Ethics of Life: Contemporary Iberian Debates

Ethics of Life

Contemporary Iberian Debates

Katarzyna Beilin

Vanderbilt University Press, 2016

The contributors ask the following questions:

• What are the different rhetorical strategies employed by writers, artists, filmmakers, and activists to react to the degradation of life and climate change?
• How are urban movements using environmental issues to resist corporate privatization of the commons?
• What is the shape of Spanish debates on reproductive rights and biotechnology?
• What is the symbolic significance of the bullfighting debate and other human/animal issues in today's political turmoil in Spain?

Hispanic Issues Series
Nicholas Spadaccini, Editor-in-Chief

Hispanic Issues Online
hispanicissues.umn.edu/online_main.html
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cover of Fighting for the Future of Food: Activists versus Agribusiness in the Struggle over Biotechnology

Fighting for the Future of Food

Activists versus Agribusiness in the Struggle over Biotechnology

Rachel Schurman

University of Minnesota Press, 2010

When scientists working in the agricultural biotechnology industry first altered the genetic material of one organism by introducing genes from an entirely different organism, the reaction was generally enthusiastic. To many, these genetically modified organisms (GMOs) promised to solve the challenges faced by farmers and to relieve world hunger. Yet within a decade, this "gene revolution" had abruptly stalled. Widespread protests against the potential dangers of "Frankenfoods" and the patenting of seed supplies in the developing world forced the industry to change course. As a result, in the late 1990s, some of the world's largest firms reduced their investment in the agricultural sector, narrowed their focus to a few select crops, or sold off their agricultural divisions altogether.

Fighting for the Future of Food tells the story of how a small group of social activists, working together across tables, continents, and the Internet, took on the biotech industry and achieved stunning success. Rachel Schurman and William A. Munro detail how the anti-biotech movement managed to alter public perceptions about GMOs and close markets to such products. Drawing strength from an alternative worldview that sustained its members' sense of urgency and commitment, the anti-GMO movement exploited political opportunities created by the organization and culture of the biotechnology industry itself.

Fighting for the Future of Food ultimately addresses society's understanding and trust (or mistrust) of technological innovation and the complexities of the global agricultural system that provides our food.
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cover of First the Seed: The Political Economy of Plant Biotechnology

First the Seed

The Political Economy of Plant Biotechnology

Jack Ralph Kloppenburg, Jr.

University of Wisconsin Press, 2005

First the Seed spotlights the history of plant breeding and shows how efforts to control the seed have shaped the emergence of the agricultural biotechnology industry. This second edition of a classic work in the political economy of science includes an extensive, new chapter updating the analysis to include the most recent developments in the struggle over the direction of crop genetic engineering.

1988 Cloth, 1990 Paperback, Cambridge University Press
Winner of the Theodore Saloutos Award of the Agricultural History Society
Winner of the Robert K. Merton Award of the American Sociological Association
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cover of Food for the Few: Neoliberal Globalism and Biotechnology in Latin America

Food for the Few

Neoliberal Globalism and Biotechnology in Latin America

Edited by Gerardo Otero

University of Texas Press, 2008

Recent decades have seen tremendous changes in Latin America's agricultural sector, resulting from a broad program of liberalization instigated under pressure from the United States, the IMF, and the World Bank. Tariffs have been lifted, agricultural markets have been opened and privatized, land reform policies have been restricted or eliminated, and the perspective has shifted radically toward exportation rather than toward the goal of feeding local citizens. Examining the impact of these transformations, the contributors to Food for the Few: Neoliberal Globalism and Biotechnology in Latin America paint a somber portrait, describing local peasant farmers who have been made responsible for protecting impossibly vast areas of biodiversity, or are forced to specialize in one genetically modified crop, or who become low-wage workers within a capitalized farm complex. Using dozens of examples such as these, the deleterious consequences are surveyed from the perspectives of experts in diverse fields, including anthropology, economics, geography, political science, and sociology.

From Kathy McAfee's "Exporting Crop Biotechnology: The Myth of Molecular Miracles," to Liz Fitting's "Importing Corn, Exporting Labor: The Neoliberal Corn Regime, GMOs, and the Erosion of Mexican Biodiversity," Food for the Few balances disturbing findings with hopeful assessments of emerging grassroots alternatives. Surveying not only the Latin American conditions that led to bankruptcy for countless farmers but also the North's practices, such as the heavy subsidies implemented to protect North American farmers, these essays represent a comprehensive, keenly informed response to a pivotal global crisis.

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cover of Fungible Life: Experiment in the Asian City of Life

Fungible Life

Experiment in the Asian City of Life

Aihwa Ong

Duke University Press, 2016

In Fungible Life Aihwa Ong explores the dynamic world of cutting-edge bioscience research, offering critical insights into the complex ways Asian bioscientific worlds and cosmopolitan sciences are entangled in a tropical environment brimming with the threat of emergent diseases. At biomedical centers in Singapore and China scientists map genetic variants, disease risks, and biomarkers, mobilizing ethnicized "Asian" bodies and health data for genomic research. Their differentiation between Chinese, Indian, and Malay DNA makes fungible Singapore's ethnic-stratified databases that come to "represent" majority populations in Asia. By deploying genomic science as a public good, researchers reconfigure the relationships between objects, peoples, and spaces, thus rendering "Asia" itself as a shifting entity. In Ong's analysis, Asia emerges as a richly layered mode of entanglements, where the population's genetic pasts, anxieties and hopes, shared genetic weaknesses, and embattled genetic futures intersect. Furthermore, her illustration of the contrasting methods and goals of the Biopolis biomedical center in Singapore and BGI Genomics in China raises questions about the future direction of cosmopolitan science in Asia and beyond.
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cover of Genentech: The Beginnings of Biotech

Genentech

The Beginnings of Biotech

Sally Smith Hughes

University of Chicago Press, 2011

In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise.
 
Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits.
 
Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.  
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cover of Genes in Development: Re-reading the Molecular Paradigm

Genes in Development

Re-reading the Molecular Paradigm

Eva M. Neumann-Held and Christoph Rehmann-Sutter, eds.

Duke University Press, 2006

In light of scientific advances such as genomics, predictive diagnostics, genetically engineered agriculture, nuclear transfer cloning, and the manipulation of stem cells, the idea that genes carry predetermined molecular programs or blueprints is pervasive. Yet new scientific discoveries—such as rna transcripts of single genes that can lead to the production of different compounds from the same pieces of dna—challenge the concept of the gene alone as the dominant factor in biological development. Increasingly aware of the tension between certain empirical results and interpretations of those results based on the orthodox view of genetic determinism, a growing number of scientists urge a rethinking of what a gene is and how it works. In this collection, a group of internationally renowned scientists present some prominent alternative approaches to understanding the role of dna in the construction and function of biological organisms.

Contributors discuss alternatives to the programmatic view of dna, including the developmental systems approach, methodical culturalism, the molecular process concept of the gene, the hermeneutic theory of description, and process structuralist biology. None of the approaches cast doubt on the notion that dna is tremendously important to biological life on earth; rather, contributors examine different ideas of how dna should be represented, evaluated, and explained. Just as ideas about genetic codes have reached far beyond the realm of science, the reconceptualizations of genetic theory in this volume have broad implications for ethics, philosophy, and the social sciences.

Contributors. Thomas Bürglin, Brian C. Goodwin, James Griesemer, Paul Griffiths, Jesper Hoffmeyer, Evelyn Fox Keller, Gerd B. Müller, Eva M. Neumann-Held, Stuart A. Newman, Susan Oyama, Christoph Rehmann-Sutter, Sahotra Sarkar, Jackie Leach Scully, Gerry Webster, Ulrich Wolf

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cover of Genomes and What to Make of Them

Genomes and What to Make of Them

Barry Barnes and John Dupré

University of Chicago Press, 2008

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it.

For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics­, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens. 

Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.
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cover of Intellectual Property: Trade, Competition, and Sustainable Development The World Trade Forum, Volume 3

Intellectual Property

Trade, Competition, and Sustainable Development The World Trade Forum, Volume 3

Thomas Cottier and Petros C. Mavroidis, Editors

University of Michigan Press, 2003

The incorporation of intellectual property protection into the WTO international trading system has been a milestone in international economic law and has added a new dimension to trade regulation — new rights and obligations and new challenges alike. The contributors, leading scholars and practitioners in the field, provide insights into the legal relationship of the TRIPs Agreement to the GATT 94 and the GATS. The book widens the debate with a thorough discussion on pending and unresolved relations of TRIPs, the WTO, UPOV, the Convention on Biodiversity and Farmers' Rights contained in the FAO International Undertaking, and efforts of the World Bank GCIAR system, including IPGRI. What will be the impact of TRIPs on ownership of plant genetic resources?
Largely a victory for OECD countries, the present state of intellectual property rights has important implications for developing countries. The incorporation of intellectual property rights into the WTO system will eventually change the relationship of trade, competition, and intellectual property. It will equally have to assist in providing equitable sharing of benefits in the use of plant genetic resources. All of these issues are essential for the revision of exclusions from patenting in TRIPs. This volume offers insights into how this difficult task could and should be approached in a balanced manner and will be essential reading for economists and trade and intellectual property lawyers interested in the subject. Moreover, the volume will be relevant to agricultural economists as it addresses complex problems in the interstices of trade, intellectual property, plant genetic resources, and sustainable development.
Thomas Cottier is Professor of European and International Economic Law, University of Bern, and Managing Director, World Trade Institute, University of Bern.
Petros C. Mavroidis is Professor of Law, University of Neuchâtel. He formerly worked in the Legal Affairs Division of the World Trade Organization.
Marion Panizzon is Research Fellow, University of Bern.
Simon Lacey is Research Fellow, University of Bern.
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cover of Kellogg on Biotechnology: Thriving through Integration

Kellogg on Biotechnology

Thriving through Integration

Alicia Loffler

Northwestern University Press, 2005

Biotechnology is the new capital. The stakeholders in this revolution are many: the scientists who generate the knowledge in fields where the pace is maddeningly fast; the technologists who make ideas a reality; the managers who struggle to deal with an industry where the old rules of thinking do not always apply; the venture capitalists who provide funds based on market moods rather than science; the health care, agricultural, chemical, and pharmaceutical industries whose once cozy enclaves have been revolutionized and are now barely recognizable; the law professionals and ethicists who have to grapple with issues unimaginable just a few years ago; the public policy makers who struggle with the complex issues and have to make decisions quickly, or risk being left behind; and, finally, the society and individuals who are in the midst of all that is taking place. This book addresses this diverse constituency and offers an integrated view of exciting new biotechnologies, both from a science and business perspective.

The book walks the reader through the "what"--what are some of the newest biotechnologies that will revolutionize the way we think about health?; the "how"--how to transform those technologies into profitable products and companies; and the "who"--who will benefit from these technologies?

Kellogg on Biotech is the outgrowth of a collaborative student-faculty effort called TechVentures at the Kellogg School of Management. Their research forms the raw material for Kellogg on Biotech.
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cover of Legitimating Life: Adoption in the Age of Globalization and Biotechnology

Legitimating Life

Adoption in the Age of Globalization and Biotechnology

van Wichelen, Sonja

Rutgers University Press, 2019

The phenomenon of transnational adoption is changing in the age of globalization and biotechnology. In Legitimating Life, Sonja van Wichelen boldly describes how contemporary justifications of cross-border adoption navigate between child welfare, humanitarianism, family making, capitalism, science, and health. Focusing on contemporary institutional practices of adoption in the United States and the Netherlands, she traces how professionals, bureaucrats, lawyers, politicians, social workers, and experts legitimate a practice that became progressively controversial. Throughout the past few decades transnational adoption transformed from a humanitarian response to a means of making family. In this new manifestation, life becomes necessarily economized. While push and pull factors, demand and supply dynamics, and competition between agencies set the stage for the globalization of adoption, international conventions, scientific knowledge, and the language of human rights universalized the phenomenon. Van Wichelen argues that such technoscientific legitimations of a globalizing practice are rearticulating colonial logics of race and civilization. Yet, she also lets us see beyond the biopolitical project and into alternative ways of making kin. 

 
 
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cover of Liminal Lives: Imagining the Human at the Frontiers of Biomedicine

Liminal Lives

Imagining the Human at the Frontiers of Biomedicine

Susan Merrill Squier

Duke University Press, 2004

Embryo adoptions, stem cells capable of transforming into any cell in the human body, intra- and inter-species organ transplantation—these and other biomedical advances have unsettled ideas of what it means to be human, of when life begins and ends. In the first study to consider the cultural impact of the medical transformation of the entire human life span, Susan Merrill Squier argues that fiction—particularly science fiction—serves as a space where worries about ethically and socially charged scientific procedures are worked through. Indeed, she demonstrates that in many instances fiction has anticipated and paved the way for far-reaching biomedical changes. Squier uses the anthropological concept of liminality—the state of being on the threshold of change, no longer one thing yet not quite another—to explore how, from the early twentieth century forward, fiction and science together have altered not only the concept of the human being but the contours of human life.

Drawing on archival materials of twentieth-century biology; little-known works of fiction and science fiction; and twentieth- and twenty-first century U.S. and U.K. government reports by the National Institutes of Health, the Parliamentary Advisory Group on the Ethics of Xenotransplantation, and the President’s Council on Bioethics, she examines a number of biomedical changes as each was portrayed by scientists, social scientists, and authors of fiction and poetry. Among the scientific developments she considers are the cultured cell, the hybrid embryo, the engineered intrauterine fetus, the child treated with human growth hormone, the process of organ transplantation, and the elderly person rejuvenated by hormone replacement therapy or other artificial means. Squier shows that in the midst of new phenomena such as these, literature helps us imagine new ways of living. It allows us to reflect on the possibilities and perils of our liminal lives.

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cover of Lively Capital: Biotechnologies, Ethics, and Governance in Global Markets

Lively Capital

Biotechnologies, Ethics, and Governance in Global Markets

Kaushik Sunder Rajan, ed.

Duke University Press, 2012

Lively Capital is an urgent and important collection of essays addressing the reconfigured relations between the life sciences and the market. Exploring the ground where social and cultural anthropology intersect with science and technology studies, prominent scholars investigate the relationship of biotechnology to ethics, governance, and markets, as well as the new legal, social, cultural, and institutional mechanisms emerging to regulate biotechnology. The contributors examine genomics, pharmaceutical marketing, intellectual property, environmental science, clinical trials, patient advocacy, and other such matters as they are playing out in North and South America, Europe, Africa, and Asia. Lively Capital is not only about the commercialization of the life sciences, but their institutional histories, epistemic formations, and systems of valuation. It is also about the lively affects—the emotions and desires—involved when technologies and research impinge on experiences of embodiment, kinship, identity, disability, citizenship, accumulation, and dispossession. At stake in the commodification of the life sciences are opportunities to intervene in and adjudicate matters of health, life, and death.

Contributors. Timothy Choy, Joseph Dumit, Michael M. J. Fischer, Kim Fortun, Mike Fortun, Donna Haraway, Sheila Jasanoff, Wen-Hua Kuo, Andrew Lakoff, Kristin Peterson, Chloe Silverman, Elta Smith, Kaushik Sunder Rajan, Travis J. Tanner

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cover of Making PCR: A Story of Biotechnology

Making PCR

A Story of Biotechnology

Paul Rabinow

University of Chicago Press, 1996

Making PCR is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time—the polymerase chain reaction. Transforming the practice and potential of molecular biology, PCR extends scientists' ability to identify and manipulate genetic materials and accurately reproduces millions of copies of a given segment in a short period of time. It makes abundant what was once scarce—the genetic material required for experimentation.

Making PCR explores the culture of biotechnology as it emerged at Certus Corporation during the 1980s and focuses on its distinctive configuration of scientific, technical, social, economic, political, and legal elements, each of which had its own separate trajectory over the preceding decade. The book contains interviews with the remarkable cast of characters who made PCR, including Kary Mullin, the maverick who received the Nobel prize for "discovering" it, as well as the team of young scientists and the company's business leaders.

This book shows how a contingently assembled practice emerged, composed of distinctive subjects, the site where they worked, and the object they invented.

"Paul Rabinow paints a . . . picture of the process of discovery in Making PCR: A Story of Biotechnology [and] teases out every possible detail. . . . Makes for an intriguing read that raises many questions about our understanding of the twisting process of discovery itself."—David Bradley, New Scientist

"Rabinow's book belongs to a burgeoning genre: ethnographic studies of what scientists actually do in the lab. . . . A bold move."—Daniel Zalewski, Lingua Franca

"[Making PCR is] exotic territory, biomedical research, explored. . . . Rabinow describes a dance: the immigration and repatriation of scientists to and from the academic and business worlds."—Nancy Maull, New York Times Book Review
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cover of Membranes to Molecular Machines: Active Matter and the Remaking of Life

Membranes to Molecular Machines

Active Matter and the Remaking of Life

Mathias Grote

University of Chicago Press, 2019

Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac.
 
Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher.

The research described in the book and its central actor, Dieter Oesterhelt, were honored with the 2021 Albert Lasker Basic Medical Research Award for his contribution to the development of optogenetics. The 2026 Nobel Prize in Physiology or Medicine was awarded to three scientists for discoveries leading to optogenetics. Membranes to Molecular Machines can be read as a prehistory of this research.
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cover of Mutant Ecologies: Manufacturing Life in the Age of Genomic Capital

Mutant Ecologies

Manufacturing Life in the Age of Genomic Capital

Erica Borg

Pluto Press, 2022

How capitalism is reconfiguring the very texture of life

Mutant Ecologies traces the spinning of new synthetic threads into the web of life. It is a critical cartography of the shifting landscapes of capital accumulation conjured by recent developments in genomic science, genome editing, and the biotech industry.

CRISPR crops, fast-growing salmons, heat-resistant Slick™ cows, Friendly™ Mosquitoes, humanized mice, pigs growing human organs – these are but a few of the dazzling new life-forms that have recently emerged from corporate and university laboratories around the world, all promising to lubricate the circuits of capital accumulation in distinct ways. The deliberate induction of genetic mutations is increasingly central to business operations in a number of sectors, from agriculture to pharmaceuticals.

While the Nobel Committee recently proclaimed the life sciences to have entered 'a new epoch', the authors show how these technological innovations continue to operate within a socio-historical context defined by the iron rules of capitalist competition and exploitation. Capital no longer contents itself by simply appropriating the living bodies of plants and animals. It purposefully designs its internal metabolism, and in that way, it redesigns the countless living vectors that constitute the global biosphere. It is driving a biological revolution, which will ripple through the everyday lives of people everywhere.

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cover of Nanofibres in Drug Delivery

Nanofibres in Drug Delivery

Gareth R. Williams, Bahijja T. Raimi-Abraham, and C. J. Luo

University College London, 2018

In recent years, there has been an explosion of interest in the production of nanoscale fibers for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibers in drug delivery, and to explain to them how to prepare fibers in the laboratory. The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fiber production and explain briefly the theory behind them. They discuss the experimental implementation of fiber production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fiber production, and use examples from current literature to show how each particular type of fibers can be applied to drug delivery. They also consider how fiber production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.
 
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cover of Negotiating Pharmaceutical Uncertainty: Women's Agency in a South African HIV Prevention Trial

Negotiating Pharmaceutical Uncertainty

Women's Agency in a South African HIV Prevention Trial

Eirik Saethre

Vanderbilt University Press, 2017

Telling the story of a clinical trial testing an innovative gel designed to prevent women from contracting HIV, Negotiating Pharmaceutical Uncertainty provides new insight into the complex and contradictory relationship between medical researchers and their subjects. Although clinical trials attempt to control and monitor participants' bodies, Saethre and Stadler argue that the inherent uncertainty of medical testing can create unanticipated opportunities for women to exercise control over their health, sexuality, and social relationships. Combining a critical analysis of the social production of biomedical knowledge and technologies with a detailed ethnography of the lives of female South African trial participants, this book brings to light issues of economic exclusion, racial disparity, and spiritual insecurity in Johannesburg's townships. Built on a series of tales ranging from strategy sessions at the National Institutes of Health to witchcraft accusations against the trial, Negotiating Pharmaceutical Uncertainty illuminates the everyday social lives of clinical trials.

As embedded anthropologists, Saethre and Stadler provide a unique and nuanced perspective of the reality of a clinical trial that is often hidden from view.
[more]
cover of Patent Politics: Life Forms, Markets, and the Public Interest in the United States and Europe

Patent Politics

Life Forms, Markets, and the Public Interest in the United States and Europe

Shobita Parthasarathy

University of Chicago Press, 2017

Over the past thirty years, the world’s patent systems have experienced pressure from civil society like never before. From farmers to patient advocates, new voices are arguing that patents impact public health, economic inequality, morality—and democracy. These challenges, to domains that we usually consider technical and legal, may seem surprising. But in Patent Politics, Shobita Parthasarathy argues that patent systems have always been deeply political and social.
 
To demonstrate this, Parthasarathy takes readers through a particularly fierce and prolonged set of controversies over patents on life forms linked to important advances in biology and agriculture and potentially life-saving medicines. Comparing battles over patents on animals, human embryonic stem cells, human genes, and plants in the United States and Europe, she shows how political culture, ideology, and history shape patent system politics. Clashes over whose voices and which values matter in the patent system, as well as what counts as knowledge and whose expertise is important, look quite different in these two places. And through these debates, the United States and Europe are developing very different approaches to patent and innovation governance. Not just the first comprehensive look at the controversies swirling around biotechnology patents, Patent Politics is also the first in-depth analysis of the political underpinnings and implications of modern patent systems, and provides a timely analysis of how we can reform these systems around the world to maximize the public interest.
[more]
cover of Playing God?: Human Genetic Engineering and the Rationalization of Public Bioethical Debate

Playing God?

Human Genetic Engineering and the Rationalization of Public Bioethical Debate

John H. Evans

University of Chicago Press, 2001

Technology evolves at a dazzling speed, and nowhere more so than in the field of genetic engineering, where the possibility of directly changing the genes of one's children is quickly becoming a reality. The public is rightly concerned, but interestingly, they have not had much to say about the implications of recent advancements in human genetics.

Playing God? asks why and explores the social forces that have led to the thinning out of public debate over human genetic engineering. John H. Evans contends that the problem lies in the structure of the debate itself. Disputes over human genetic engineering concern the means for achieving assumed ends, rather than being a healthy discussion about the ends themselves. According to Evans, this change in focus occurred as the jurisdiction over the debate shifted from scientists to bioethicists, a change which itself was caused by the rise of the bureaucratic state as the authority in such matters. The implications of this timely study are twofold. Evans not only explores how decisions about the ethics of human genetic engineering are made, but also shows how the structure of the debate has led to the technological choices we now face.
[more]
cover of Re-Creating Nature: Science, Technology, and Human Values in the Twenty-First Century

Re-Creating Nature

Science, Technology, and Human Values in the Twenty-First Century

James T. Bradley

University of Alabama Press, 2019

An exploration of the moral and ethical implications of new biotechnologies

Many of the ethical issues raised by new technologies have not been widely examined, discussed, or indeed settled. For example, robotics technology challenges the notion of personhood. Should a robot, capable of making what humans would call ethical decisions, be held responsible for those decisions and the resultant actions? Should society reward and punish robots in the same way that it does humans? Likewise, issues of safety, environmental concerns, and distributive justice arise with the increasing acceptance of genetically modified organisms (GMOs) in food production nanotechnology in engineering and medicine, and human gene therapy and enhancement. The problem of dual-use—when a technology can be used both to benefit and to harm—exists with virtually all new technologies but is central in the context of emerging 21st century technologies ranging from artificial intelligence and robotics to human gene-editing and brain-computer interfacing.

In Re-Creating Nature: Science, Technology, and Human Values in the Twenty-First Century, James T. Bradley addresses emerging biotechnologies with prodigious potential to benefit humankind but that are also fraught with ethical consequences. Some actually possess the power to directly alter the evolution of life on earth including human. Specifically, these topics include stem cells, synthetic biology, GMOs in agriculture, nanotechnology, bioterrorism, CRISPR gene-editing technology, three-parent babies, robotics and roboethics, artificial intelligence, and human brain research and neurotechnologies.

Offering clear explanations of these various technologies, a pragmatic presentation of the conundrums involved, and questions that illuminate hypothetical situations, Bradley guides discussions of these and other thorny issues resulting from the development of new biotechnologies. He also highlights the responsibilities of scientists to conduct research in an ethical manner and the responsibilities of nonscientists to become “science literate” in the twenty-first century.
[more]
cover of Reasons of Conscience: The Bioethics Debate in Germany

Reasons of Conscience

The Bioethics Debate in Germany

Stefan Sperling

University of Chicago Press, 2013

The implicit questions that inevitably underlie German bioethics are the same ones that have pervaded all of German public life for decades: How could the Holocaust have happened? And how can Germans make sure that it will never happen again? In Reasons of Conscience, Stefan Sperling considers the bioethical debates surrounding embryonic stem cell research in Germany at the turn of the twenty-first century, highlighting how the country’s ongoing struggle to come to terms with its past informs the decisions it makes today.
           
Sperling brings the reader unmatched access to the offices of the German parliament to convey the role that morality and ethics play in contemporary Germany. He describes the separate and interactive workings of the two bodies assigned to shape German bioethics—the parliamentary Enquiry Commission on Law and Ethics in Modern Medicine and the executive branch’s National Ethics Council—tracing each institution’s genesis, projected image, and operations, and revealing that the content of bioethics cannot be separated from the workings of these institutions. Sperling then focuses his discussion around three core categories—transparency, conscience, and Germany itself—arguing that without fully considering these, we fail to understand German bioethics. He concludes with an assessment of German legislators and regulators’ attempts to incorporate criteria of ethical research into the German Stem Cell Law.
[more]
cover of Representations of the Post/Human: Monsters, Aliens, and Others in Popular Culture

Representations of the Post/Human

Monsters, Aliens, and Others in Popular Culture

Graham, Elaine L.

Rutgers University Press, 2002

Microchips. Genetic modification of plants. Cloning. Advances in technology promise to shape our lives more profoundly than ever before. Exciting new discoveries in reproductive, genetic, and information technologies all serve to call into question the immutability of the boundaries between humans, animals, and machines. The category of the “posthuman” reflects the implications of such new technologies on contemporary culture, especially in their capacity to reconfigure the human body and to challenge our most fundamental understandings of human nature.

Elaine L. Graham explores these issues as they are expressed within popular culture and the creative arts. From the myth of Prometheus and the Gothic horror of Frankenstein’s monster to contemporary postmodern science fiction, a gallery of fantastic creatures haunts Western myth, religion, and literature. They serve to connect contemporary debates with enduring concerns about the potential—and the limits—of human creativity.

This book breaks new ground in drawing together a wide range of literature on new technologies and their ethical implications. In her explorations of the monstrous and the cyborg, Graham covers the Jewish legend of the golem, the Human Genome Project, Star Trek: Next Generation, Star Trek: Voyager, Fritz Lang’s Metropolis, Donna Haraway’s cyborg writing, andmany other related topics. This book will interest students in cultural studies, literature, ethics, religion, information technology, and the life sciences.

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cover of Reproductive Labor and Innovation: Against the Tech Fix in an Era of Hype

Reproductive Labor and Innovation

Against the Tech Fix in an Era of Hype

Jennifer Denbow

Duke University Press, 2024

In Reproductive Labor and Innovation, Jennifer Denbow examines how the push toward technoscientific innovation in contemporary American life often comes at the expense of the care work and reproductive labor that is necessary for society to function. Noting that the gutting of social welfare programs has shifted the burden of solving problems to individuals, Denbow argues that the aggrandizement of innovation and the degradation of reproductive labor are intertwined facets of neoliberalism. She shows that the construction of innovation as a panacea to social ills justifies the accumulation of wealth for corporate innovators and the impoverishment of those feminized and racialized people who do the bulk of reproductive labor. Moreover, even innovative technology aimed at reproduction—such as digital care work platforms and noninvasive prenatal testing—obscure structural injustices and further devalue reproductive labor. By drawing connections between innovation discourse, the rise of neoliberalism, financialized capitalism, and the social and political degradation of reproductive labor, Denbow illustrates what needs to be done to destabilize the overvaluation of innovation and to offer collective support for reproduction.
[more]
cover of Seeds of Occupation, Seeds of Possibility: The Agrochemical-GMO Industry in Hawai‘i

Seeds of Occupation, Seeds of Possibility

The Agrochemical-GMO Industry in Hawai‘i

Andrea Noelani Brower

West Virginia University Press, 2022

How Hawaiʻi became the epicenter of the biotech seed industry, and how a resistance movement arose to confront the industry’s power.

Hawaiʻi is a primary site for development of herbicide-resistant corn seed and, until recently, was host to more experimental field trials of genetically engineered crops than anywhere else in the world. It is also a node of powerful resistance. While documentaries and popular news stories have profiled the biotech seed industry in Hawaiʻi, Seeds of Occupation, Seeds of Possibility is the first book to detail the social and historical conditions by which the chemical-seed oligopoly came to occupy the most geographically isolated islands in the world and made the soils of Hawaiʻi the epicenter of agrochemical and agricultural biotechnology testing.

Andrea Brower, an activist-scholar from Hawaiʻi, examines the consequences related to genetically engineered seed development for Hawaiʻi’s people and the social movement that has risen in response. With insights beyond the islands, Seeds of Occupation, Seeds of Possibility illuminates why visions for a radically better world must be expanded by intersectional and systemically oriented movements.
 
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cover of Shaping Science and Technology Policy: The Next Generation of Research

Shaping Science and Technology Policy

The Next Generation of Research

Edited by David H. Guston and Daniel Sarewitz

University of Wisconsin Press, 2006

With scientific progress occurring at a breathtaking pace, science and technology policy has never been more important than it is today. Yet there is a very real lack of public discourse about policy-making, and government involvement in science remains shrouded in both mystery and misunderstanding.  Who is making choices about technology policy, and who stands to win or lose from these choices?  What criteria are being used to make decisions and why?  Does government involvement help or hinder scientific research?  

Shaping Science and Technology Policy brings together an exciting and diverse group of emerging scholars, both practitioners and academic experts, to investigate current issues in science and technology policy.  Essays explore such topics as globalization, the shifting boundary between public and private, informed consent in human participation in scientific research, intellectual property and university science, and the distribution of the costs and benefits of research. 

Contributors: Charlotte Augst, Grant Black, Mark Brown, Kevin Elliott, Patrick Feng, Pamela M. Franklin, Carolyn Gideon, Tené N. Hamilton, Brian A. Jackson, Shobita Parthasarathy, Jason W. Patton, A. Abigail Payne, Bhaven Sampat, Christian Sandvig, Sheryl Winston Smith, Michael Whong-Barr

[more]
cover of Synthetic: How Life Got Made

Synthetic

How Life Got Made

Sophia Roosth

University of Chicago Press, 2017

In the final years of the twentieth century, émigrés from engineering and computer science devoted themselves to biology and resolved that if the aim of biology is to understand life, then making life would yield better theories than experimentation. Armed with the latest biotechnology techniques, these scientists treated biological media as elements for design and manufacture: viruses named for computers, bacterial genomes encoding passages from James Joyce, chimeric yeast buckling under the metabolic strain of genes harvested from wormwood, petunias, and microbes from Icelandic thermal pools.
 
In Synthetic: How Life Got Made, cultural anthropologist Sophia Roosth reveals how synthetic biologists make new living things in order to understand better how life works. The first book-length ethnographic study of this discipline, Synthetic documents the social, cultural, rhetorical, economic, and imaginative transformations biology has undergone in the post-genomic age. Roosth traces this new science from its origins at MIT to start-ups, laboratories, conferences, and hackers’ garages across the United States—even to contemporary efforts to resurrect extinct species. Her careful research reveals that rather than opening up a limitless new field, these biologists’ own experimental tactics circularly determine the biological features, theories, and limits they fasten upon. Exploring the life sciences emblematic of our time, Synthetic tells the origin story of the astonishing claim that biological making fosters biological knowing.
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cover of The Cuban Cure: Reason and Resistance in Global Science

The Cuban Cure

Reason and Resistance in Global Science

S. M. Reid-Henry

University of Chicago Press, 2010

After Fidel Castro came to power in 1959, his second declaration, after socialism, was that Cuba would become a leader in international science. In biotechnology he would be proven right and, today, Cuba counts a meningitis B vaccine and cutting-edge cancer therapies to its name. But how did this politically and geographically isolated country make such impressive advances? Drawing on a unique ethnography, and blending the insights of anthropology, sociology, and geography, The Cuban Cure shows how Cuba came to compete with U. S. pharmaceutical giants—despite a trade embargo and crippling national debt.

            In uncovering what is distinct about Cuban biomedical science, S. M. Reid-Henry examines the forms of resistance that biotechnology research in Cuba presents to the globalization of western models of scientific culture and practice. He illustrates the epistemic, social, and ideological clashes that take place when two cultures of research meet, and how such interactions develop as political and economic circumstances change. Through a novel argument about the intersection of socioeconomic systems and the nature of innovation, The Cuban Cure presents an illuminating study of politics and science in the context of globalization.

[more]
cover of The Origins of Theoretical Population Genetics: With a New Afterword

The Origins of Theoretical Population Genetics

With a New Afterword

William B. Provine

University of Chicago Press, 2001

Tracing the development of population genetics through the writings of such luminaries as Darwin, Galton, Pearson, Fisher, Haldane, and Wright, William B. Provine sheds light on this complex field as well as its bearing on other branches of biology.
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cover of The Other Dark Matter: The Science and Business of Turning Waste into Wealth and Health

The Other Dark Matter

The Science and Business of Turning Waste into Wealth and Health

Lina Zeldovich

University of Chicago Press, 2021

Grossly ambitious and rooted in scientific scholarship, The Other Dark Matter shows how human excrement can be a life-saving, money-making resource—if we make better use of it.

The average person produces about four hundred pounds of excrement a year. More than seven billion people live on this planet. Holy crap!

Because of the diseases it spreads, we have learned to distance ourselves from our waste, but the long line of engineering marvels we’ve created to do so—from Roman sewage systems and medieval latrines to the immense, computerized treatment plants we use today—has also done considerable damage to the earth’s ecology. Now scientists tell us: we’ve been wasting our waste. When recycled correctly, this resource, cheap and widely available, can be converted into a sustainable energy source, act as an organic fertilizer, provide effective medicinal therapy for antibiotic-resistant bacterial infection, and much more.

In clear and engaging prose that draws on her extensive research and interviews, Lina Zeldovich documents the massive redistribution of nutrients and sanitation inequities across the globe. She profiles the pioneers of poop upcycling, from startups in African villages to innovators in American cities that convert sewage into fertilizer, biogas, crude oil, and even life-saving medicine. She breaks taboos surrounding sewage disposal and shows how hygienic waste repurposing can help battle climate change, reduce acid rain, and eliminate toxic algal blooms. Ultimately, she implores us to use our innate organic power for the greater good. Don’t just sit there and let it go to waste.
[more]
cover of The Recombinant University: Genetic Engineering and the Emergence of Stanford Biotechnology

The Recombinant University

Genetic Engineering and the Emergence of Stanford Biotechnology

Doogab Yi

University of Chicago Press, 2015

The advent of recombinant DNA technology in the 1970s was a key moment in the history of both biotechnology and the commercialization of academic research. Doogab Yi’s The Recombinant University draws us deeply into the academic community in the San Francisco Bay Area, where the technology was developed and adopted as the first major commercial technology for genetic engineering. In doing so, it reveals how research patronage, market forces, and legal developments from the late 1960s through the early 1980s influenced the evolution of the technology and reshaped the moral and scientific life of biomedical researchers.

Bay Area scientists, university administrators, and government officials were fascinated by and increasingly engaged in the economic and political opportunities associated with the privatization of academic research. Yi uncovers how the attempts made by Stanford scientists and administrators to demonstrate the relevance of academic research were increasingly mediated by capitalistic conceptions of knowledge, medical innovation, and the public interest. Their interventions resulted in legal shifts and moral realignments that encouraged the privatization of academic research for public benefit. The Recombinant University brings to life the hybrid origin story of  biotechnology and the ways the academic culture of science has changed in tandem with the early commercialization of recombinant DNA technology.
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cover of Transformed States: Medicine, Biotechnology, and American Culture, 1990–2020

Transformed States

Medicine, Biotechnology, and American Culture, 1990–2020

Martin Halliwell

Rutgers University Press, 2025

Honourable Mention, British Association of American Studies Book Award 

Transformed States offers a timely history of the politics, ethics, medical applications, and cultural representations of the biotechnological revolution, from the Human Genome Project to the COVID-19 pandemic. In exploring the entanglements of mental and physical health in an age of biotechnology, it views the post–Cold War 1990s as the horizon for understanding the intersection of technoscience and culture in the early twenty-first century.
 
The book draws on original research spanning the presidencies of George H. W. Bush and Joe Biden to show how the politics of science and technology shape the medical uses of biotechnology. Some of these technologies reveal fierce ideological conflicts in the arenas of cloning, reproduction, artificial intelligence, longevity, gender affirmation, vaccination and environmental health. Interweaving politics and culture, the book illustrates how these health issues are reflected in and challenged by literary and cinematic texts, from Oryx and Crake to Annihilation, and from Gattaca to Avatar.
 
By assessing the complex relationship between federal politics and the biomedical industry, Transformed States develops an ecological approach to public health that moves beyond tensions between state governance and private enterprise. To that end, Martin Halliwell analyzes thirty years that radically transformed American science, medicine, and policy, positioning biotechnology in dialogue with fears and fantasies about an emerging future in which health is ever more contested.
 
Along with the two earlier books, Therapeutic Revolutions (2013) and Voices of Mental Health (2017), Transformed States is the final volume of a landmark cultural and intellectual history of mental health in the United States, journeying from the combat zones of World War II to the global emergency of COVID-19.
 
[more]
cover of VAS: An Opera in Flatland: A Novel. By Steve Tomasula. Art and Design by Stephen Farrell.

VAS

An Opera in Flatland: A Novel. By Steve Tomasula. Art and Design by Stephen Farrell.

Steve Tomasula and Stephen Farrell

University of Chicago Press, 2004

Printed in the colors of flesh and blood, VAS: An Opera in Flatland—a hybrid image-text novel—demonstrates how differing ways of imagining the body generate diverse stories of history, gender, politics, and, ultimately, the literature of who we are.

A constantly surprising, VAS combines a variety of voices, from journalism and libretto to poem and comic book. Often these voices meet in counterpoint, and the meaning of the narrative emerges from their juxtapositions, harmonies, or discords. Utilizing a wide and historical sweep of representations of the body—from pedigree charts to genetic sequences—VAS is, finally, the story of finding one's identity within the double helix of language and lineage.
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