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Distinguished expert in vaccine development John Rhodes tells the story of the first approved COVID-19 vaccines and offers an essential, up-to-the-minute primer on how scientists discover, test, and distribute vaccines.

As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been—when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time.  In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment—and will lead to multiple COVID-19 vaccines.

Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won’t be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans.

As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.
 

In 2014 Barbados introduced a vaccine to prevent certain strains of the human papillomavirus (HPV) and reduce the risk of cervical cancer in young women. Despite the disproportionate burden of cervical cancer in the Caribbean, many Afro-Barbadians chose not to immunize their daughters. In Suspicion, Nicole Charles reframes Afro-Barbadian vaccine refusal from a question of hesitancy to one of suspicion. Drawing on ethnographic fieldwork, black feminist theory, transnational feminist studies and science and technology studies, Charles foregrounds Afro-Barbadians' gut feelings and emotions and the lingering trauma of colonial and biopolitical violence. She shows that suspicion, far from being irrational, is a fraught and generative affective orientation grounded in concrete histories of mistrust of government and coercive medical practices foisted on colonized peoples. By contextualizing suspicion within these longer cultural and political histories, Charles troubles traditional narratives of vaccine hesitancy while offering new entry points into discussions on racialized biopolitics, neocolonialism, care, affect, and biomedicine across the Black diaspora.

Duke University Press Scholars of Color First Book Award recipient

The Salk vaccine seemed like a miracle to parents whose children were threatened with the scourge of polio. With its protection from polio, came also a story line-there were heroic researchers who would use science to protect us from epidemics and perhaps even eradicate disease. For most people, vaccines have become the magic bullets for dealing with dangerous diseases. The continuing quest for new vaccines, including an HIV/AIDS vaccine, despite technical, epidemiological, and social obstacles, suggests the abiding power of this narrative.

The author examines four cases that span the twentieth century--diphtheria, rubella, pertussis, and HIV/AIDS. Each case challenges the reader to examine how the values we attribute to vaccines influence their use. Diphtheria vaccination brought laboratory science into an existing narrative based on earlier vaccines. With rubella vaccine, researchers efficiently responded to an epidemic of birth defects while subtly changing the relationship between vaccination recipients and beneficiaries. Opposition to pertussis vaccine from average Americans created a narrative crisis, in which faith in vaccination as a whole seemed to be at risk. With more recent vaccines, including a hoped-for HIV/AIDS vaccine, the persistent cultural narrative continues to encourage vaccine development and use.