Results by title
7 books match the query 'Virology'
A Contagious Cause
The American Hunt for Cancer Viruses and the Rise of Molecular MedicineRobin Wolfe Scheffler
University of Chicago Press, 2019
Is cancer a contagious disease? In the late nineteenth century this idea, and attending efforts to identify a cancer “germ,” inspired fear and ignited controversy. Yet speculation that cancer might be contagious also contained a kernel of hope that the strategies used against infectious diseases, especially vaccination, might be able to subdue this dread disease. Today, nearly one in six cancers are thought to have an infectious cause, but the path to that understanding was twisting and turbulent.
A Contagious Cause is the first book to trace the century-long hunt for a human cancer virus in America, an effort whose scale exceeded that of the Human Genome Project. The government’s campaign merged the worlds of molecular biology, public health, and military planning in the name of translating laboratory discoveries into useful medical therapies. However, its expansion into biomedical research sparked fierce conflict. Many biologists dismissed the suggestion that research should be planned and the idea of curing cancer by a vaccine or any other means as unrealistic, if not dangerous. Although the American hunt was ultimately fruitless, this effort nonetheless profoundly shaped our understanding of life at its most fundamental levels. A Contagious Cause links laboratory and legislature as has rarely been done before, creating a new chapter in the histories of science and American politics.
A Contagious Cause is the first book to trace the century-long hunt for a human cancer virus in America, an effort whose scale exceeded that of the Human Genome Project. The government’s campaign merged the worlds of molecular biology, public health, and military planning in the name of translating laboratory discoveries into useful medical therapies. However, its expansion into biomedical research sparked fierce conflict. Many biologists dismissed the suggestion that research should be planned and the idea of curing cancer by a vaccine or any other means as unrealistic, if not dangerous. Although the American hunt was ultimately fruitless, this effort nonetheless profoundly shaped our understanding of life at its most fundamental levels. A Contagious Cause links laboratory and legislature as has rarely been done before, creating a new chapter in the histories of science and American politics.
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A Planet of Viruses
Second EditionCarl Zimmer
University of Chicago Press, 2015
For years, scientists have been warning us that a pandemic was all but inevitable. Now it's here, and the rest of us have a lot to learn.
Fortunately, science writer Carl Zimmer is here to guide us. In this compact volume, he tells the story of how the smallest living things known to science can bring an entire planet of people to a halt--and what we can learn from how we've defeated them in the past.
Planet of Viruses covers such threats as Ebola, MERS, and chikungunya virus; tells about recent scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and shares new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and, for all its honesty about the threats, as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a world we all need to better understand.
Fortunately, science writer Carl Zimmer is here to guide us. In this compact volume, he tells the story of how the smallest living things known to science can bring an entire planet of people to a halt--and what we can learn from how we've defeated them in the past.
Planet of Viruses covers such threats as Ebola, MERS, and chikungunya virus; tells about recent scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and shares new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and, for all its honesty about the threats, as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a world we all need to better understand.
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A Planet of Viruses
Third EditionCarl Zimmer
University of Chicago Press, 2021
In 2020, an invisible germ—a virus—wholly upended our lives. We’re most familiar with the viruses that give us colds or Covid-19. But viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in deep caves miles underground.
Fully revised and updated, with new illustrations and a new chapter about coronaviruses and the spread of Covid-19, this third edition of Carl Zimmer’s A Planet of Viruses pulls back the veil on this hidden world. It presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate as long as life endures.
Fully revised and updated, with new illustrations and a new chapter about coronaviruses and the spread of Covid-19, this third edition of Carl Zimmer’s A Planet of Viruses pulls back the veil on this hidden world. It presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate as long as life endures.
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How to Make a Vaccine
An Essential Guide for COVID-19 and BeyondJohn Rhodes
University of Chicago Press, 2021
Distinguished expert in vaccine development John Rhodes tells the story of the first approved COVID-19 vaccines and offers an essential, up-to-the-minute primer on how scientists discover, test, and distribute vaccines.
As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been—when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time. In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment—and will lead to multiple COVID-19 vaccines.
Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won’t be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans.
As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.
As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been—when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time. In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment—and will lead to multiple COVID-19 vaccines.
Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won’t be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans.
As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.
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The Elephant in the Room
How to Stop Making Ourselves and Other Animals SickLiz Kalaugher
University of Chicago Press, 2025
A healthier future starts with seeing the human causes of wildlife diseases.
When new diseases spread, news reports often focus on wildlife culprits—rodents, monkeys and mpox; bats and COVID-19; waterfowl and avian flu; or mosquitoes and Zika. But, in this urgent and engaging book, we see it often works the other way around—humans have caused diseases in other animals countless times, through travel and transport, the changes we impose on our environment, and global warming. With science journalist Liz Kalaugher as our guide, we meet the wildlife we have harmed and the experts now studying the crosscurrents between humans, other animals, and health.
Herds of buffalo in Kenya, cloned ferrets in Colorado, and frogs shipped worldwide as living pregnancy tests for humans, all help Kalaugher dive into the murky backstories behind wildlife epidemics past and present. We learn that military conflict likely contributed to the spread of rinderpest, or cattle plague, throughout Africa, devastating pastoral communities. That crowded poultry farms may create virulent new forms of bird flu that spill back into the wild. And that West Nile virus—which affects not only birds and humans, but other animals, including horses, skunks, and squirrels—is spreading as global temperatures rise.
Expanding today’s discussions of environmental protection to include illness and its impact, Kalaugher both sounds the alarm and explores ways to stop the emergence and spread of wildlife diseases. These solutions start with a simple lesson: when we protect other animals, we protect ourselves.
When new diseases spread, news reports often focus on wildlife culprits—rodents, monkeys and mpox; bats and COVID-19; waterfowl and avian flu; or mosquitoes and Zika. But, in this urgent and engaging book, we see it often works the other way around—humans have caused diseases in other animals countless times, through travel and transport, the changes we impose on our environment, and global warming. With science journalist Liz Kalaugher as our guide, we meet the wildlife we have harmed and the experts now studying the crosscurrents between humans, other animals, and health.
Herds of buffalo in Kenya, cloned ferrets in Colorado, and frogs shipped worldwide as living pregnancy tests for humans, all help Kalaugher dive into the murky backstories behind wildlife epidemics past and present. We learn that military conflict likely contributed to the spread of rinderpest, or cattle plague, throughout Africa, devastating pastoral communities. That crowded poultry farms may create virulent new forms of bird flu that spill back into the wild. And that West Nile virus—which affects not only birds and humans, but other animals, including horses, skunks, and squirrels—is spreading as global temperatures rise.
Expanding today’s discussions of environmental protection to include illness and its impact, Kalaugher both sounds the alarm and explores ways to stop the emergence and spread of wildlife diseases. These solutions start with a simple lesson: when we protect other animals, we protect ourselves.
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The Life of a Virus
Tobacco Mosaic Virus as an Experimental Model, 1930-1965Angela N. H. Creager
University of Chicago Press, 2001
We normally think of viruses in terms of the devastating diseases they cause, from smallpox to AIDS. But in The Life of a Virus, Angela N. H. Creager introduces us to a plant virus that has taught us much of what we know about all viruses, including the lethal ones, and that also played a crucial role in the development of molecular biology.
Focusing on the tobacco mosaic virus (TMV) research conducted in Nobel laureate Wendell Stanley's lab, Creager argues that TMV served as a model system for virology and molecular biology, much as the fruit fly and laboratory mouse have for genetics and cancer research. She examines how the experimental techniques and instruments Stanley and his colleagues developed for studying TMV were generalized not just to other labs working on TMV, but also to research on other diseases such as poliomyelitis and influenza and to studies of genes and cell organelles. The great success of research on TMV also helped justify increased spending on biomedical research in the postwar years (partly through the National Foundation for Infantile Paralysis's March of Dimes)—a funding priority that has continued to this day.
Focusing on the tobacco mosaic virus (TMV) research conducted in Nobel laureate Wendell Stanley's lab, Creager argues that TMV served as a model system for virology and molecular biology, much as the fruit fly and laboratory mouse have for genetics and cancer research. She examines how the experimental techniques and instruments Stanley and his colleagues developed for studying TMV were generalized not just to other labs working on TMV, but also to research on other diseases such as poliomyelitis and influenza and to studies of genes and cell organelles. The great success of research on TMV also helped justify increased spending on biomedical research in the postwar years (partly through the National Foundation for Infantile Paralysis's March of Dimes)—a funding priority that has continued to this day.
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Virus Research in Twentieth-Century Uganda
Between Local and GlobalJulia Ross Cummiskey
Ohio University Press, 2024
Virus Research in Twentieth-Century Uganda presents the stories of scientists at the Uganda Virus Research Institute (UVRI), a biomedical center founded in 1936. The book analyzes the strategies and conditions that allowed the institute to endure and thrive through successive political and scientific regimes of the interwar period, the postwar period, the transition to independence, the conflicts of the 1970s and 1980s, and the Museveni presidency. Julia Ross Cummiskey combines methods and themes from the history of medicine and public health, science and technology studies, and African studies to show that the story of the UVRI and the people who worked there transforms our understanding of the nature of local and international expertise and the evolution of global health research over the course of the twentieth century.
Global health is one of the chief areas in which African and foreign institutions interact today. Billions of dollars are invested in global health projects on the continent, many involving strategically selected “local partners.” In the discourse of these projects, local and global are often framed as complementary but distinct categories of people, institutions, traditions, and practices. But the history of biomedical research at the UVRI shows that these distinctions are unstable and mutable and that people and institutions have mobilized both categories to attract funding, professional prestige, and research opportunities. The book complicates the local/global binary that is implicit (and sometimes explicit) in many studies of colonial, international, and global health and medical research, especially in Africa. Moreover, it challenges assumptions about global health as an enterprise dominated by researchers based in the Global North and recenters the history of biomedicine in Africa.
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