Both theory and animal experiments often relate impairment of fertility and fetal development to the stress of hypoxia. This comprehensive, penetrating study includes critical reviews of theory and experiments as well as of previous studies of human birth weight and neonatal mortality at high altitudes in the United States. It also reports on studies of mothers, placentas, and the newborn in two Peruvian populations, one in the Andes, the other at sea level. It presents new evidence on the functional significance of various aspects of placental anatomy and on racial differences in maternal ability to nourish the fetus at high altitudes.

Innumerable clinical problems have as their basis some derangement in oxygen-dependent metabolism. To explore mechanisms of adjusting to oxygen limitation, Living without Oxygen presents a bestiary of exotic anaerobes that illuminate elements of metabolic biochemistry only dimly seen in studies using standard experimental animals. With their exaggerated anaerobic capabilities, Hochachka's diving mammals, airbreathing fishes, and hypoxia-adapted lower vertebrates allow a detailed assessment of what can and what cannot be adjusted in the process of extending hypoxia tolerance. The book places the enzymatic and biochemical machinery firmly in the biological context and assumes only a modest familiarity with bioenergetics and metabolic biochemistry. The author's clear prose should make this technical presentation pleasantly unintimidating for any physiologist, biochemist, or clinical investigator. The insights of his unique approach make Living without Oxygen essential reading.