Beginning with the discovery of genes on chromosomes and culminating with the unmasking of the most minute genetic mysteries, the twentieth century saw astounding and unprecedented progress in the science of biology. In an illustrious career that spanned most of the century, biologist John Bonner witnessed many of these advances firsthand. Part autobiography, part history of the extraordinary transformation of biology in his time, Bonner’s book is truly a life in science, the story of what it is to be a biologist observing the unfolding of the intricacies of life itself.

Bonner’s scientific interests are nearly as varied as the concerns of biology, ranging from animal culture to evolution, from life cycles to the development of slime molds. And the extraordinary cast of characters he introduces is equally diverse, among them Julian Huxley, J. B. S. Haldane, Leon Trotsky, and Evelyn Waugh. Writing with a charm and freshness that bring the most subtle nuances of science to life, he pursues these interests through the hundred years that gave us the discovery of embryonic induction; the interpretation of evolution in terms of changes in gene frequency in a population; growth in understanding of the biochemistry of the cell; the beginning of molecular genetics; remarkable insights into animal behavior; the emergence of sociobiology; and the simplification of ecological and evolutionary principles by means of mathematical models. In this panoramic view, we see both the sweep of world events and scientific progress and the animating details, the personal observations and experiences, of a career conducted in their midst.

In Bonner’s view, biology is essentially the study of life cycles. His book, marking the cycles of a life in biology, is a fitting reflection of this study, with its infinite, and infinitesimal, permutations.

On Development is, as John Tyler Bonner says, “a book on ideas,” the ideas at stake in the contest to unravel the mechanisms of life. This fluent discussion of developmental biology synthesizes decades of intensive progress in specialized areas of the science: from the dramatic deciphering of the genetic code to detailed analyses of animal behavior patterns. Placing these discoveries in an evolutionary context, Bonner explores the continuities and the transitoriness of individual lives and individual forms.

He begins by discussing the ubiquity among organisms of developmental cycles and their universal properties, including senescence and death. He argues that the life cycle itself is an object of natural selection and shows how, in any species, it reflects the evolutionary tradeoff between energy requirements of the individual and reproductive efficiency of the species. Although nucleic acids are thought to be the ultimate and fundamental source of genetic regulation, Bonner points out that a massive amount of information required for normal development is not directly controlled by nuclear DNA during the life cycle. Each life cycle is governed by some immediate instructions from the genes and by many gene-initiated instructions that were given in previous life cycles and have accumulated in various parts of the fertilized egg. All of these instructions taken together govern the development of a new organism.

Acknowledging the great value of reductionist theories in biology, Bonner constructs his synthetic view of development without resorting to vitalist concepts or to hand-waving explanations. He draws examples and evidence from more than half a century of biological research, from sources as diverse as Spemann and Spiegelman. Certain organisms, such as the cellular slime molds, upon which Bonner himself has conducted a number of original experiments, and the social insects provide crucial examples of dramatic evolutionary increments in biological complexity and offer insight into the control mechanisms that make such advances possible.