Too tiny to see with the naked eye, the human embryo was just a hypothesis until the microscope made observation of embryonic development possible. This changed forever our view of the minuscule cluster of cells that looms large in questions about the meaning of life. Embryos under the Microscope examines how our scientific understanding of the embryo has evolved from the earliest speculations of natural philosophers to today’s biological engineering, with its many prospects for life-enhancing therapies. Jane Maienschein shows that research on embryos has always revealed possibilities that appear promising to some but deeply frightening to others, and she makes a persuasive case that public understanding must be informed by up-to-date scientific findings.

Direct observation of embryos greatly expanded knowledge but also led to disagreements over what investigators were seeing. Biologists confirmed that embryos are living organisms undergoing rapid change and are not in any sense functioning persons. They do not feel pain or have any capacity to think until very late stages of fetal development. New information about DNA led to discoveries about embryonic regulation of genetic inheritance, as well as evolutionary relationships among species. Scientists have learned how to manipulate embryos in the lab, taking them apart, reconstructing them, and even synthesizing—practically from scratch—cells, body parts, and maybe someday entire embryos. Showing how we have learned what we now know about the biology of embryos, Maienschein changes our view of what it means to be alive.

Explorations in Developmental Biology is a revolutionary departure from time-honored introductory texts. The book is based on the premise that the substance, concepts, and excitement of contemporary developmental biology are best communicated to students by using the same form in which they were first communicated to the scientific community — original research reports. But a simple collection of original papers is not sufficient; it is too limited in scope and too disjointed, and students are not prepared to read them with understanding. In this book, designed to serve as the principal text for a first or second course in developmental biology, basic concepts are presented in a series of 22 chapters that focus on major, often unsolved, problems ranging from self-assembly to embryonic induction to cellular communication by surface contact. Within each chapter the authors provide the necessary background in developmental biology, and also describe the specific experimental procedures that enable the student to understand and appreciate the contributions of significant research papers that are included. The authors' texts and the reprinted papers are integrated into a cohesive whole, so that each chapter provides up-to-date information about an important area of developmental biology and raises specific questions.

Throughout, the text is profusely illustrated with original drawings and with figures taken from the literature, and each chapter contains a brief guide to pertinent publications.

Explorations in Developmental Biology makes it possible for teachers and students to penetrate the perennial barrier between classroom and research laboratory. Students who use this book are well equipped to move on to more advanced studies in biology; for they will have acquired the ability to use and to evaluate original scientific communications and will have assimilated the subject matter of a science that is at the center of modern biology.

All humans share three origins: the beginning of our individual lives, the appearance of life on Earth, and the formation of our planetary home. Life through Time and Space brings together the latest discoveries in both biology and astronomy to examine our deepest questions about where we came from, where we are going, and whether we are alone in the cosmos.

A distinctive voice in the growing field of astrobiology, Wallace Arthur combines embryological, evolutionary, and cosmological perspectives to tell the story of life on Earth and its potential to exist elsewhere in the universe. He guides us on a journey through the myriad events that started with the big bang and led to the universe we inhabit today. Along the way, readers learn about the evolution of life from a primordial soup of organic molecules to complex plants and animals, about Earth’s geological transformation from barren rock to diverse ecosystems, and about human development from embryo to infant to adult. Arthur looks closely at the history of mass extinctions and the prospects for humanity’s future on our precious planet.

Do intelligent aliens exist on a distant planet in the Milky Way, sharing the three origins that characterize all life on Earth? In addressing this question, Life through Time and Space tackles the many riddles of our place and fate in the universe that have intrigued human beings since they first gazed in wonder at the nighttime sky.

What do biologists want? If, unlike their counterparts in physics, biologists are generally wary of a grand, overarching theory, at what kinds of explanation do biologists aim? How will we know when we have “made sense” of life? Such questions, Evelyn Fox Keller suggests, offer no simple answers. Explanations in the biological sciences are typically provisional and partial, judged by criteria as heterogeneous as their subject matter. It is Keller’s aim in this bold and challenging book to account for this epistemological diversity—particularly in the discipline of developmental biology.

In particular, Keller asks, what counts as an “explanation” of biological development in individual organisms? Her inquiry ranges from physical and mathematical models to more familiar explanatory metaphors to the dramatic contributions of recent technological developments, especially in imaging, recombinant DNA, and computer modeling and simulations.

A history of the diverse and changing nature of biological explanation in a particularly charged field, Making Sense of Life draws our attention to the temporal, disciplinary, and cultural components of what biologists mean, and what they understand, when they propose to explain life.

On Development is, as John Tyler Bonner says, “a book on ideas,” the ideas at stake in the contest to unravel the mechanisms of life. This fluent discussion of developmental biology synthesizes decades of intensive progress in specialized areas of the science: from the dramatic deciphering of the genetic code to detailed analyses of animal behavior patterns. Placing these discoveries in an evolutionary context, Bonner explores the continuities and the transitoriness of individual lives and individual forms.

He begins by discussing the ubiquity among organisms of developmental cycles and their universal properties, including senescence and death. He argues that the life cycle itself is an object of natural selection and shows how, in any species, it reflects the evolutionary tradeoff between energy requirements of the individual and reproductive efficiency of the species. Although nucleic acids are thought to be the ultimate and fundamental source of genetic regulation, Bonner points out that a massive amount of information required for normal development is not directly controlled by nuclear DNA during the life cycle. Each life cycle is governed by some immediate instructions from the genes and by many gene-initiated instructions that were given in previous life cycles and have accumulated in various parts of the fertilized egg. All of these instructions taken together govern the development of a new organism.

Acknowledging the great value of reductionist theories in biology, Bonner constructs his synthetic view of development without resorting to vitalist concepts or to hand-waving explanations. He draws examples and evidence from more than half a century of biological research, from sources as diverse as Spemann and Spiegelman. Certain organisms, such as the cellular slime molds, upon which Bonner himself has conducted a number of original experiments, and the social insects provide crucial examples of dramatic evolutionary increments in biological complexity and offer insight into the control mechanisms that make such advances possible.

A Marginal Revolution Book of the Year

After tracking the lives of thousands of people from birth to midlife, four of the world’s preeminent psychologists reveal what they have learned about how humans develop.

Does temperament in childhood predict adult personality? What role do parents play in shaping how a child matures? Is day care bad—or good—for children? Does adolescent delinquency forecast a life of crime? Do genes influence success in life? Is health in adulthood shaped by childhood experiences? In search of answers to these and similar questions, four leading psychologists have spent their careers studying thousands of people, observing them as they’ve grown up and grown older. The result is unprecedented insight into what makes each of us who we are.

In The Origins of You, Jay Belsky, Avshalom Caspi, Terrie Moffitt, and Richie Poulton share what they have learned about childhood, adolescence, and adulthood, about genes and parenting, and about vulnerability, resilience, and success. The evidence shows that human development is not subject to ironclad laws but instead is a matter of possibilities and probabilities—multiple forces that together determine the direction a life will take. A child’s early years do predict who they will become later in life, but they do so imperfectly. For example, genes and troubled families both play a role in violent male behavior, and, though health and heredity sometimes go hand in hand, childhood adversity and severe bullying in adolescence can affect even physical well-being in midlife.

Painstaking and revelatory, the discoveries in The Origins of You promise to help schools, parents, and all people foster well-being and ameliorate or prevent developmental problems.

One of our most brilliant evolutionary biologists, Richard Lewontin has also been a leading critic of those—scientists and non-scientists alike—who would misuse the science to which he has contributed so much. In The Triple Helix, Lewontin the scientist and Lewontin the critic come together to provide a concise, accessible account of what his work has taught him about biology and about its relevance to human affairs. In the process, he exposes some of the common and troubling misconceptions that misdirect and stall our understanding of biology and evolution.

The central message of this book is that we will never fully understand living things if we continue to think of genes, organisms, and environments as separate entities, each with its distinct role to play in the history and operation of organic processes. Here Lewontin shows that an organism is a unique consequence of both genes and environment, of both internal and external features. Rejecting the notion that genes determine the organism, which then adapts to the environment, he explains that organisms, influenced in their development by their circumstances, in turn create, modify, and choose the environment in which they live.

The Triple Helix is vintage Lewontin: brilliant, eloquent, passionate, and deeply critical. But it is neither a manifesto for a radical new methodology nor a brief for a new theory. It is instead a primer on the complexity of biological processes, a reminder to all of us that living things are never as simple as they may seem.