BiblioVault - Books about Limulus polyphemus

William Sargent

University Press of New England

Surviving almost unmolested for 300 million years, the horseshoe crab is now the object of an intense legal and ethical struggle involving marine biologists, environmentalists, US government officials, biotechnologists, and international corporations. The source of this friction is the discovery 25 years ago that the blood of these ancient creatures serves as the basis for the most reliable test for the deadly and ubiquitous gram-negative bacteria. These bacteria are responsible for life-threatening diseases like menengitis, typhoid, E. coli, Legionnaire’s Disease and toxic shock syndrome. Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion dollar industry has emerged involving the license to “bleed” horseshoe crabs and the rights to their breeding grounds. Since his youthful fascination with these ancient creatures, William Sargent has spent much of his life observing, studying, and collecting horseshoe crabs. As a result, he presents a thoroughly accessible insider’s guide to the discovery of the lysate test, the exploitation of the crabs at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures’ ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource.

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The American Horseshoe Crab

Carl N. Shuster Jr.

Harvard University Press, 2003

The American horseshoe crab that comes ashore on the East Coast in vast numbers to mate and nest is much the same creature that haunted the coast before the time of the dinosaurs. It is among the world's most intensely studied marine invertebrates, critical to our understanding of many groups of organisms, both modern and extinct, and crucial to the ecology of large estuaries such as the Delaware Bay. Some stocks of this great survivor, whose ancestors made it through the mass extinction some 286 million years ago, have been severely depleted today because of overfishing and habitat destruction.

Carl N. Shuster, Jr., H. Jane Brockmann, and Robert B. Barlow are at the forefront of research on Limulus polyphemus, and in this book they bring together twenty scientists who have worked on all aspects of horseshoe crab biology to compile the first fully detailed, comprehensive view of the species. An indispensable resource, the volume describes the horseshoe crab's behavior, natural history, and ecology; its anatomy, physiology, distribution, development, and life cycle; the puzzle of its immune system; and its present management and future conservation.

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Crab Wars

A Tale of Horseshoe Crabs, Ecology, and Human Health

William Sargent

Brandeis University Press, 2021

A timely look at the exploitation of a species that has helped with the development of countless drugs and is fast becoming endangered.

Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion-dollar industry has emerged involving the license to bleed horseshoe crabs and the rights to their breeding grounds. William Sargent presents a thoroughly accessible insider’s guide to the discovery of the lysate test, the exploitation of the horseshoe crab at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures’ ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource. This new edition brings the story up to date as companies race to manufacture alternatives to the horseshoe crab blood, which is now essential for testing vaccines such as those developed to counter COVID-19. However, horseshoe crab populations are still dwindling, with profound implications not only for the future of the crabs themselves but also for the ecosystems that depend on them.

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