“Bold and intriguing.”—Wall Street Journal • “Penetrating. . . . Provocative and profound.”—Publishers Weekly (starred review) • “Offers plenty of food for thought.”—Kirkus Reviews (starred review)
 
“Ball’s marvelous book is both wide-ranging and deep. . . . I could not put it down.”—Siddhartha Mukherjee, author of The Song of the Cell and the Pulitzer Prize–winning The Emperor of All Maladies

A cutting-edge new vision of biology that will revise our concept of what life itself is, how to enhance it, and what possibilities it offers.
 
Biology is undergoing a quiet but profound transformation. Several aspects of the standard picture of how life works—the idea of the genome as a blueprint, of genes as instructions for building an organism, of proteins as precisely tailored molecular machines, of cells as entities with fixed identities, and more—have been exposed as incomplete, misleading, or wrong.
 
In How Life Works, Philip Ball explores the new biology, revealing life to be a far richer, more ingenious affair than we had guessed. Ball explains that there is no unique place to look for an answer to this question: life is a system of many levels—genes, proteins, cells, tissues, and body modules such as the immune system and the nervous system—each with its own rules and principles. How Life Works explains how these levels operate, interface, and work together (most of the time).
 
With this knowledge come new possibilities. Today we can redesign and reconfigure living systems, tissues, and organisms. We can reprogram cells, for instance, to carry out new tasks and grow into structures not seen in the natural world. As we discover the conditions that dictate the forms into which cells organize themselves, our ability to guide and select the outcomes becomes ever more extraordinary. Some researchers believe that ultimately we will be able to regenerate limbs and organs, and perhaps even create new life forms that evolution has never imagined.
 
Incorporating the latest research and insights, How Life Works is a sweeping journey into this new frontier of the life sciences, a realm that will reshape our understanding of life as we know it.

In this accessible analysis, a philosopher and a science educator look at biological theory and society through a synthesis of mechanistic and organicist points of view to best understand the complexity of life and biological systems.

The search for a unified framework for biology is as old as Plato’s musings on natural order, which suggested that the universe itself is alive. But in the twentieth century, under the influence of genetics and microbiology, such organicist positions were largely set aside in favor of mechanical reductionism, by which life is explained by the movement of its parts. But can organisms truly be understood in mechanical terms, or do we need to view life from the perspective of whole organisms to make sense of biological complexity?

The New Biology argues for the validity of holistic treatments from the perspectives of philosophy, history, and biology and outlines the largely unrecognized undercurrent of organicism that has persisted. Mechanistic biology has been invaluable in understanding a range of biological issues, but Michael Reiss and Michael Ruse contend that reductionism alone cannot answer all our questions about life. Whether we are considering human health, ecology, or the relationship between sex and gender, we need to draw from both organicist and mechanistic frameworks.

It’s not always a matter of combining organicist and mechanistic perspectives, Reiss and Ruse argue. There is scope for a range of ways of understanding the complexity of life and biological systems. Organicist and mechanistic approaches are not simply hypotheses to be confirmed or refuted, but rather operate as metaphors for describing a universe of sublime intricacy.