For most people, a diagnosis of cystic fibrosis means the certainty of a life ended too soon. But for twin girls with the disease, what began as a family’s stubborn determination grew into a miracle.

            The tragedy of CF has been touchingly recounted in such books as Frank Deford’s Alex: The Life of a Child, but The Power of Two is the first book to portray the symbiotic relationship between twins who share this life-threatening disease through adulthood. Isabel Stenzel Byrnes and Anabel Stenzel tell of their lifelong struggle to pursue normal lives with cystic fibrosis while grappling with the realization that they will die young. Their story reflects the physical and emotional challenges of a particularly aggressive form of CF and tells how the twins’ bicultural heritage—Japanese and German—influenced the way they coped with these challenges.

            Born in 1972, seventeen years before scientists discovered the genetic mutation that causes CF, Isabel and Anabel endured the daily regimen of chest percussion, frequent doctor visits, and lengthy hospitalizations. But they tell how, in the face of innumerable setbacks, their deep-seated dependence on each other allowed them to survive long enough to reap the benefits of the miraculous lung transplants that marked a crossroads in their lives: “We have an old life—one of growing up with chronic illness—and a new life—one of opportunities and gifts we have never imagined before.” In this memoir, they pay tribute to the people who shaped their experience.

            The Power of Two is an honest and gripping portrayal of day-to-day health care, the impact of chronic illness on marriage and family, and the importance of a support network to continuing survival. It conveys an important message to both popular and professional readers as it addresses key psychosocial issues in chronic illness throughout the sufferer’s lifespan and illuminates the human side of advances in biotechnology.

            Even as gene therapy and stem cell research increase the chances for eradicating CF, this stirring account portrays its effects on one family that refused to give up. These two remarkable sisters have much to teach about the power of perseverance—and about the ultimate power of hope.

Denise Duhamel's much anticipated new collection begins with a revisionist tale--Noah is married to Joan of Arc--in a poem about America's often flawed sense of history. Throughout Two and Two, doubles abound: Noah's animals; Duhamel's parents as Jack and Jill in a near-fatal accident; an incestuous double sestina; a male/female pantoum; a dream and its interpretation; and translations of advertisements from English to Spanish. In two Möbius strip poems (shaped like the Twin Towers), Duhamel invites her readers to get out their scissors and tape and transform her poems into 3-D objects.

At the book's center is "Love Which Took Its Symmetry for Granted," a gathering of journal entries, personal e-mails, and news reports into a collage of witness about September 11. A section of "Mille et un sentiments," modeled on the lists of Hervé Le Tellier, Georges Perec, and George Brainard, breaks down emotions to their most basic levels, their 1,001 tiny recognitions. The book ends with "Carbó Frescos," written in the form of an art guidebook from the 24th century.

Innovative and unpretentious, Duhamel uses twice the language usually available for poetry. She culls from the literary and nonliterary, from the Bible and product warning labels, from Woody Allen films and Hong Kong action movies--to say difficult things with astonishing accuracy. Two and Two is second to none.

Contributors. Abolade Adeniji, John T. Chalcraft, Duane J. Corpis, Ian Christopher Fletcher, Yaël Simpson Fletcher, Matthew Guterl, Rafael M. Hernández, Vinay Lal, R. J. Lambrose, Mukoma wa Ngugi, Masao Nishikawa, Takamitsu Ono, Nalini Persaud, Alka Roy, Micol Seigel, Christine Skwiot, Karen Sotiropoulos, Ulrike Strasser, Vijaya Teelock, Heidi Tinsman, Jyotsna Uppal, Merry Wiesner-Hanks