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Plague and Pleasure is a lively popular history that introduces a new hypothesis about the impetus behind the cultural change in Renaissance Italy. The Renaissance coincided with a period of chronic, constantly recurring plague, unremitting warfare and pervasive insecurity. Consequently, people felt a need for mental escape to alternative, idealized realities, distant in time or space from the unendurable present but made vivid to the imagination through literature, art, and spectacle.

Aeneas Sylvius Piccolomini (1405-1464, elected Pope Pius II in 1458) was an important and enigmatic figure of the Renaissance as well as one of the most prolific writers and gifted stylists ever to occupy the papacy