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Blind since early childhood, the Egyptian theologian and monk Didymus (ca. 313-398) wielded a masterful knowledge of Scripture, philosophy, and previous biblical interpretation, earning the esteem of his contemporaries Athanasius, Antony of Egypt, Jerome, Rufinus, and Palladius, as well as of the historians Socrates and Theodoret in the decades following his death. He was, however, anathematized by the Fifth Ecumenical Council in 553 because of his utilization and defense of the works of Origen, and this condemnation may be responsible for the loss of many of Didymus's writings. Jerome and Palladius mentioned that Didymus had written commentaries on Old Testament books; these commentaries were assumed to be no longer extant until the discovery in 1941 in Tura, Egypt, of papyri containing commentaries on Genesis, Zechariah, Job, Ecclesiastes, and some of the Psalms.

A disciple of Origen, whose work on Zechariah reached only to chapter five and is no longer extant, Didymus's commentary on this apocalyptic book illustrates the typically allegorical approach to the biblical text that we associate with Alexandria