CMOS-based sensors offer significant advantages to life science applications, such as non-invasive long-term recordings, fast responses and label-free processes. They have been widely applied in many biological and medical fields for the study of living cell samples such as neural cell recording and stimulation, monitoring metabolic activity, cell manipulation, and extracellular pH monitoring. Compared to other sensing techniques, capacitive sensors are low-complexity, high-precision, label-free sensing methods for monitoring cellular activities such as cell viability, proliferation and morphology.

• Chapter 1: Introduction
• Chapter 2: Design, implementation, and characterization of CMOS capacitive biosensors
• Chapter 3: Microelectrodes
• Chapter 4: CMOS interface circuits of capacitive biosensors
• Chapter 5: Microfluidic packaging
• Chapter 6: Biological/chemical applications
• Chapter 7: Current technology and future work
• Appendix A: Simulation of electrodes
• Appendix B: Fabrication techniques
• Appendix C: Simulation of single-ended and fully differential core-CBCM CVCs
• Appendix D: Simulation of a core-CBCM CFC
• Appendix E: Cell culture