In his Foreword to this edition, Jean Charlot says: "An unusual feature of Orozco's letters is the great deal that he has to say about art. That one artist writing to another would emphasize art as his subject seems normal enough to the American reader. Yet, within the context of the Mexico of those days, the fact remains exceptional. The patria Orozco was leaving behind had, even from the point of view of its artists, many cares more pressing than art."

The letters and unpublished writings of Orozco from this period (1925-1929) describe an important period of transition in the artist's life, from his departure from Mexico, almost as a defeated man, to the period just before he received the great mural commissions—Pomona, The New School for Social Research in New York, Dartmouth—that were to bring him lasting international fame.

Between 1932 and 1934, José Clemente Orozco painted the twenty-four-panel mural cycle entitled The Epic of American Civilization in Dartmouth College's Baker-Berry Library. An artifact of Orozco's migration from Mexico to the United States, the Epic represents a turning point in his career, standing as the only fresco in which he explores both US-American and Mexican narratives of national history, progress, and identity. While his title invokes the heroic epic form, the mural indicts history as complicit in colonial violence. It questions the claims of Manifest Destiny in the United States and the Mexican desire to mend the wounds of conquest in pursuit of a postcolonial national project. In Orozco's American Epic Mary K. Coffey places Orozco in the context of his contemporaries, such as Diego Rivera and David Alfaro Siqueiros, and demonstrates the Epic's power as a melancholic critique of official indigenism, industrial progress, and Marxist messianism. In the process, Coffey finds within Orozco's work a call for justice that resonates with contemporary debates about race, immigration, borders, and nationality.