How did cells make the journey, one we take so much for granted, from their origin in living bodies to something that can be grown and manipulated on artificial media in the laboratory, a substantial biomass living outside a human body, plant, or animal? This is the question at the heart of Hannah Landecker's book. She shows how cell culture changed the way we think about such central questions of the human condition as individuality, hybridity, and even immortality and asks what it means that we can remove cells from the spatial and temporal constraints of the body and "harness them to human intention."

Rather than focus on single discrete biotechnologies and their stories--embryonic stem cells, transgenic animals--Landecker documents and explores the wider genre of technique behind artificial forms of cellular life. She traces the lab culture common to all those stories, asking where it came from and what it means to our understanding of life, technology, and the increasingly blurry boundary between them. The technical culture of cells has transformed the meaning of the term "biological," as life becomes disembodied, distributed widely in space and time. Once we have a more specific grasp on how altering biology changes what it is to be biological, Landecker argues, we may be more prepared to answer the social questions that biotechnology is raising.

Aging and cancer may be manifestations of genetic, or epigenetic, changes in somatic cells. Through research, laboratory analysis of these related processes has become possible. Cells can be removed from the body, kept warm in laboratory glassware, nourished by artificial solutions, and studied for years, or even decades. Two types of cultures have emerged: Primary cultures, grown from cells obtained directly from living animals, may grow well for generations, but ultimately cease to divide. Established cultures, on the other hand, may grow and divide indefinitely. It is a striking fact that most, if not all, established cultures consist of cells that are heteroploid, having an abnormal chromosome complement that may include structural rearrangements as well as abnormalities of chromosome number.

Most established cultures are also neoplastic on behavior and morphology—in this, they resemble cancers—and established cultures are, in fact, often grown from cancer cells. Interest in the role of chromosomes in neoplasia has recently been overshadowed by an emphasis on tumor viruses. This book should reawaken the former interest. It will also arouse new interest in the role of epigenetic mechanisms of animal cells, in contrast to the classic genetic processes. As Dr. John Littlefield writes: “The relationship between the overcoming of senescence, the appearance of heteroploidy, and the acquisition of neoplastic qualities is not yet clear, but it is of such great theoretical and practical importance as to demand attention and new ideas.”