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Adaptive Oncogenesis
A New Understanding of How Cancer Evolves inside Us
James DeGregori
Harvard University Press, 2018

Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer’s occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body’s tissues. His theory ties cancer’s progression, or lack thereof, to evolved strategies to maximize reproductive success.

Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes—but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells’ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species’ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells.

DeGregori’s perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues’ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

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Crafting Science
A Sociohistory of the Quest for the Genetics of Cancer
Joan H. Fujimura
Harvard University Press, 1996

During the late 1970s and 1980s, "cancer" underwent a remarkable transformation. In one short decade, what had long been a set of heterogeneous diseases marked by uncontrolled cell growth became a disease of our genes. How this happened and what it means is the story Joan Fujimura tells in a rare inside look at the way science works and knowledge is created. A dramatic study of a new species of scientific revolution, this book combines a detailed ethnography of scientific thought, an in-depth account of science practiced and produced, a history of one branch of science as it entered the limelight, and a view of the impact of new genetic technologies on science and society.

The scientific enterprise that Fujimura unfolds for us is proto-oncogene cancer research--the study of those segments of DNA now thought to make normal cells cancerous. Within this framework, she describes the processes of knowledge construction as a social enterprise, an endless series of negotiations in which theories, material technologies, and practices are co-constructed, incorporated, and refashioned. Along the way, Fujimura addresses long-standing questions in the history and philosophy of science, culture theory, and sociology of science: How do scientists create "good" problems, experiments, and solutions? What are the cultural, institutional, and material technologies that have to be in place for new truths and new practices to succeed?

Portraying the development of knowledge as a multidimensional process conducted through multiple cultures, institutions, actors, objects, and practices, this book disrupts divisions among sociology, history, anthropology, and the philosophy of science, technology, and medicine.

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Creating Born Criminals
Nicole Hahn Rafter
University of Illinois Press, 1997
Genetic screening, new reproductive technologies, gene therapies, and the reality of cloning all make biological solutions to human social problems seem possible. Creating Born Criminals shows how history can guide us in our response to the reemergence of eugenics. The first social history origins and content, showing their undue influence on crime control in the United States.
 
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Everyone Here Spoke Sign Language
Hereditary Deafness on Martha’s Vineyard
Nora Ellen Groce
Harvard University Press, 1985

From the seventeenth century to the early years of the twentieth, the population of Martha’s Vineyard manifested an extremely high rate of profound hereditary deafness. In stark contrast to the experience of most Deaf people in our own society, the Vineyarders who were born Deaf were so thoroughly integrated into the daily life of the community that they were not seen—and did not see themselves—as handicapped or as a group apart. Deaf people were included in all aspects of life, such as town politics, jobs, church affairs, and social life. How was this possible?

On the Vineyard, hearing and Deaf islanders alike grew up speaking sign language. This unique sociolinguistic adaptation meant that the usual barriers to communication between the hearing and the Deaf, which so isolate many Deaf people today, did not exist.

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Fitting the Facts of Crime
An Invitation to Biopsychosocial Criminology
Chad Posick, Michael Rocque, and J.C. Barnes
Temple University Press, 2022

Biosocial criminology—and biosocial criminologists—focuses on both the environmental and biological factors that contribute to antisocial behavior. Importantly, these two domains are not separate parts of an equation but pieces of the same puzzle that fit together for a complete picture of the causes of crime/antisocial behavior. 

Fitting the Facts of Crime applies a biopsychosocial lens to the “13 facts of crime” identified by John Braithwaite in his classic book, Crime, Shame and Reintegration. The authors unpack established facts—about gender and sex, age, environment, education, class, social bonds and associations, stress, and other influences—providing both empirical research and evidence from biopsychosocial criminology to address the etiology behind these facts and exactly how they are related to deviant behavior.

With their approach, the authors show how biopsychosocial criminology can be a unifying framework to enrich our understanding of the most robust and well-established topics in the field. In so doing, they demonstrate how biological and psychological findings can be responsibly combined with social theories to lend new insight into existing inquiries and solutions. Designed to become a standard text for criminology in general, Fitting the Facts of Crime introduces key concepts and applies them to real-world situations.

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Food, Genes, and Culture
Eating Right for Your Origins
Gary Paul Nabhan
Island Press, 2014

Vegan, low fat, low carb, slow carb: Every diet seems to promise a one-size-fits-all solution to health. But they ignore the diversity of human genes and how they interact with what we eat.

In Food, Genes, and Culture, renowned ethnobotanist Gary Nabhan shows why the perfect diet for one person could be disastrous for another. If your ancestors were herders in Northern Europe, milk might well provide you with important nutrients, whereas if you’re Native American, you have a higher likelihood of lactose intolerance. If your roots lie in the Greek islands, the acclaimed Mediterranean diet might save your heart; if not, all that olive oil could just give you stomach cramps.

Nabhan traces food traditions around the world, from Bali to Mexico, uncovering the links between ancestry and individual responses to food. The implications go well beyond personal taste. Today’s widespread mismatch between diet and genes is leading to serious health conditions, including a dramatic growth over the last 50 years in auto-immune and inflammatory diseases.

Readers will not only learn why diabetes is running rampant among indigenous peoples and heart disease has risen among those of northern European descent, but may find the path to their own perfect diet.


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Gangs on Trial
Challenging Stereotypes and Demonization in the Courts
John M. Hagedorn
Temple University Press, 2022

John Hagedorn, who has long been an expert witness in gang-related court cases, claims that what transpires in the trials of gang members is a far cry from what we would consider justice. In Gangs on Trial, he recounts his decades of experience to show how stereotypes are used against gang members on trial and why that is harmful. Hagedorn uses real-life stories to explain how implicit bias often replaces evidence and how the demonization of gang members undermines fairness. Moreover, a “them and us” mentality leads to snap judgments that ignore the complexity of gang life in America.

Gangs on Trial dispels myths about gangs and recommends tactics for lawyers, mitigation specialists, and expert witnesses as well as offering insights for jurors. Hagedorn describes how minds are subconsciously “primed” when a defendant is identified as a gang member, and discusses the “backfire effect,” which occurs when jurors hear arguments that run counter to their beliefs. He also reveals how attributional errors, prejudice, and racism impact sentences of nonwhite defendants.

Hagedorn argues that dehumanization is the psychological foundation of mass incarceration. Gangs on Trial advocates for practical sentencing reforms and humanizing justice.

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Genetics, Disability, and Deafness
John Vickrey Van Cleve
Gallaudet University Press, 2004

Pulitzer Prize-winning author Louis Menand begins this wide-ranging volume with an essay that extols diversity and warns of the dangers of modifying the human genome. Nora Groce reviews the ways that societies have defined disability and creates an interpretive framework for discussing the relationship between culture and disability.

     In essays devoted to historical perspective, Brian H. Greenwald comments upon the real “toll” taken by A. G. Bell’s insistence upon oralism, while Joseph J. Murray weighs the nineteenth-century debate over whether deaf-deaf marriages should be encouraged. John S. Schuchman’s chilling account of deafness and eugenics in the Nazi era adds wrenching reinforcement to the impetus to include disabled people in genetics debates.

     Mark Willis offers an intensely personal reflection on the complexities of genetic alteration, addressing both his heart condition and his blindness in surprisingly different ways. Anna Middleton extends Willis’s concepts in her discussion of couples currently considering the use of genetic knowledge and technology to select for or against a gene that causes deafness.

     In the part on the science of genetics, Orit Dagan, Karen B. Avraham, Kathleen S. Arnos, and Arti Pandya clarify the choices presented by genetic engineering, and geneticist Walter E. Nance emphasizes the importance of science in offering individuals knowledge from which they can fashion their own decisions. In the concluding section, Christopher Krentz raises moral questions about the ever-continuing search for human perfection, and Michael Bérubé argues that disability should be considered democratically to ensure full participation of disabled people in all decisions that might affect them.

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How Fat Works
Philip A. Wood
Harvard University Press, 2006
An experimental pathologist and molecular geneticist, Philip Wood uses gene-knockout technology to study the way mouse genes regulate the metabolism of fat—research that provides insights into the workings of fatty-acid metabolism in humans and what can happen when that metabolic balance goes awry. Based on the classes he regularly teaches to first- and second-year medical students, Wood's book reviews the individual and public health burden of obesity and clarifies often-used, but often inadequately explained, terms employed in the continuing cultural and scientific debate about excess fat. He explains the role of fat in the healthy body, how fat is made, stored, and burned, and demonstrates how excess fat can lead to an array of metabolic disorders and diseases, from hypercholesterolemia and insulin resistance to diabetes. He reviews what recent research can tell us about specific genes or groups of genes that can lead to specific metabolic disorders. He explains the science behind common weight-loss regimens and why those regimens might succeed or fail, and reviews the complex interplay of hormones, genes, and stress in the way our bodies deal with fat through the life cycle. How Fat Works is a concise, clear, and up-to-date primer on the workings of fat, and essential reading for professionals entering careers in medicine and public health administration or anyone wanting a better understanding of one of our most urgent health crises.
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Longevity, Senescence, and the Genome
Caleb E. Finch
University of Chicago Press, 1990
Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging.

To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.
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Of Maybugs and Men
A History and Philosophy of the Sciences of Homosexuality
Pieter R. Adriaens and Andreas De Block
University of Chicago Press, 2022
A much-needed exploration of the history and philosophy of scientific research into male homosexuality.

Questions about the naturalness or unnaturalness of homosexuality are as old as the hills, and the answers have often been used to condemn homosexuals, their behaviors, and their relationships. In the past two centuries, a number of sciences have involved themselves in this debate, introducing new vocabularies, theories, arguments, and data, many of which have gradually helped tip the balance toward tolerance and even acceptance. In this book, philosophers Pieter R. Adriaens and Andreas De Block explore the history and philosophy of the gay sciences, revealing how individual and societal values have colored how we think about homosexuality.

The authors unpack the entanglement of facts and values in studies of male homosexuality across the natural and human sciences and consider the extent to which science has mitigated or reinforced homonegative mores. The focus of the book is on homosexuality’s assumed naturalness. Geneticists rephrased naturalness as innateness, claiming that homosexuality is innate—colloquially, that homosexuals are born gay. Zoologists thought it a natural affair, documenting its existence in myriad animal species, from maybugs to men. Evolutionists presented homosexuality as the product of natural selection and speculated about its adaptive value. Finally, psychiatrists, who initially pathologized homosexuality, eventually appealed to its naturalness or innateness to normalize it. 

Discussing findings from an array of sciences—comparative zoology, psychiatry, anthropology, evolutionary biology, social psychology, developmental biology, and machine learning—this book is essential reading for anyone interested in what science has to say about homosexuality.
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Origins of Psychopathology
The Phylogenetic and Cultural Basis of Mental Illness
Fábrega Jr., Horacio
Rutgers University Press, 2002
What are the origins of human psychopathology? Is mental illness a relatively recent phenomenon, or has it been with us throughout evolution?

In Origins of Psychopathology, Horacio Fárega Jr. employs principles of evolutionary biology to better understand the significance of mental illness. He explores whether what psychiatry has categorized as mental disorders could have existed during earlier phases of human evolution. Fábrega approaches the prominent features of mental disorders as adaptive responses to the environment and life’s circumstances, which in turn can only be understood in the context of our evolutionary past. Taking his cue from theoretical issues raised by research into primate behavior and early hominid evolution, he poses the question: What, if any, aspects of mental illness are rooted in our evolution? Does mental illness occur in primates and other animals, and if so, what does this tell us about mental illness in human evolution? How has mental illness played an adaptive role? How has the development of language and higher cognitive functions affected characteristics of psychopathology?  Fábrega synthesizes insights from both the clinical and the evolutionary points of view. This facet of psychopathology, which involves its origins and manifestations viewed across the expanse of human evolution, has, until now, been largely neglected in psychiatric education, theory, and practice.
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Plant Resistance to Herbivores and Pathogens
Ecology, Evolution, and Genetics
Edited by Robert S. Fritz and Ellen L. Simms
University of Chicago Press, 1992
Far from being passive elements in the landscape, plants have developed many sophisticated chemical and mechanical means of deterring organisms that seek to prey on them. This volume draws together research from ecology, evolution, agronomy, and plant pathology to produce an ecological genetics perspective on plant resistance in both natural and agricultural systems. By emphasizing the ecological and evolutionary basis of resistance, the book makes an important contribution to the study of how phytophages and plants coevolve.

Plant Resistance to Herbivores and Pathogens not only reviews the literature pertaining to plant resistance from a number of traditionally separate fields but also examines significant questions that will drive future research. Among the topics explored are selection for resistance in plants and for virulence in phytophages; methods for studying natural variation in plant resistance; the factors that maintain intraspecific variation in resistance; and the ecological consequences of within-population genetic variation for herbivorous insects and fungal pathogens.

"A comprehensive review of the theory and information on a large, rapidly growing, and important subject."—Douglas J. Futuyma, State University of New York, Stony Brook
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Probably Someday Cancer
Genetic Risk and Preventative Mastectomy
Kim Horner
University of North Texas Press, 2019

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Sweetness in the Blood
Race, Risk, and Type 2 Diabetes
James Doucet-Battle
University of Minnesota Press, 2021

A bold new indictment of the racialization of science

Decades of data cannot be ignored: African American adults are far more likely to develop Type 2 diabetes than white adults. But has science gone so far in racializing diabetes as to undermine the search for solutions? In a rousing indictment of the idea that notions of biological race should drive scientific inquiry, Sweetness in the Blood provides an ethnographic picture of biotechnology’s framings of Type 2 diabetes risk and race and, importantly, offers a critical examination of the assumptions behind the recruitment of African American and African-descent populations for Type 2 diabetes research.

James Doucet-Battle begins with a historical overview of how diabetes has been researched and framed racially over the past century, chronicling one company’s efforts to recruit African Americans to test their new diabetes risk-score algorithm with the aim of increasing the clinical and market value of the firm’s technology. He considers African American reticence about participation in biomedical research and examines race and health disparities in light of advances in genomic sequencing technology. Doucet-Battle concludes by emphasizing that genomic research into sub-Saharan ancestry in fact underlines the importance of analyzing gender before attempting to understand the notion of race. No disease reveals this more than Type 2 diabetes.

Sweetness in the Blood challenges the notion that the best approach to understanding, managing, and curing Type 2 diabetes is through the lens of race. It also transforms how we think about sugar, filling a neglected gap between the sugar- and molasses-sweetened past of the enslaved African laborer and the high-fructose corn syrup- and corporate-fed body of the contemporary consumer-laborer.

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