Arousal is fundamental to all cognition. It is intuitively obvious, absolutely necessary, but what exactly is it? In Brain Arousal and Information Theory, Donald Pfaff presents a daring perspective on this long-standing puzzle. Pfaff argues that, beneath our mental functions and emotional dispositions, a primitive neuronal system governs arousal. Employing the simple but powerful framework of information theory, Pfaff revolutionizes our understanding of arousal systems in the brain.

Starting with a review of the neuroanatomical, neurophysiological, and neurochemical components of arousal, Pfaff asks us to look at the gene networks and neural pathways underlying the brain’s arousal systems much as a design engineer would contemplate information systems. This allows Pfaff to postulate that there is a bilaterally symmetric, bipolar system universal among mammals that readies the animal or the human being to respond to stimuli, initiate voluntary locomotion, and react to emotional challenges. Applying his hypothesis to heightened states of arousal—sex and fear—Pfaff shows us how his theory opens new scientific approaches to understanding the structure of brain arousal.

A major synthesis of disparate data by a preeminent neuroscientist, Brain Arousal and Information Theory challenges current thinking about cognition and behavior. Whether you subscribe to Pfaff’s theory or not, this book will stimulate debate about the nature of arousal itself.

Movement has long been considered the most obvious expression of brain activity and its correlative, mental activity. By studying movement, the neurophysiologist hopes to penetrate the interior of the living being and uncover the hidden source of action and its clues to the origin of life. We presume a role for the brain in movement—but should the brain be viewed simply as a machine that reacts to diverse stimuli, or is it an intelligent machine that organizes and controls not only itself but also the world around it?

Drawing upon the many disciplines that have contributed to brain research—anatomy, physiology, clinical neurology, psychology, psychiatry—Marc Jeannerod traces three centuries of ideas about movement and the brain. His critique of neural science takes into account the work of thinkers ranging from Descartes and Willis to Held, Hubel and Wiesel, Piaget and Chomsky. In his historical survey Jeannerod sees parallels between the influential neurological theories and dominating philosophical questions of the time: What is the nature of the soul? How does knowledge originate? What is the relation between the living organism and its milieu? Jeannerod's elegant arguments demonstrate that the “brain-movement problem” is the essential paradigm of the “brain-mind problem.” He advances a view of the neural organization of movement that has far-reaching implications for psychology and all neural sciences.

Throughout his remarkable career, Donald Pfaff has demonstrated that by choosing problems and methods with care, biologists can study the molecular mechanisms of brains more complex than those of fruit flies, snails, roundworms, and other invertebrates. His half century in the lab, starting with his discovery of hormone receptors in the brains of mammals and leading to the first detailed account of a neural circuit for mammalian behavior, puts him in a unique position to survey the origins and development of behavioral neurobiology and the current state of research. How the Vertebrate Brain Regulates Behavior offers a close-up, conversational perspective on scientific struggles and successes throughout a fifty-year quest to understand how behavior is regulated in a complex organism.

In graduate school, when Pfaff expressed a desire to study behavioral regulation, his advisor suggested focusing on hormones. Pfaff’s investigation into the hormonal basis of female sexual behavior in laboratory rats led him to a comprehensive appreciation of how hormone-dependent neurons work through neural circuits to produce discrete behaviors among all vertebrates. This breakthrough, along with other researchers’ findings, established a link between molecular biology and neuroscience that opened up a fruitful new field of inquiry.

Pfaff’s approach is to focus on one solvable problem and explore it from many angles. He begins with a single observed behavior and traces its regulation through a series of biological mechanisms—from hormones to genes to neural circuits. Pfaff’s relentless pursuit of his goals continues to inspire neuroscientists today.

If we are to understand the brain, we must understand how the individual molecules and cells of the nervous system function and ultimately contribute to our behavior. Molecular and Cellular Physiology of Neurons provides a comprehensive and up-to-date account of what we now know—and what we want to know and can reasonably expect to discover in the near future—about the functioning of the brain at the level of molecules and cells.

Molecular and Cellular Physiology of Neurons takes readers from the fundamentals to the most sophisticated concepts and latest discoveries: from membrane potentials to recent experiments on voltage-gated ion channels, from descriptions of receptors, G proteins, effector molecules, and second messengers to an account of our current understanding of long-term potentiation.

In each chapter Fain discusses individual experiments that have made crucial contributions to our knowledge and that illustrate the techniques and approaches that have formed our present view of nerve cell function. Extensive illustrations add to this vivid account of not only what we know about cellular and molecular neurophysiology but how we know it.

Harvard University Press is proud to announce the second edition of a widely admired introductory textbook. When first published, Neurons and Networks filled the need for an introductory neuroscience text that is lucid, accessible, authoritative, logically organized, and concise. Avoiding the encyclopedic coverage that makes most neuroscience texts overwhelming, Neurons and Networks focused instead on building the solid foundation of understanding and knowledge required for further study.

The new edition retains the features that made the first edition so attractive: consistent emphasis on results and concepts that have stood the test of time; abundant high-quality illustrations; exceptionally clear explanations of technical terms. Completely revised and enlarged with six new chapters, the second edition of Neurons and Networks is an introduction not just to neurobiology, but to all of behavioral neuroscience. It is an ideal text for first- or second-year college students with minimal college science exposure. It is also an invaluable resource for students in biology, psychology, anthropology, and computer science who seek an accessible guide to a discipline that will be a critically important area of research in the twenty-first century.