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In 2020, an invisible germ—a virus—wholly upended our lives. We’re most familiar with the viruses that give us colds or Covid-19. But viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in deep caves miles underground.
 
Fully revised and updated, with new illustrations and a new chapter about coronaviruses and the spread of Covid-19, this third edition of Carl Zimmer’s A Planet of Viruses pulls back the veil on this hidden world. It presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate as long as life endures.

Since the turn of the new millennium, ‘translational research’, the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe.  Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline’s most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in the hope of improving human health will find inspiration in examining the sacrifices and achievements of Cerami’s career in translational medicine. During his three decades at Rockefeller University his cross-disciplinary and laboratory-without-wall approach established ‘rational drug design’ as the most effective means of advancing the fields of parasitology, hematology, immunology, metabolism, therapeutics and molecular medicine. Cerami’s story and that of the evolution of translation are intimately entwined: the contours of Cerami’s career shaped by developments in translation, and in exchange, the field itself molded by Cerami’s work.  To understand one is to understand the other. By examining the life of this often overlooked biochemist it is possible to intimately focus on the ideas and thought processes of a scientist who has helped to define the great acceleration in translational research over the past half century – research that, knowingly or otherwise, has most likely affected the life of almost everyone on the planet.  We also gain a better understanding of the febrile creative atmosphere that percolated through the laboratories leading the way in translational medicine, and gain insight into the art, science, successes, failures and providence that underlie major scientific breakthroughs.  Anybody interested in the questions of where modern medicines come from, how health outcomes around the globe are affected by research and imagination, and where the future of drug discovery is leading, will be rewarded by exploring Cerami’s life in translation.  This book is not restricted to those with a professional interest in science, because anyone dedicated to living a life of creativity and discovery will be rewarded by reading this book.  In many respects, Cerami’s life reflects the modern metaphor of the ‘American dream’ with his journey from humble beginnings on a chicken farm in rural New Jersey, to occupying a place in  the highest echelons of the US scientific establishment.  His journey in translational medicine was propelled forward by two obsessions; the idea that he could help people who were sick, and the excitement of discovery. In following his two great passions, he trained a generation of specialists in translational medicine that continue to transform our understanding of, and treatments for, human disease.  Anthony Cerami’s work has shown how science has become an important force for social change by laying the foundations of modern translational medicine.
 

Distinguished expert in vaccine development John Rhodes tells the story of the first approved COVID-19 vaccines and offers an essential, up-to-the-minute primer on how scientists discover, test, and distribute vaccines.

As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been—when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time.  In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment—and will lead to multiple COVID-19 vaccines.

Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won’t be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans.

As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.
 

Explores the course of development of German seroanthropology from its origins in World War I until the end of the Third Reich. Gives an all encompassing interpretation of how the discovery of blood groups in around 1900 galvanised not only old mythologies of blood and origin but also new developments in anthropology and eugenics in the 1920s and 1930s. Boaz portrays how the personal motivations of blood scientists influenced their professional research, ultimately demonstrating how conceptually indeterminate and politically volatile the science of race was under the Nazi regime.

 In Lousy Sex Gerald Callahan explores the science of self, illustrating the immune system’s role in forming individual identity. Blending the scientific essay with deeply personal narratives, these poignant and enlightening stories use microbiology and immunology to explore a new way to answer the question, who am I?

“Utterly absorbing. Nearly every paragraph brings a revelation.”—Bill Bryson • “Wise, and beautifully written. . . . It will change the way you think about your body and live your life.”—Chris van Tulleken • “This great book from a world expert offers practical tips and dispels many myths.”—Tim Spector

A world-renowned scientist offers a much-needed analysis of what it takes to have good immune health—helping readers navigate what can really help, what is a complete myth, and why.

Does orange juice help ward off colds? And how does our age affect our ability to recover from one? When it comes to immunity, are we really what we eat? Or how much we eat? We are surrounded by big questions and big claims about enhancing our immune systems, so how do we tell the fiction from the facts? And, ultimately, what can we do to reduce our chances of getting sick?
 
World-leading immunologist Daniel M. Davis offers answers in this authoritative, highly accessible, myth-busting guide to the effects of stress, age, exercise, weight, nutrition, sleep, vaccines, and mental health on our immune health. Taking us to the cutting edge of immunology research and explaining both what we know and how we know it, Self-Defense helps readers spot phony claims and make informed choices. Davis shows us that everyone’s immune system is entirely unique, and that’s why we should be wary of one-size-fits-all “cures.” We learn how exercise, for example, has all sorts of different, even opposing, short- and long-term effects on our immune health. And while our gut microbes are vitally important, it’s unlikely that yogurt drinks can really boost your immune system to stop you getting ill.
 
An eye-opening window into some of the astonishing possibilities for the future, when it comes to distinguishing bogus and beneficial health claims about everything from vitamin D to inflammation and cancer therapies, Davis’s book may be your best self-defense.