Dr. Kaplan, winner of $100,000 Kettering Prize for cancer research, has now updated and enlarged his authoritative reference, once again drawing heavily upon the uniquely comprehensive and coherent Stanford data garnered over a twenty-year period. This edition incorporates discussion of the newer radionuclides, computed tomography and ultrasound, as well as such recent developments as the transmissibility controversy.

Major sections have been added on cell culture, surface marker characterization, and cytogenetics. The material on cell-mediated immunity has been doubled, and an entirely new chapter has been included on chemotherapy, offering an analysis of evidence bearing on the selection of optimal treatment.