Condensed Table of Contents
Analytical Table of Contents
Introduction
Part I. An Introduction to the Human Experimentation Process
Chapter One. The Jewish Chronic Disease Hospital Case
A. How and by Whom Should Research Policy Be Formulated?
B. How and by Whom Should the Research Process Be Administered?
C. How and by Whom Should the Consequences of Research Be Reviewed?
Chapter Two. The Wichita Jury Recording Case
A. How and by Whom Should Research Policy Be Formulated?
B. How and by Whom Should the Research Process Be Administered?
C. How and by Whom Should the Consequences of Research Be Reviewed?
Chapter Three. The Impact of Societal Dynamics on Human Experimentation
A. Man's Quest for Knowledge and Mastery
B. Man's Willingness to Risk Human Lives
C. Man's Readiness to Delegate Authority to Experts
Chapter Four. Perspectives on Decisionmaking
A. Planning by Individuals - The Market System
B. Collective Planning - The Rational-Comprehensive Approach
C. Collective Planning - The Step-by-Step Approach
Part II. The Authority of the Investigator as Guardian of Science, Subject and Society
Chapter 5. Experimentation without Restriction
A. Prologue - Experiments Prior to 1939
B. United States v. Karl Brandt
C. Epilogue - Experiments Subsequent to 1945
Chapter Six. What Consequences to Subjects Should Affect the Authority of the Investigator
1. Interferences with Self-Determination and Privacy
2. Interferences with Psychological Integrity
3. Interferences with Physical Integrity
1. Choice of and Attitude toward Subjects?
2. Awareness of Participation?
3. Disclosure of Risks?
4. Disclosure of Manipulation?
5. Benefits to Subjects?
6. Pursuit of Knowledge?
7. Values of Investigator?
8. Limits of Prediction?
9. Interests of Profession?
10. Interests of Society?
Chapter Seven. What Consequences to Society Should Affect the Authority of the Investigator?
1. Interferences with Human Behavior?
2. Interferences with Human Evolution
3. Interferences with Mores and Laws
1. Choice of and Attitude toward Subjects?
2. Benefits to Individuals?
3. Pursuit of Knowledge?
4. Values of Investigator?
5. Interests of Science?
6. Interests of Society?
7. Limits of Prediction?
Part III. The Authority of the Subject as Guardian of His Own Fate
Chapter Eight. What Are the Functions of Informed Consent?
A. An Historical Perspective
B. To Promote Individual Autonomy
C. To Encourage Rational Decisionmaking
D. To Protect the Experimental Process
E. To Increase Society's Awareness
Chapter Nine. What Limitations Are Inherent in Informed Consent?
A. Barriers to Achieving Autonomy
B. Barriers to Rational Decisionmaking
C. Barriers to Comprehension
Chapter Ten. What Limitations Should Be Imposed on Informed Consent?
A. In the Subject's Interests?
B. in Society's Interests?
Part IV. The Authority of Professional and Public Institutions
Chapter Eleven. Experimentation with Volunteers and Patient-Subjects
A. Balancing the Interests of Science, Society and the Individual
B. Medical Innovation and the State - A Case Study of Oral Contraception
C. Medical Innovation and the Profession - A Case Study of Mitral Valve Surgery
D. Appraising the Role of the Participants
1. In Formulating Policy
2. In Administering Research
3. In Reviewing Decisions and Consequences
Chapter Twelve. Experimentation with Uncomprehending Subjects
A. Case Studies of Children
B. Appraising the Role of the Participants
Chapter Thirteen. Experimentation with Captive Subjects
A. Case Studies of Prisoners and Soldiers
B. Appraising the Role of the Participants
Chapter Fourteen. Experimentation with Dying Subjects
A. Case Studies of the Dying
B. Appraising the Role of the Participants
Table of Cases
Table of Authors
Table of Books and Articles
Subject Index