Beyond the Lab and the Field analyzes infrastructures as intense sites of knowledge production in the Americas, Europe, and Asia since the late nineteenth century. Moving beyond classical places known for yielding scientific knowledge, chapters in this volume explore how the construction and maintenance of canals, highways, dams, irrigation schemes, the oil industry, and logistic networks intersected with the creation of know-how and expertise. Referred to by the authors as “scientific bonanzas,” such intersections reveal opportunities for great wealth, but also distress and misfortune.

This volume explores how innovative technologies provided research opportunities for scientists and engineers, as they relied on expertise to operate, which resulted in enormous profits for some. But, like the history of any gold rush, the history of infrastructure also reveals how technologies of modernity transformed nature, disrupting communities and destroying the local environment. Focusing not on the victory march of science and technology but on ambivalent change, contributors consider the role of infrastructures for ecology, geology, archaeology, soil science, engineering, ethnography, heritage, and polar exploration. Together, they also examine largely overlooked perspectives on modernity: the reliance of infrastructure on knowledge, and infrastructures as places and occasions that inspired a greater understanding of the natural world and the technologically made environment.

From a journalist and former lab researcher, a penetrating investigation of the explosion in cases of scientific fraud and the factors behind it.

In the 1970s, a scientific scandal about painted mice hit the headlines. A cancer researcher was found to have deliberately falsified his experiments by coloring transplanted mouse skin with ink. This widely publicized case of scientific misconduct marked the beginning of an epidemic of fraud that plagues the scientific community today.

From manipulated results and made-up data to retouched illustrations and plagiarism, cases of scientific fraud have skyrocketed in the past two decades, especially in the biomedical sciences. Fraud in the Lab examines cases of scientific misconduct around the world and asks why this behavior is so pervasive. Nicolas Chevassus-au-Louis points to large-scale trends that have led to an environment of heightened competition, extreme self-interest, and emphasis on short-term payoffs. Because of the move toward highly specialized research, fewer experts are qualified to verify experimental findings. And the pace of journal publishing has exacerbated the scientific rewards system—publish or perish holds sway more than ever. Even when instances of misconduct are discovered, researchers often face few consequences, and falsified data may continue to circulate after an article has been retracted.

Sharp and damning, this exposé details the circumstances that have allowed scientific standards to decline. Fraud in the Lab reveals the intense social pressures that lead to fraud, documents the lasting impact it has had on the scientific community, and highlights recent initiatives and proposals to reduce the extent of misconduct in the future.

Throughout his remarkable career, Donald Pfaff has demonstrated that by choosing problems and methods with care, biologists can study the molecular mechanisms of brains more complex than those of fruit flies, snails, roundworms, and other invertebrates. His half century in the lab, starting with his discovery of hormone receptors in the brains of mammals and leading to the first detailed account of a neural circuit for mammalian behavior, puts him in a unique position to survey the origins and development of behavioral neurobiology and the current state of research. How the Vertebrate Brain Regulates Behavior offers a close-up, conversational perspective on scientific struggles and successes throughout a fifty-year quest to understand how behavior is regulated in a complex organism.

In graduate school, when Pfaff expressed a desire to study behavioral regulation, his advisor suggested focusing on hormones. Pfaff’s investigation into the hormonal basis of female sexual behavior in laboratory rats led him to a comprehensive appreciation of how hormone-dependent neurons work through neural circuits to produce discrete behaviors among all vertebrates. This breakthrough, along with other researchers’ findings, established a link between molecular biology and neuroscience that opened up a fruitful new field of inquiry.

Pfaff’s approach is to focus on one solvable problem and explore it from many angles. He begins with a single observed behavior and traces its regulation through a series of biological mechanisms—from hormones to genes to neural circuits. Pfaff’s relentless pursuit of his goals continues to inspire neuroscientists today.

Never has the spirit of innovation been more highly valued than today. Around the world, people see the hard-to-teach skills of creativity as the lifeblood of cultural change and the engine of economic development. In The Lab, David Edwards presents a blueprint for revitalizing labs with "artscience"? creative thought that erases conventional boundaries between art and science?to produce innovations that otherwise might never see the light of day.At the heart of The Lab is "cultural incubation," whereby ideas translate with free-wheeling public exchange through a kind of innovation funnel—from educational settings (as in The Lab at Harvard University), to cultural settings (as at Le Laboratoire in Paris and elsewhere), to realizations as innovative products or humanitarian initiatives (within LaboGroup and other translation labs around the globe). With examples ranging from breathable chocolate (Le Whif) to contemporary art installations that explore the neuroscience of fear, Edwards shows how a measured-risk, seed-investment, mentorship-focused network of labs can allow exotic, unexpected ideas to flourish without being killed off at the first hint of impracticality.Unique to the innovation funnel is how creator risk is encouraged but also managed by mentors and others in each lab, so that the most daring ideas—lighting African villages with microbiotic lamps, or cleaning the air with plant-based filters—can emerge within passionate and sometimes inexperienced creative bands.Lively and engaging, replete with anecdotes that bring Edwards's unique personal experience in developing artscience labs to life, The Lab approaches innovation from exciting new angles, finding invigorating ways to repurpose our most creative assets—in scientific exploration, artistic imagination, and business model-building. David Edwards teaches at Harvard University in the School of Engineering and Applied Sciences. His creative work is described at www.davidideas.com.

Zeolites are natural or synthetic materials with porous chemical structures that are valuable due to their absorptive and catalytic qualities. Metal-Organic Frameworks (MOFs) are manmade organometallic polymers with similar porous structures. This introductory book, with contributions from top-class researchers from all around the world, examines these materials and explains the different synthetic routes available to prepare zeolites and MOFs. The book also highlights how the substances are similar yet different and how they are used by science and industry in situations ranging from fueling cars to producing drugs.