front cover of Hard Science, Hard Choices
Hard Science, Hard Choices
Facts, Ethics, and Policies Guiding Brain Science Today
Sandra Ackerman
Dana Press, 2006
Advances in neuroscience research are rapidly bringing new and complex issues to the forefront of medical and social ethics, and scholars from diverse fields have been coming together to debate the issues at stake. Acclaimed science writer Sandra Ackerman witnessed one such gathering, and here she skillfully synthesizes those proceedings into a concise presentation of the challenges that neuroscience and neuroethics currently face. 

Top scholars and scientists in neuroscience and ethics convened at the Library of Congress in Washington, D.C., in May 2005. They included Michael Gazzaniga, director of the Center for Cognitive Neuroscience at Dartmouth College; Marcus Raichle of the Washington University School of Medicine in St. Louis; Harvard University provost Steven Hyman; Judy Illes, cofounder of the Stanford Brain Research Center; University of Virginia bioethicist Jonathan Moreno; Stacey Tovino of the Health Law and Policy Institute at the University of Houston Law Center; and Stanford law professor Hank Greely.  

Ackerman weaves the invigorating arguments and discussions among these and other prominent scholars into a seamless and dynamic narrative. She reveals the wide array of issues that have emerged from recent research, including brain imaging, free will and personal responsibility, disease diagnosis and prediction, brain enhancement, and the potential social, political, and legal ramifications of new discoveries. Translating these complex arguments into an engrossing account of neuroethics, she offers a rare view of science—and ethics—in the making.
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Hemispheric Asymmetry
What's Right and What's Left
Joseph B. Hellige
Harvard University Press

Is "right-brain" thought essentially creative, and "left-brain" strictly logical? Joseph B. Hellige argues that this view is far too simplistic. Surveying extensive data in the field of cognitive science, he disentangles scientific facts from popular assumptions about the brain's two hemispheres.

In Hemispheric Asymmetry, Hellige explains that the "right brain" and "left brain" are actually components of a much larger cognitive system encompassing cortical and subcortical structures, all of which interact to produce unity of thought and action. He further explores questions of whether hemispheric asymmetry is unique to humans, and how it might have evolved. This book is a valuable overview of hemispheric asymmetry and its evolutionary precedents.

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How the Vertebrate Brain Regulates Behavior
Direct from the Lab
Donald Pfaff
Harvard University Press, 2017

Throughout his remarkable career, Donald Pfaff has demonstrated that by choosing problems and methods with care, biologists can study the molecular mechanisms of brains more complex than those of fruit flies, snails, roundworms, and other invertebrates. His half century in the lab, starting with his discovery of hormone receptors in the brains of mammals and leading to the first detailed account of a neural circuit for mammalian behavior, puts him in a unique position to survey the origins and development of behavioral neurobiology and the current state of research. How the Vertebrate Brain Regulates Behavior offers a close-up, conversational perspective on scientific struggles and successes throughout a fifty-year quest to understand how behavior is regulated in a complex organism.

In graduate school, when Pfaff expressed a desire to study behavioral regulation, his advisor suggested focusing on hormones. Pfaff’s investigation into the hormonal basis of female sexual behavior in laboratory rats led him to a comprehensive appreciation of how hormone-dependent neurons work through neural circuits to produce discrete behaviors among all vertebrates. This breakthrough, along with other researchers’ findings, established a link between molecular biology and neuroscience that opened up a fruitful new field of inquiry.

Pfaff’s approach is to focus on one solvable problem and explore it from many angles. He begins with a single observed behavior and traces its regulation through a series of biological mechanisms—from hormones to genes to neural circuits. Pfaff’s relentless pursuit of his goals continues to inspire neuroscientists today.

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How to Grow a Human
Adventures in How We Are Made and Who We Are
Philip Ball
University of Chicago Press, 2019
Two summers ago, scientists removed a tiny piece of flesh from Philip Ball’s arm and turned it into a rudimentary “mini-brain.” The skin cells, removed from his body, did not die but were instead transformed into nerve cells that independently arranged themselves into a dense network and communicated with each other, exchanging the raw signals of thought. This was life—but whose? 

In his most mind-bending book yet, Ball makes that disconcerting question the focus of a tour through what scientists can now do in cell biology and tissue culture. He shows how these technologies could lead to tailor-made replacement organs for when ours fail, to new medical advances for repairing damage and assisting conception, and to new ways of “growing a human.” For example, it might prove possible to turn skin cells not into neurons but into eggs and sperm, or even to turn oneself into the constituent cells of embryos. Such methods would also create new options for gene editing, with all the attendant moral dilemmas. Ball argues that such advances can therefore never be about “just the science,” because they come already surrounded by a host of social narratives, preconceptions, and prejudices. But beyond even that, these developments raise questions about identity and self, birth and death, and force us to ask how mutable the human body really is—and what forms it might take in years to come. 
 
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front cover of Human Language and Our Reptilian Brain
Human Language and Our Reptilian Brain
The Subcortical Bases of Speech, Syntax, and Thought
Philip Lieberman
Harvard University Press, 2002

This book is an entry into the fierce current debate among psycholinguists, neuroscientists, and evolutionary theorists about the nature and origins of human language. A prominent neuroscientist here takes up the Darwinian case, using data seldom considered by psycholinguists and neurolinguists to argue that human language--though more sophisticated than all other forms of animal communication--is not a qualitatively different ability from all forms of animal communication, does not require a quantum evolutionary leap to explain it, and is not unified in a single "language instinct."

Using clinical evidence from speech-impaired patients, functional neuroimaging, and evolutionary biology to make his case, Philip Lieberman contends that human language is not a single separate module but a functional neurological system made up of many separate abilities. Language remains as it began, Lieberman argues: a device for coping with the world. But in a blow to human narcissism, he makes the case that this most remarkable human ability is a by-product of our remote reptilian ancestors' abilities to dodge hazards, seize opportunities, and live to see another day.

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